Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 42 for “"Myofiber"”.
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Effects of progressive resistance training on single myofiber calcium sensitivity in older women
… resistance training program (PRT) on single myofiber calcium sensitivity in older women. Five healthy older women between the ages of 67-82 with a mean age of 72.8±2.7 yr. participated in this study. The training regimen consisted of bilateral isotonic knee extensions. The subjects performed …
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Mapping crossing myofiber populations with Diffusion Spectrum Imaging in simulated and microfabricated model tissues
The ability to resolve complex myofiber populations is important for relating architectural structure with mechanical unction in muscular tissues. To address this issue, we sought to validate the capacity of Diffusion Spectrum Imaging (DSI), an MRI method for assessing molecular diffusion in a …
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α7β1 integrin regulation of skeletal muscle growth in response to mechanical loading
… as a mechanosensor and essential regulator of myofiber remodeling given its localization at the membrane and primary role in adhering the outer extracellular matrix to the inner actin cytoskeleton. However, additional work is necessary to affirm a primary role for the α7β1 integrin subunit in …
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Transcriptional Regulation of Muscle Contractility and Metabolism by a MicroRNA-Mediated Feed Forward Loop
… stimuli, skeletal muscle alters its myofiber composition to significantly affect muscle performance and metabolism. This process requires concerted regulation of myofiber specific isoforms of sarcomeric and calcium regulatory proteins that couple action potentials to the generation of …
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Using simulation to estimate probability density functions of bound water molecules with DSI
… channel with the internal compartment of the myofibers contained in an imaged mouse tongue. The simulated probability distribution function (PDF) for diffusion was specifically employed to estimate the myofiber diameter for the cells imaged by tissue imaging of the tongue by DSI. Our group …
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Control of Skeletal Muscle Fiber Types by Calcium Signaling Pathways
… metabolic and physiological specialization among myofiber subtypes. Previous studies have demonstrated that calcineurin activity is required to maintain slow myofiber identity. I am interested in determining the transcription factors downstream of calcineurin and other calcium-regulated signaling …
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Role of SH3 and Cysteine-Rich Domain 3 (STAC3) in Skeletal Muscle Development, Postnatal Growth and Contraction
… postnatal Stac3 deletion decreased the size of myofibers and increased the percentage of myofibers containing centralized nuclei without affecting the total myofiber number. Postnatal Stac3 deletion decreased limb muscle strength. Postnatal Stac3 deletion reduced electrostimulation- but not …
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A biomechanical investigation of the structure--function relationships in the human tongue
… is composed of various orthogonally oriented myofiber populations. Furthermore, coupling this knowledge of tissue myoarchitecture with patterns of regional deformation offers the ability to explore complex structure-function relationships in the organ. Tongue myoarchitecture was studied with …
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Heart failure and associated structural and functional remodeling: assessment employing various magnetic resonance imaging methodologies.
… tensor magnetic resonance imaging (DTMRI), myofiber orientation can be probed in high resolution and this technique has been successfully utilized to study the helical arrangement of muscle fibers within the myocardium. As such, the counter-wound helical structure of the myocardium is …
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Molecular Enhancement of Alpha 7 Integrin to Ameliorate Muscular Dystrophy
… cell content and cardiomyopathy and increased myofiber integrity. HTCB injected mice have increased myofiber integrity and show elevated alpha7 integrin expression in muscle. Together, these results represent important milestones towards developing an alpha7beta1 integrin based complementary …
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Dissecting the signaling and mechanical functions of the dystrophin-glycoprotein complex in skeletal muscle
… is unclear. To explore the mechanisms of myofiber necrosis in dystrophin-deficient muscle, we tested the hypothesis that restoration of the DGC without a link to the cytoskeleton could ameliorate dystrophic pathology. Transgenic mice were generated that express Dp116, a non-muscle isoform …
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Optimization of a pericyte therapy to improve muscle recovery following hindlimb immobilization
… transplantation can effectively recover myofiber size in mice. These data suggest that pericytes positively influence skeletal muscle growth and may represent a novel approach to the prevention and treatment of disability following disuse. However, one of the challenges in developing a …
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Expression and Putative Functions of Fibroblast Growth Factor 10 (Fgf10) in Developing and Adult Skeletal Muscles
… within each positive muscle, only a subset of myofibers expresses Fgf10. Immunolabeling with Pax7 antibodies showed that a subpopulation of Fgf10-expressing myonuclei expresses this satellite stem cell marker. To delineate the function of Fgf10, I examined the limbs of newborn Pax3- …
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Growth factors in extraocular muscles: effects on contractile properties
… biological properties, including specialized myofiber types, a unique transverse and longitudinal organization of myofibers, continued muscle plasticity and the retention of activated progenitor cells in adult normal muscles. Those biological features of contractile physiology enable them to …
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Effect of Denervation on the Regulation of Mitochondrial Transcription Factor a Expression in Skeletal Muscle
The most rapid decline in myofiber size and mitochondrial content during denervation, a muscle disuse model, occurs during the first week following the onset of the stimulus. In this study, we analyzed the expression of Tfam, a critical mitochondrial transcription factor involved in the …
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Development of a pericyte-derived extracellular vesicle therapy for the recovery of skeletal muscle mass following immobilization
… of rapamycin (mTOR) signaling pathway in the myofiber, a manner that is critical for increased rates of myofibrillar protein synthesis and gains in mass in response to exercise. However, stem and stromal cells residing in the microenvironment (extrinsic to the myofiber) may also contribute. …
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Regulation of skeletal myogenesis by the mTOR signaling network
… is composed of post-mitotic multinucleated myofibers. During embryonic skeletal myogenesis, cells in somites commit to myogenic lineage and differentiate into myoblasts, which then fuse to form multinucleated myofibers. Post-natal growth, repair, and maintenance of skeletal muscle are …
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Probing Tissue Microstructure Using Susceptibility Contrast Magnetic Resonance Imaging
… ascertain both the magnetic susceptibility and myofiber orientation of the tissue. The susceptibility anisotropy of myocardium was observed and measured by relating the apparent tissue susceptibility as a function of the myofiber angle with respect to the applied magnetic field. A multi-filament …
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Inactivation of Stac3 causes skeletal muscle defects and perinatal death in mice
… mice also displayed increased myotube and myofiber cross sectional area at P0 (P < 0.001) and E17.5 (P < 0.05) with disorganized fiber bundling. Overall, these data show Stac3 is necessary for development of viable offspring and suggest Stac3 plays a critical role in fetal development where …
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Multi-scale analysis of cardiac myoarchitecture
… structure. Mesoscale tract representations of myofiber orientation are generated from similarly aligned diffusion or autocorrelation vectors. These methods were applied to study induced myocardial infarction in the rat and hypertrophic cardiomyopathy associated with deletion of the gene for …
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