Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"Myonuclei"”.
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The isolation of syaptic myonuclei and Schwann cell nuclei for DNA analysis from human skeletal muscle
… alterations in gene expression of synaptic myonuclei and terminal Schwann cells and the development of a highly-regulated synaptic structure. To understand neuromuscular junction abnormalities associated with cerebral palsy, a method for assessing the regulation of gene expression in …
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Novel applications of flow cytometry to assess whole murine skeletal muscle and myonuclei number responses to atrophy and recovery.
This thesis will present an introduction to cellular and molecular adaptation to loading and unloading of skeletal muscle, whilst exploring the advantages and disadvantages of current techniques employed in the field of exercise biochemistry. In response to the current techniques used to assess the …
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EFFECTS OF EXERCISE PRECONDITIONING ON MUSCLE HYPERTROPHY AND MITOCHONDRIAL REMODELING FOLLOWING THE SUBSEQUENT RESISTANCE TRAINING
… investigated the effect of increased number of myonuclei in response to the previous resistance exercise preconditioning on mitochondrial adaptations to subsequent resistance training. Our central hypothesis was that pre-trained muscles would show an accelerated acquisition of training-induced …
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Skeletal muscle adaptations in cachectic, tumor-bearing rats
… tumor-bearing rats had ~1.5 fold increase in myonuclei/fiber ratios compared those of sham-operated, tumor-bearing controls (n = 6). Therefore, cancer cachexia did not prevent myonuclear accretion necessary for skeletal muscle hypertrophy. Little data exists on adaptations to myosin heavy …
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Pax3 expression in satellite cells of avian skeletal muscle spindles during normal development and with experimental muscle overload
… mature muscles. SCs are activated to form new myonuclei during muscle hypertrophy, regeneration and repair. Intrafusal fibers of muscle spindles are thought to persist in a comparatively immature state as, unlike extrafusal fibers, they maintain small diameters, developmental myosins, Myf5 …
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Expression and Putative Functions of Fibroblast Growth Factor 10 (Fgf10) in Developing and Adult Skeletal Muscles
… showed that a subpopulation of Fgf10-expressing myonuclei expresses this satellite stem cell marker. To delineate the function of Fgf10, I examined the limbs of newborn Pax3- Cre::Fgf10(flox/-) double transgenic mice, and I discovered that myofiber growth was impaired in Fgf10-expressing muscles. …
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Perivascular cell contribution to skeletal muscle repair following physiological injury
… cells), and repair (fiber CSA, CLN+ fibers, myonuclei content). To determine the impact of the pericyte secretome on myoblast expansion and myotube development, CD146+Lin- pericytes were isolated from adult male wild type mouse skeletal muscle via enzymatic digestion and FACS. Following 12 …
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Motor neurone and muscle nuclear changes in development and disease
… pattern of anterior horn cell nuclei and myonuclei, they did provide normal values for comparison with data obtained from diseased neural and muscle tissue. The finding that in Duchenne muscular dystrophy (from tissue culture, fetuses at risk and juvenile biopsies) the muscle nuclei are …
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Cardiac Calsequestrin Phosphorylation And Trafficking In The Mammalian Cardiomyocyte
… all visualized and found to encapsulate both myonuclei. Additionally, time course studies of CSQ-DsRed, in conjunction with anti-DsRed immunostaining, highlighted a perinuclear rough ER site of biosynthesis for CSQ2. The fusion protein exhibited a tetramerization-dependent trafficking …
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The molecular memory of exercise in skeletal muscle
… RETRAINing elicits a shift toward more oxidative myonuclei, the most striking finding is the supportive role of fibro-adipogenic progenitors (FAPs) and stromal cells in mediating the cellular memory of exercise. This finding challenges the typical myonucleus-centric view of the memory of exercise …
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The molecular memory of exercise in skeletal muscle
… RETRAINing elicits a shift toward more oxidative myonuclei, the most striking finding is the supportive role of fibro-adipogenic progenitors (FAPs) and stromal cells in mediating the cellular memory of exercise. This finding challenges the typical myonucleus-centric view of the memory of exercise …
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Optimizing Recovery: the impact of essential amino acid supplementation and blood flow restriction training on skeletal muscle inflammatory response post-eccentric damage
Skeletal muscle is a highly adaptable tissue. Whether recovering from an invasive surgery or a difficult workout, healthy muscle cells rapidly respond to physiological demands through cellular repair, remodeling, and growth. Prolonged disuse, often necessitated by injury or post-operative recovery, …