Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 47 for “"Myofibroblast"”.
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Inhibition of myofibroblast contraction
… conduction. Layers of contractile cells known as myofibroblasts have been observed around regenerated nerve portions. An inverse relationship between the layer thickness and the quality of the regenerate has also been observed. These findings suggest that the cells are exerting contractile forces …
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Targeting the myofibroblast : new strategies in managing equine corneal fibrosis
… of equine corneal fibroblasts into myofibroblasts in vitro. This differentiaion of fibroblast to myofibroblast has been determined to be the major event responsible for corneal fibrosis, and is initiated by the presence of transforming growth factor beta. Our results indicate that …
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In vitro pharmacological inhibition of myofibroblast differentiation and force generation in a collagen-GAG matrix
… suggest an antagonistic relationship between myofibroblast-mediated contraction of wounds and induced regeneration. In each instance of induced regeneration, contraction blocking was accomplished using regeneration templates, or scaffolds of highly specific structural and chemical properties …
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Modulation of TGFβ1-induced Fibroblast-to-Myofibroblast Transition in response to Prostaglandin E2 Production by Human Rhinovirus-Infected Airway Epithelial Cells
… narrowing of the airway. Fibroblast-to-myofibroblast transition (FMT) is an airway remodeling phenomenon whereby fibroblasts develop phenotypic characteristics of myofibroblasts. This increase in myofibroblasts leads to the excessive deposition of extracellular matrix proteins, leading …
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A ROLE FOR ANGIOTENSIN-(1-7) TO ATTENUATE ADVANCED GLYCATION END PRODUCT -INDUCED MYOFIBROBLAST TRANSITION IN THE NRK-52E RENAL PROXIMAL TUBULE CELL LINE
… effects of MGA on cellular hypertrophy and myofibroblast transition; Ang-(1-7) reduced immunostaining and protein expression of á-smooth muscle actin by 60% (á-SMA) [n=3, p<0.05]. Moreover, Ang-(1-7) abolished AGE-induced activation of the MAP kinase ERK1/2 to a similar extent as the TGF-â …
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Fibroblasts: Key Cells in Inflammation and Fibrosis
… of TGFb, a cytokine that promotes fibroblast to myofibroblast transdifferentiation. We hypothesized that TGFb induces myofibroblast transdifferentiation via activation of fibroblast-RelA, an event that may precede the development of vascular inflammation and AAA formation. Using primary human …
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The role of nerve growth factor and p75 neurotrophin receptor in recovery from liver fibrosis
Rodent hepatic myofibroblasts are susceptible to nerve growth factor-mediated apoptosis through p75 neurotrophin receptor ligation. Hepatic myofibroblast apoptosis is critical to resolution of liver fibrosis. I show that human hepatic myofibroblasts exhibit differential responses to mature and …
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TARGETING FIBROBLAST-MATRIX INTERACTIONS TO TREAT VOCAL FOLD SCARRING
… cues, VF fibroblasts undergo a fibroblast-to-myofibroblast transition. While myofibroblasts are required for wound closure and VF repair, persistent myofibroblast activation results in the over-accumulation of a collagen-rich extracellular matrix (ECM), leading to tissue stiffening and scar …
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Modulation of TGFβ-Induced PAI -1 Expression by Changes in Actin Polymerization in Human Mesangial Cells
… quiescent glomerular mesangial cells into myofibroblast-like cells. The overall objective of this study is to delineate cellular mechanism/s of myofibroblast-differentiation in disease states. In cultured mesangial cells certain characteristics of myofibroblast differentiation (α-smooth …
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Stromal Fibroblasts Restrain The Rate of Colon Cancer Progression and Metastasis By Suppressing Regulatory T Cells and Colon Cancer Stem Cells
… ECM remodeling enzymes, and other metabolites. Myofibroblasts are a distinct subtype of fibroblasts characterized by expression α-smooth muscle actin (αSMA). These cells are a dominant component of the microenvironment, and a FSP1 and FAP could be a different clone of fibroblasts. Myofibroblasts …
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Modulation of Inflammation Driven Wound Healing after Glaucoma Surgery
… contributors to ocular morbidity – all with myofibroblast transdifferentiation and pathognomonic scarring activity at their core. This thesis aims to revaluate the means by which dysregulated ocular wound healing is combated with evidence describing a novel strategy to mitigate its effects. A …
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Repair and restitution in the gastrointestinal tract after exposure to a cancer chemotherapy drug.
… disruption of the intestinal sub-epithelial myofibroblast sheath, caused by 5-fluorouracil, impaired repair. Regulatory signals from myofibroblasts are essential for proper crypt development. In their absence, crypt regrowth would be disorganised, as seen after 5-fluorouracil. …
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Delayed Thrombus Resolution and Fibroproliferative Vascular Wound Healing From Deficiency of Type Iii Collagen: A Paradoxical Mechanism For Tissue Fragility
… and dysregulated behavior by resident myofibroblasts, culminating in the development of penetrating neovascular channels that disrupt the mechanical integrity of the arterial wall.</p> <p>Vascular injury and thrombus formation following ligation of the carotid artery reveals an abnormal …
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The Transformation of Human Retinal Pigment Epithelial Cells
… Slug expression. Furthermore, TGFβ induces myofibroblast markers (αSMA and CTGF), although vitreous suppresses their expressions. Vitreous also down-regulates the expression of TGFβ. The combination of TBI replicates the effect of vitreous as it decreases αSMA and CTGF. IL1β suppresses …
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A MECHANISM FOR CORTICAL BONE STEM CELL-DERIVED EXOSOMES’ THERAPEUTIC EFFECT ON POST-MYOCARDIAL INFARCTION REPERFUSION INJURY AND CARDIAC REMODELING
… mCBSC-derived exosomes cause a 40% decrease in myofibroblast activation in ARVFs compared to TGFβ activated controls. hCBSC-derived exosomes caused a 100-fold decrease in human fibroblast activation, implying an even stronger intraspecies anti-fibrotic effect. To further understand the signaling …
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Osteopontin and Cadherin 11 Are Novel Mediators and Drug Targets For Chronic Lung Diseases
… of extracellular matrix (ECM) proteins from myofibroblasts in airways. However, factors regulating myofibroblast biology are incompletely understood. Proteins in the cadherin family contribute epithelial to mesenchymal transition (EMT), a suggested source of myofibroblasts. Cadherin 11 …
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Synovial Fibrosis in Osteoarthritis of the Knee: Mechanism of Development and Potential Therapeutic Targets
… migration, proliferation and transition to a myofibroblast phenotype characterized by alpha smooth muscle actin (a-SMA) upregulation and stress fiber formation. Transforming growth factor-β (TGF-b) plays an important role in mediating the pathogenesis of synovial fibrosis. Synoviocytes produce …
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Mechanical modeling of tissue response during early stage entubulated peripheral nerve regeneration
… of fibroblasts which differentiate into the myofibroblast phenotype, forming concentric, force-applying layers collectively known as the contractile capsule around the periphery of newly forming tissue. The second group of cells includes undifferentiated fibroblasts, Schwann cells, and …
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Investigating the role of the complement system in the pathogenesis of sub-retinal fibrosis in neovascular age related macular degeneration
… this model, this thesis aimed to identify the myofibroblast precursors which contribute to macular fibrosis secondary to nAMD. <br/><br/>Macrophages have been identified as a key cell in macular fibrosis development. We saw an influx of infiltrating F4/80+ cells in the two-stage laser model …
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Biomolecules that impact phenotypic transitions in fibroblasts and macrophages
… response. Interplay between M2a macrophages, myofibroblasts and M2c macrophages is responsible for the eventual resolution of this response. Following, transforming growth factor-β (TGF-β) activation, fibroblasts differentiate into myofibroblasts; these cells will secrete and contract …
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