Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"Myogenic Regulatory Factors"”.
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Transcriptional Regulation of Neurogenic Atrophy-Induced Gene Expression by Muscle Ring Finger-1 and Myogenic Regulatory Factors
… MuRF1. Furthermore, ectopic expression of the myogenic regulatory factors (MRFs), MyoD1 and myogenin, caused significant activation of the MuRF1 and MAFbx reporter constructs. However, co-overexpression of MuRF1 with MyoD1 or myogenin resulted in reversal of MRF induction of reporter gene …
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Genomic characterization of Six1 function during skeletal muscle differentiation
The Six family of transcription factors counts six members in vertebrates (from Six1 to Six6). Six1 is important for skeletal muscle development: Six1-/- mouse neonates die at birth because of severe muscle hypoplasia. However, the molecular targets of Six1 are poorly characterized systematically. …
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Myogenin Modulates Exercise Endurance By Altering Skeletal Muscle Metabolism
The function of myogenic regulatory factors (MRFs) during adult life is not well understood. The requirement of one of these MRFs, myogenin (Myog), during embryonic muscle development suggests an equally important role in adult muscle. In this study, we have determined the function of myogenin …
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Optimizing Ex Vivo Culture of Satellite Cells
… in vitro behavior of satellite cells and to find factors that can control their differentiation pathways. I showed the effect of in vitro culture on transcription of various myogenic regulatory factors. I also showed the effect of various inhibitors on these factors. I found that treatment of …
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Role of JAK3 in Myogenic Differentiation
… differentiation is regulated by transcription factors, including members of the myogenic regulatory factors (MRFs) family and many signaling pathways. The JAK1 and JAK2 pathways are known to each have different effects on myoblast proliferation and differentiation; however, the role of JAK3 in …
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Investigating the role of Klhl31 in striated muscle
… delayed compared to the expression of early myogenic regulatory factors. With this study we wanted to analyse the function of Klhl31 during myogenesis in more detail. Using C2C12 mouse myotubes as our model cell line to study myogenic differentiation and myofibrillogenesis, we found that …
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The transcriptional regulation of skeletal muscle progenitor cell fate
… by a highly complex network of transcription factors whose expression is regulated by several families of molecules. However, not much is known about the early events that lead to the expression of muscle progenitor markers. This series of studies aims to further understand the mechanisms …
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Functional Genomics Characterization of Six4 During Skeletal Myogenesis
… of satellite cells, a quiescent population of myogenic progenitor cells characterized by expressing the transcription factor Pax7. Once activated, satellite cells repair the muscle damage and replenish the stem cell niche due to the coordinated function of several transcription factors …
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Multifunctional Regulators of Cardiac Disease and Development
Embryogenesis requires delicate regulatory mechanisms. A single cell embryo divides into millions of daughter cells to form an organism comprised of various organs with different shapes and function. Organogenesis is mainly controlled by genes that are expressed in a tissue-specific manner. Thus, …
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Postnatal Maturation Modulates Cerebrovascular Myogenic Tone
… stores to develop and maintain pressure-evoked myogenic tone in rat cerebral blood vessels. To test this hypothesis, pressure-induced myogenic tone and changes in artery wall ([Ca2+]i) were measured simultaneously in isolated endothelium denuded, fura-2 loaded middle cerebral arteries (MCA) from …