Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 24 for “"Myometrial"”.
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The effects of diethylstilbestrol on myometrial contractility in mice
… was no significant difference for the total myometrial thickness or any of the variables testing uterine contractility in mice. Further studies at the muscular and cellular levels, along with testing of other estrogenic compounds, would be of value to this area of research"--Document.</p>
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Effect of Long-term Hypoxia on Myometrial Contractility in the Pregnant Sheep
… research from our laboratory has shown that myometrial contractility is reduced in pregnant sheep exposed to long-term hypoxia (LTH). The studies in this dissertation examined the effect of LTH on various aspects of Ca<sup>2</sup> regulation, large-conductance, Ca<sup>2+ </sup>activated (BK) …
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Observations of idazoxan and xylazine on the myometrial response of the normal, cycling virgin rat in vitro
The aim of this study was to determine the contractile responses of normal virgin rat uterine smooth muscle to the ⍺₂ adrenergic agonist, xylazine HCl, in the presence or absence of the selective ⍺₂ adrenoceptor blocker, idazoxan HCl. Sections of full thickness uterus measuring 5 x 1 x 1 mm taken …
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Characterization of the NADPH oxidase complex in human leiomyoma and normal myometrial smooth muscle cells and its role in PDGF and EGF signaling pathways
… EGF and PDGF pathways in leiomyoma and normal myometrial SMCs. The main findings of this work were: 1) leiomyoma smooth muscle cells (LSMCs) and myometrial smooth muscle cells (MSMCs) produce ROS in response to EGF and PDGF; 2) ROS are necessary for EGF- and PDGF-induced LSMCs and MSMCs …
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Role of MicroRNA-29 and ADAM12 in the Regulation of REST Dependent Signaling Pathways in Uterine Fibroids
… analysis, we found silencing REST in primary myometrial SMCs led to an increase in a number of downstream target genes, a profile similar to what is seen in fibroid tumor samples. Furthermore, Ingenuity® pathway analyses of gene expression datasets for fibroids indicate that the loss of REST …
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Gene Expression in Endometrial Tissues of Normal Mares and Mares With Delayed Uterine Clearance
… a cranioventrally tilted uterus, defective myometrial contractions, decreased intrauterine immune activity, inappropriate lymphatic drainage or mucus overproduction. The objective of this research was to evaluate gene expression of selected genes in endometrial tissue samples taken from …
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Antagonistic Roles of miR-199a-3p/miR-214 and the miR-200 Family in the Regulation of Uterine Contractility During Pregnancy and Labor
… play critical and opposing roles in regulating myometrial quiescence and contractility during pregnancy and labor (Kamel et al., 2010). While these contrasting hormonal effects are likely mediated via differential regulation of inflammatory and contractile genes, the underlying mechanisms remain …
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Characterization of NADPH Oxidases in Uterine Smooth Muscle during Pregnancy
… prepare the tissue for parturition. Using rat myometrial tissue collected from pregnant rats throughout gestation, an immortalized human myometrial cell line, as well as immunoblot and immunofluorescence analyses, the spatial and/or temporal expression pattern of Nox1, Nox4, as well as their …
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The Role of PRICKLE1 in the Regulation of Uterine Structure and Physiology
… and pregnancy. The smooth muscle cells of the myometrial layer are organized into several sub-layers with longitudinal and circular orientations and help to facilitate uterine contractions and sperm transport. The specific cellular arrangement and orienertaion is crucial for the layer’s …
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Determining the endometrial phenotype of women with abnormal uterine bleeding
… in the endometrium due to the presence of these myometrial conditions. Fibroids and adenomyosis are sex-steroid dependant conditions, and lines of evidence suggest there is an impaired progesterone response in the endometrium from women with adenomyosis, however, there is a dearth of evidence …
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Phosphorylation of the Estrogen Receptor Alpha (ERα) at Serine 118 by Phospho-p44/42 MAPK and Regulation by Estrogen and Progesterone in Human Uterine Leiomyoma Tissue and Cells
… nuclear antigen (PCNA) in human leiomyoma and myometrial tissues during the proliferative and secretory phases of the menstrual cycle. <em>In vitro</em> studies to assess proliferation of uterine leiomyoma (UtLM) and uterine smooth muscle (UtSMC) cells and expression of ERα-phospho-Ser118 and …
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Uterine Remodeling During Pregnancy - Studies on the Effect of Heparin/Heparan Sulfate
… cervical softening combined with effective myometrial contractions. This is accomplished by an extensive remodeling of the extracellular matrix in both the cervix and the uterus, executed by different types of cells and mediators in a complex interplay. The overall purpose of this project …
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Post-Transcriptional Regulation by microRNAS in Pregnancy and Parturition
… blocked oxytocin-induced contractility in human myometrial cells. Together, these findings implicate the miR-200 family and their targets ZEB1 and ZEB2 as novel P4/PR-mediated regulators of uterine quiescence and contractility during pregnancy and labor, and shed new light on the molecular …
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Intimations on the Development of Effective Treatment for the Prevention of Preterm Birth: β3 Adrenergic Receptor Signaling in the Human Myometrium
… are revealed to be increased production of NO in myometrial endothelial cells, stimulation of Ca2+ activated K+ channel (BKCa), and down regulation of the contractile associated protein connexin 43 (Cx43). The mechanosensitive channel Piezo1 was identified in the myometrium and showed to promote …
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The effects of environmentally relevant toxicants on female reproduction and embryo development
… was evaluated by measuring the thickness of the myometrial layers (inner and outer), luminal epithelium height, counting the number of glands and finding the percentage of proliferating cells within the uterus. The results from this study demonstrated that exposure to DEHP decreased cellular …
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Modeling And Detection Of Uterine Contractions Using Magnetomyography
… during pregnancy. Existing models of myometrial contractions approach the problem either at an organ level or lately at a cellular level. At the organ level, the models focus on generating contractile forces that closely resemble clinical measurements of normal intrauterine pressure …
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Biospectroscopy towards screening and diagnosis of cancer
… for histopathological diagnosis. The endometrial-myometrial junction areas of benign uterine tissues were scrutinised by Synchrotron FTIR and FPA. These techniques in combination with multivariate analysis revealed clear segregation between the functionalis and basalis layers within the uterine …
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Role of kinins in mediating vascular function in healthy pregnancy and pre-eclampsia
… B2 and B1 receptor agonists and antagonists on myometrial vascular tone were tested on arteries from healthy pregnancy and pre-eclampsia. The results demonstrated that in addition to classical bradykinin B2 receptor-mediated relaxation, a subset of healthy patients exhibited nitric …
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Die Expression der G-Protein gekoppelten Rezeptoren LGR 4, LGR 5, LGR 7 und LGR 8 im humanen nicht-graviden und graviden Uterus sowie in Karzinomzelllinien des Reproduktionstraktes und der Mamma
… 8 system is involved in the endometrial-myometrial dialogue. The chorioncarcinoma cell lines Jeg-3 and Jar as well as the endometrial carcinoma cell line Hec 1a express the LGR 4-, LGR 5- and LGR 7-mRNA, whereas BeWo-cells additionally express the LGR 7-mRNA. In the breast carcinoma cell …
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