Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 36 for “"Myogenin"”.
-
Myogenin Modulates Exercise Endurance By Altering Skeletal Muscle Metabolism
… The requirement of one of these MRFs, myogenin (Myog), during embryonic muscle development suggests an equally important role in adult muscle. In this study, we have determined the function of myogenin during adult life using a conditional allele of Myog. In contrast to embryonic …
-
Elucidating Functional Roles For Myogenin In Adult Skeletal Muscle Metabolism, Exercise Capacity, and Regeneration
… helix-loop-helix myogenic transcription factors, myogenin, Myf5, MRF4, and MyoD are critical for embryonic skeletal muscle development. Myogenin is necessary for the terminal differentiation of myoblasts into myofibers during embryogenesis, but little is known about the roles played by myogenin in …
-
ΕΠΙΔΡΑΣΗ ΤΗΣ ΜΗΧΑΝΙΚΗΣ ΦΟΡΤΙΣΗΣ ΣΕ ΦΥΣΙΟΛΟΓΙΚΟΥΣ ΚΑΙ ΓΗΡΑΣΜΕΝΟΥΣ ΣΚΕΛΕΤΙΚΟΥΣ ΜΥΟΒΛΑΣΤΕΣ
… C2C12. Μελετήθηκαν τα γονίδια MyoD, Myf5 και Myogenin ως δείκτες μυογένεσης, το Myostatin ως αρνητικός ρυθμιστής μυϊκής ανάπτυξης και ο παράγοντας Klotho, που έχει συνδεθεί με αντιγηραντικές ιδιότητες. Τα κύτταρα καλλιεργήθηκαν σε Passage 14 (φυσιολογικός φαινότυπος) και Passage 36 (γηρασμένος …
-
Analysis of the role of extracellular signal regulated kinase (ERK5) in the differentiation of muscle cells
… basic-helix-loop-helix proteins such as MyoD or myogenin bind. Moreover, myogenic differentiation is completely blocked, when ERK5 expression is inhibited by antisense RNA. The effect can be detected also on the expression level of myogenic determination and differentiation markers such as p21, …
-
Tissue Engineering von Skelettmuskelgewebe : neue Ansätze zur Generierung von Skelettmuskelgewebe in vitro und in vivo
… und die beiden Transkriptionsfaktoren MyoD und Myogenin bestätigten die stattfindende Myogenese. Die mittels RT-PCR und Western-Blot-Analyse untersuchte Expression von neuronalem Agrin, der Triadin-Isoform Trisk51 und der epsilon-Untereinheit des reifen Azetylcholinrezeptors belegten die …
-
Unraveling the molecular mechanisms of the class II transactivator, CIITA in skeletal muscle
… by CIITA, which specifically interacts with myogenin. CIITA acts by both, repressing the expression and inhibiting the activity of myogenin at different stages of myogenesis. The IFN-gamma mediated repression is reversible, with myogenesis proceeding normally upon removal of IFN-gamma. We …
-
Behaviour of human myoblasts in vitro: role of ageing and inflammatory cytokines
… and markers of differentiating muscle cells were myogenin and myosin heavy chain. Additional parameters observed were DNA damage and analysis of specific cytokines in the cell secretome. No differences in any parameter measured were found between cells of young and old people. However senescent …
-
Tissue Engineering von Skelettmuskulatur : Vergleich eines in vitro und in vivo Ansatzes
… Transkriptionsfaktoren der Myogenese MyoD und Myogenin als auch die Expression der Epsilon-Untereinheit des adulten Azetylcholinrezeptors. <br>Zunächst wurde die Genexpression der Muskelvorläuferzellen in 2D-Zellkultur und 3D-Fibrinkultur untersucht und verglichen, dabei konnte festgestellt …
-
Role of the Sh3 and Cysteine-Rich Domain 3 (STAC3) Gene in Proliferation and Differentiation of Bovine Satellite Cells
… cells by quantifying the expression levels of myogenin and myosin heavy chain genes, and by quantifying fusion index. STAC3 knockdown stimulated mRNA and protein expression of myogenin, and myosin heavy chain 3 and 7, and increased fusion index of bovine satellite cells. These data together …
-
Transcriptional Regulation of Neurogenic Atrophy-Induced Gene Expression by Muscle Ring Finger-1 and Myogenic Regulatory Factors
… myogenic regulatory factors (MRFs), MyoD1 and myogenin, caused significant activation of the MuRF1 and MAFbx reporter constructs. However, co-overexpression of MuRF1 with MyoD1 or myogenin resulted in reversal of MRF induction of reporter gene activity, and synergistic repression of a …
-
The Change in the Concentration Levels of Extracellular Vesicles and of Cytokines in the circulatory blood system in Response to different exercise protocols
… of muscle cells the expression level of Myogenin in EV-treated C2C12 cells by plasma samples was determined by qPCR. The experimental conditions and cell model for the differentiation of C2C12 was standardised and the expression of muscle differentiation gene markers was analysed by …
-
Cytokine-Induced Igf-I Resistance in Progenitor Muscle Cells
… expression of myogenic transcription factors, myogenin and MyoD. Furthermore we show that JNK is a key downstream intermediate by which TNFalpha and ceramide inhibit the IGF-I myogenic activity. TNFalpha, C2-ceramide and N-SMase potently induce JNK enzymatic activity. Active JNK associates with …
-
Regulation of human satellite cells in vitro via inflammatory cytokines and myogenic transcription factors across proliferation and differentiation
… Additionally, mRNA levels of Pax7, MyoD, myogenin, IL-6, TNF-α, and TGF-β were assessed in satellite cells cultured from a subset of two endurance trained and two sedentary individuals from the larger group of 12 human subjects. The novelty of our study is the large number of human …
-
Genomic characterization of Six1 function during skeletal muscle differentiation
… muscle development, and comprise MyoD, Myf5, Myogenin and Myf6. Based on previous bioinformatics predictions, it was proposed that Six1 had a genome-wide function and cooperated with MRFs by co-regulating gene expression. A functional genomics approach (ChIP-on-Chip) was used to identify …
-
Construction of comparative and framework linkage maps for the identification of quantitative trait loci in cattle
… 1 (FUCA 1), interleukin 10 (1L10), myogenin (MYOG), phoshogluconate dehydrogenase (PGD), and the $\beta$ subunit of thyroid stimulating hormone (TSHB). The identified polymorphisms were used to map the loci using the paternal half-sib families of the Illinois Reference/Resource …
-
TBX2 IS INVOLVED IN MYOGENESIS AND ITS DEREGULATION PROMOTES TUMORIGENESIS IN RHABDOMYOSARCOMA
… we showed that TBX2 forms complex with myogenin and MyoD, and then recruits HDAC1 to muscle-specific promoters to repress the myogenin and MyoD dependent differentiation of myoblasts. In rhabdomyosarcoma (RMS), which is typically referred to as a muscle derived cancer, we found TBX2 was …
-
Growth response to resistance exercise : influence of exercise device
… RE increased (P < 0.05) mRNA expression of Myogenin (3.6 vs. 3.6 fold), and MyoD (2.2 vs. 2.0 fold) and decreased (P < 0.05) expression of Myostatin (1.4 vs. 1.5 fold) to a similar degree on both exercise devices. There was no change in the expression of Atrogin-1, MuRF-1 or MRF4 following …
-
Optimizing Ex Vivo Culture of Satellite Cells
… of myogenic commitment factors, MyoD and Myogenin. SR1 also succeeded to block myoblast differentiation into myotubes. SR1 treated established myoblast cells succeeded to repopulate satellite cell pool of recipient muscles. SR1 is described to work through an action on AHR (aryl …
-
The TAZ Protein Interactome in Striated Muscle
… and TLE3 repressed MyoD-driven activation of the myogenin promoter. Overall, these data demonstrate a role for a TAZ/TLE3 complex in repressing the myogenic differentiation machinery having implications for muscle development and regeneration.
Page 1 of 2