Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 62 for “"Myofibroblasts"”.
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Regulation of Endothelial Nitric Oxide Synthase in Pulmonary Myofibroblasts
… lifespan is between three and six years. Myofibroblasts are collagen-secreting cells essential for wound healing, but also implicated in the fibroproliferation and extra cellular matrix deposition commonly seen in IPF. The nitric oxide (NO) signaling pathway is implicated in …
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Interactions of Cardiomyocytes and Myofibroblasts: An Experimental and Theoretical Model Study
… fibroblasts in the heart can convert to myofibroblasts, a larger and more contractile phenotype between a fibroblast and a smooth muscle cell. Myofibroblasts are essential to wound healing, but can change the compliance and functioning of heart tissue and can produce pathological …
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Role of extracellular environment in mechanical properties of human cardiac fibroblasts and myofibroblasts
… contractile forces of cardiac fibroblasts and myofibroblasts. Hence, this dissertation aimed to investigate the effects of extracellular stiffness on mechanical properties of cardiac fibroblasts and myofibroblasts using engineered in vitro microenvironments with tuneable physical properties. …
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Expression and Regulation of the Insulin-like Growth Factor Axis Components in Rat Liver Myofibroblasts
Hepatische Sternzellen (HSC) und Lebermyofibroblasten (LMF) sind maßgeblich an der Leberfibrogenese beteiligt. Untersuchungen der letzten Jahre weisen darauf hin, dass HSC - im Gegensatz zu LMF - parallel mit ihrer Aktivierung der spontanen Apoptose unterliegen. LMF sind daher von zentraler …
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Expression of myofibroblasts and identification of angiotensin receptors in capsular contracture disease around mammary implants
… were harvested. Tissue was dissociated into myofibroblasts using collagenase and cultured to determine growth patterns. Expressions of myofibroblasts and Ang-II receptors (AT1 and AT2) within breast capsule tissue were also investigated using immunohistochemistry. The results show that …
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Investigation into the role of HMGb1 in relation to myofibroblasts and cancer cells exposed to various conditions
… of the central core of most solid tumours. Myofibroblasts are stromal cells present in many such solid tumours including those of the colon, and they are known to be involved in all stages of tumour progression. HMGb1 is a nuclear protein that plays an important role in nucleosome …
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The effects of angiotensin-converting enzyme inhibitors as a pharmacological treatment for Dupuytren’s disease
… of ANGT II receptors 1 (AT1) and 2 (AT2) in myofibroblasts derived from primary tissue of 11 patients who had the disease. My hypothesis is that myofibroblasts will express angiotensin receptors and that these will primarily be of the AT1 receptor subtype. Initially, the tissues were excised …
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The recruitment of stromal cells to the site of tumor formation
Myofibroblasts are an alpha-smooth muscle actin ([alpha]-SMA)-expressing cell type found within human mammary carcinomas, but not in the normal mammary gland. Myofibroblasts can enhance tumor formation by promoting angiogenesis and invasion, and we therefore sought to better understand how …
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Regulation of Lung Mesenchymal Cells By Epithelial Wnt Ligands
… identified two subpopulations of neonatal lung myofibroblasts – ductal myofibroblasts that envelop alveolar ducts that persist into adulthood and alveolar myofibroblasts that undergo developmental apoptosis. Among lung mesenchymal subpopulations, we also found that myofibroblasts and pericytes …
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Stromal Fibroblasts Restrain The Rate of Colon Cancer Progression and Metastasis By Suppressing Regulatory T Cells and Colon Cancer Stem Cells
… ECM remodeling enzymes, and other metabolites. Myofibroblasts are a distinct subtype of fibroblasts characterized by expression α-smooth muscle actin (αSMA). These cells are a dominant component of the microenvironment, and a FSP1 and FAP could be a different clone of fibroblasts. Myofibroblasts …
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The role of nerve growth factor and p75 neurotrophin receptor in recovery from liver fibrosis
Rodent hepatic myofibroblasts are susceptible to nerve growth factor-mediated apoptosis through p75 neurotrophin receptor ligation. Hepatic myofibroblast apoptosis is critical to resolution of liver fibrosis. I show that human hepatic myofibroblasts exhibit differential responses to mature and …
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Biomolecules that impact phenotypic transitions in fibroblasts and macrophages
… response. Interplay between M2a macrophages, myofibroblasts and M2c macrophages is responsible for the eventual resolution of this response. Following, transforming growth factor-β (TGF-β) activation, fibroblasts differentiate into myofibroblasts; these cells will secrete and contract …
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The role of microvesicles in EMT and tumour microenvironment
… derived-MV produced significantly high level of myofibroblasts marker alpha-smooth muscle actin (α-SMA) cytoskeleton protein and FGF. MVs were isolated from the myofibroblasts were enriched with α-SMA protein. Primary fibroblasts were treated with MVs released myofibroblasts expressed high level …
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Modulation of TGFβ1-induced Fibroblast-to-Myofibroblast Transition in response to Prostaglandin E2 Production by Human Rhinovirus-Infected Airway Epithelial Cells
… develop phenotypic characteristics of myofibroblasts. This increase in myofibroblasts leads to the excessive deposition of extracellular matrix proteins, leading to the thickening of the airway walls. Transforming growth factor beta-1 (TGFβ1) is highly expressed in asthmatics and is …
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Characterization and modeling of cell activation upon TGF-β1 stimulation in a 3-D culture system
… induce the conversion from normal fibroblasts to myofibroblasts and expression of a marker protein, alpha-smooth muscle actin (α-SMA). The cell response with TGF-β1 stimulation was captured with immunofluorescence staining (IF) and confocal microscopy imaging of α-SMA in each cell embedded layer. …
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Repair and restitution in the gastrointestinal tract after exposure to a cancer chemotherapy drug.
… impaired repair. Regulatory signals from myofibroblasts are essential for proper crypt development. In their absence, crypt regrowth would be disorganised, as seen after 5-fluorouracil. Chemotherapy-linked affects on myofibroblasts have not been reported before. Oral administration of …
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TARGETING FIBROBLAST-MATRIX INTERACTIONS TO TREAT VOCAL FOLD SCARRING
… a fibroblast-to-myofibroblast transition. While myofibroblasts are required for wound closure and VF repair, persistent myofibroblast activation results in the over-accumulation of a collagen-rich extracellular matrix (ECM), leading to tissue stiffening and scar formation. Patients experience …
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Identifying Functional Enhancers For Fibrotic Gene Regulation In Liver Fibrosis
… activation of proliferating and migrating myofibroblasts that lead to accumulation of extracellular matrix (ECM). These myofibroblasts most arise from activated liver-resident hepatic stellate cells (HSCs). There is an increasing number of patients suffering from liver fibrosis in developed …
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Smooth Muscle Hyperplasia Due to Acta2/Myh11 Mutations: Identification of Novel Pathology and Pathways Leading to Aneurysms and Diverse Vascular Occlusive Diseases
… To test this hypothesis, ACTA2 mutant SMCs and myofibroblasts were assessed and found to not form á-actin filaments whereas control cells did, suggesting a dominant negative effect of ACTA2 mutations on filament formation. A loss of á-actin filaments would be predicted to cause decreased SMC …
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Delayed Thrombus Resolution and Fibroproliferative Vascular Wound Healing From Deficiency of Type Iii Collagen: A Paradoxical Mechanism For Tissue Fragility
… and dysregulated behavior by resident myofibroblasts, culminating in the development of penetrating neovascular channels that disrupt the mechanical integrity of the arterial wall.</p> <p>Vascular injury and thrombus formation following ligation of the carotid artery reveals an abnormal …
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