Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 29 for “"Myogenic Differentiation"”.
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Role of JAK3 in Myogenic Differentiation
Skeletal muscle differentiation is regulated by transcription factors, including members of the myogenic regulatory factors (MRFs) family and many signaling pathways. The JAK1 and JAK2 pathways are known to each have different effects on myoblast proliferation and differentiation; however, the role …
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Controlled Myogenic Differentiation of Mammalian Cell Lines by Temperature-Inducible Systems
… demonstrate efficient induction of exogenous pro-myogenic factors with a 2-hour heat shock at 43°C. In the presence of exogenous HSF1, we observed a rapid initiation of the myogenic differentiation process and a significant acceleration in the expression of late myogenic markers (myogenin and …
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The role of PAX3/PAX7-FKHR in mesenchymal stem cell myogenic differentiation and rhabdomyosarcomagenesis
… fusion protein, which is proposed to perturb the differentiation of muscle progenitor cells. Since PAX3/7-FKHR fusions result in rearrangements of PAX3/7 and FKHR genes, such that the PAX C-terminal domain is replaced by the potent FKHR transactivation domain, we sought to investigate the …
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Evaluation of Myogenic Differentiation Potential of BMD iPSCs in vitro and the Effect of Ubiquitination Inhibitors on Dystrophin Stability in vivo
… as the model system. The hypothesis is that myogenic differentiation of the BMD iPSC-derived myogenic progenitors and dystrophin expression and stability can be improved in vivo after the treatment with polyubiquitination inhibitors. Methods: The in vitro studies include evaluation of …
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The Cellular and Molecular Mechanisms of Prostaglandin E₂ in Myogenesis
… project is concerned with the role of PGE₂ in myogenic differentiation. Activation of PGE₂ signaling promoted C2C12 myogenic differentiation, which resulted from the upregulation of genes related to myogenic differentiation, calcium signaling and other pathways. Two EP receptors, EP1 and EP4, …
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APPLICATION OF POLYETHYLENE-GLYCOL LINKED MULTI-WALLED CARBON NANOTUBES FOR IMPROVED STEM CELL DIFFERENTIATION
… (PEG-CNT) FILMS ALONE COULD DIRECT THE SKELETAL MYOGENIC DIFFERENTIATION OF HUMAN MESENCHYMAL STEM CELLS (HMSCS), EVEN IN THE ABSENCE OF MYOGENIC INDUCTION FACTORS. TO ENHANCE THE MYOGENIC DIFFERENTIATION OF HMSCS, WE DESIGNED AND FABRICATED A PEG-CNTS COATED POLY-ACRYLAMIDE HYDROGEL WITH CLOSE …
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The TAZ Protein Interactome in Striated Muscle
… is a prominent regulator of cell proliferation, differentiation, and death. Previously, we characterized the Hippo transcriptional effector TAZ as a repressor of the myogenic differentiation program. Without DNA-binding ability, TAZ function exclusively depends on its protein:protein interaction …
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Cellular and molecular regulation of skeletal muscle regeneration
… found that Bex1 was temporarily expressed in myogenic cells with a nuclear-cytoplasmic trafficking pattern during embryonic development and postnatal regeneration. The exclusive expression of Bex1 in differentiated myocytes suggests that Bex1 may play unknown roles in regulating myogenic …
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Developmental regulation of the alpha(7) integrin chain during myogenesis
… of $\alpha$7 transcripts increased upon myogenic differentiation, differential splicing of transcripts is also observed at that time. This differential splicing of $\alpha$7 transcripts results in three different mRNAs which encode $\alpha$7 chains with three different cytoplasmic …
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Analysis of the role of extracellular signal regulated kinase (ERK5) in the differentiation of muscle cells
… muscle a function of the cascade during muscle differentiation was examined. ERK5 becomes activated upon induction of differentiation in mouse myoblasts. The selective activation of the pathway results in promoter activation of differentiation-specific genes, such as the cdk-inhibitor p21 gene, …
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Molecular mechanisms of mammalian cell survival and differentiation
… underlying mammalian cell survival and differentiation. In particular, I investigated the regulation of mammalian target of rapamycin (mTOR), an evolutionarily conserved Ser/Thr kinase that integrates signals from nutrient availability, growth factors, differentiation inducers, and …
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Ruolo della PLCγ1 e della PKCε nel differenziamento miogenico
… transduction pathway for cell proliferation and differentiation. Studies on signalling through the insulin/IGF-1 receptors in muscle differentiation have revealed that PLCγ1 is involved during this process and that both mRNA and protein levels were increased during myogenesis. Based on increasing …
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The effects of maternal and postnatal infections with porcine reproductive and respiratory virus on muscle growth and development in piglets
… in positive growth factors was observed as myogenic differentiation 1 (P<0.01) and myogenin (P<0.01) increased while myostatin expression decreased (P=0.04) in P piglets compared with C piglets. These data suggest maternal PRRSV infection restricts in utero muscle fiber development. …
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Direct Reprogramming Of Fibroblasts Into Muscle Or Neural Lineages By Using Single Transcription Factor With Or Without Myod Transactivation Domain
… the mouse embryonic fibroblasts (MEFs) into myogenic or neurogenic lineages, respectively. In addition, we created fusion transcription factors (Pax3 or NeuroD1) with the potent MyoD transactivation domain (MDA) that could facilitate radical acceleration of reprogramming into the desired cell …
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Six1 Is Important for Myoblast Proliferation Through Direct Regulation of Ccnd1
… Six1 regulates the expression of MyoD, a key myogenic gene, in muscle stem cells. Furthermore, loss-of-function of this protein, mediated by RNA interference, has implicated Six1 as essential towards normal myogenic differentiation. However, beyond Six1 and its involvement towards myogenesis, …
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Matrix-mediated formation & innervation of skeletal myotubes
… pores will be investigated in Chapter 2. Myogenic differentiation will be decoupled from matrix stiffness in an aligned microchanneled matrix in Chapter 3. In Chapter 4, the role of matrix stiffness on neural organoid development and, its ability to innervate and control the actuation of …
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Ruolo della fosfolipasi C-β1 nel differenziamento miogenico: identificazione di nuovi target nucleari
… D3 is highly induced during skeletal myoblast differentiation. We have previously shown that PLC-β1 activates cyclin D3 promoter during the differentiation of myoblasts to myotubes, indicating that PLC-β1 is a crucial regulator of mouse cyclin D3 gene. Here we report that PLC-β1 catalytic …
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Regulation of skeletal myogenesis by the mTOR signaling network
… skeletal myogenesis, cells in somites commit to myogenic lineage and differentiate into myoblasts, which then fuse to form multinucleated myofibers. Post-natal growth, repair, and maintenance of skeletal muscle are dependent on muscle satellite cells, which in response to stimuli differentiate …
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Implementation of circFISH to quantify the expression and cellular localization of circNFIX in cerebral palsy
… has been observed to be a regulatory factor in myogenic differentiation, showing differential expression in various stages of myogenesis, and can be potentially characterized as a key player in myogenic alterations in CP. This led to the hypothesis that circNFIX might be a key regulator in CP …
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Investigating the role of Klhl31 in striated muscle
… delayed compared to the expression of early myogenic regulatory factors. With this study we wanted to analyse the function of Klhl31 during myogenesis in more detail. Using C2C12 mouse myotubes as our model cell line to study myogenic differentiation and myofibrillogenesis, we found that …
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