Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"Myofilament"”.
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Postnatal Maturation Modulates Cerebrovascular Myogenic Tone
… contractile reliance on calcium influx and myofilament Ca2+ sensitivity, and increases reliance on release of calcium from intracellular stores to develop and maintain pressure-evoked myogenic tone in rat cerebral blood vessels. To test this hypothesis, pressure-induced myogenic tone and …
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Cellular mechanism of contractile dysfunction in the diabetic heart
… similar in both control and diabetic myocyte. Myofilament sensitivity was studied by plotting the relationship between contraction and Ca 2+ in controland STZ-induced diabetic myocytes. The results show that myofilament sensitivity for Ca2+ is increased in the STZ-induced myocytes but is …
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Redox Regulation of Type Iα PKA in the Heart
… RIα disulfide translocated to membrane and myofilament in isolated WT hearts in response to oxidant. Dual-specificity AKAP (D-AKAP) 1, D-AKAP2, AKAP220 and α/β tubulin were not co-purified with WT or KI RIα after cAMP-affinity capture. LC-MS/MS showed that the PKA substrates, alpha-enolase …
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Significance of low-abundance transcripts detected in Caenorhabditis elegans muscle SAGE libraries
… the role of low-expressed muscle genes in myofilament structure. RNAi results show that 14/34 (41%) of the genes screened had mild defects in myofilament organization. The SAGE libraries identified 6388 low-expressed transcripts, this work suggests that at least 16% (1022 genes) of these …
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The effects of Tumour necrosis factor-alpha and Interleukin-1-beta on intracellular calcium handling and contractility in sheep ventricular myocytes
… effects on the ryanodine receptor (RyR) and myofilament sensitivity to calcium.Sheep ventricular myocytes were used for all experiments. All procedures used accord with the Animals (Scientific Procedures) Act, UK, 1986 and Directive 2010/63/EU of the European Parliament. Intracellular calcium …
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Investigation of the mechanisms underlying the effects of hyperglycaemia on cardiac structural and electrical remodelling
… included a decrease in EB size and expression of myofilament proteins, α-actinin and α- and β-myosin heavy chain and a disruption of the striated organization of the myofilaments. Hyperglycaemia increased the proportion of TUNEL-positive cells and the expression of the pro-apoptotic marker …
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Probing Tissue Microstructure Using Susceptibility Contrast Magnetic Resonance Imaging
… anisotropy α-helix peptide bonds in myofilament proteins are capable of producing bulk susceptibility anisotropy on a scale measurable by MRI, and are potentially the chief sources of the experimentally observed anisotropy.</p><p>The growing use of paramagnetic contrast agents in …
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Contractile Properties of Striated Muscle in Development and In Disease
… the activation rate and force production of the myofilament can be enhanced without slowing the relaxation through using 2-deoxy-ATP.
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k-Opioid Receptor Dependent Cardioprotection in the Rat
… leading to reduced ATP utilization by the <br />myofilaments.</p> <p> We tested this hypothesis by correlating post-ischemic contractile recovery and myofibrillar actomyosin Mg2+ATPase activity in isolated rat hearts. Pre-ischemic treatment with the k-opioid receptor agonist U50,488 (U50, 1 mM) …
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The role of extracellular matrix in modulation of myocyte Ca2+ signalling and contraction in the isolated rat heart
… isolated myocytes. EPAC activation increase the myofilament Ca2+ sensitivity when Ca2+ currents were lowered by reducing the [Ca2+] to 0.5 mM which was removed by CamKII inhibition. This work indicates that EPAC contributes to Ca2+ signalling in a CamKII-dependent fashion in the cardiac tissue …
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Myocardial force and intracellular Ca2+ in an animal model of hypertensive heart failure
… SHR trabeculae was not associated with reduced myofilament Ca2+ sensitivity, since, although peak [Ca2+]i continued to increase with increasing [Ca2+]o, peak stress reached a plateau. Investigation of the force-frequency response between 0.2 and 10 Hz showed that the mismatch in peak Ca2+ and …
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Cellular mechanism of contractile dysfunction in diabetes-induced cardiomyopathy
… that morphological defects in contractile myofilament and associated structures cannot explain contractile dysfunctions seen in ventricular myocytes from STZ-treated animals. In conclusion the amplitude of contraction in diabetic myocytes was more pronounced compared to age-matched control. …
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The Future is Now in Twisted Coil Polymer Actuators (TCPA)
<p>This thesis aimed to fabricate and test twisted coiled polymer actuators (TCPA) to understand the mechanical and thermal aspects of this artificial muscle fiber. The purpose of this thesis was to find a linear relationship using the LVDT sensor, fabricating TCPA fibers, and interpreting the …