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Showing 1 to 8 of 8 for “"Myocytes, Cardiac"”.
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Mechanisms to enhance cardiac regeneration
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Cardiomyocyte Autophagy Is Induced by Protein Aggregation in Heart Disease
Autophagy is associated with diverse forms of myocardial stress. When I initiated my studies activators of this pathway had not been identified in the heart, nor was it clear weather autophagy is an adaptive or maladaptive response in the stressed myocardium. My initial research focused on …
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Doxorubicin Inhibits Cardiomyocyte Autophagic Flux by Suppressing Lysosomal Acidification
… autophagic flux in vivo and in cardiomyocytes in culture. This block was accompanied by robust accumulation of undegraded autolysosomes. Moreover, I went on to localize the site of block as a defect in lysosome acidification. To test the functional relevance of doxorubicin-triggered …
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RalGDS-Dependent Cardiomyocyte Autophagy Is Necessary for Load-Induced Ventricular Hypertrophy
… is a key participant in pathological cardiac remodeling. One common feature of cell growth and autophagy is membrane biogenesis and processing. The exocyst, an octomeric protein complex involved in vesicle trafficking, is implicated in numerous cellular processes, yet its role in …
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Discovery and Characterization of Genes Involved in Muscle Calcium Handling
… a 34-amino-acid transmembrane peptide with cardiac and slow-twitch muscle expression that we have named Dwarf Open Reading Frame or DWORF. Overexpression of this peptide in cardiac myocytes increases the peak calcium release during contraction while also increasing the rate of calcium …
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Molecular Regulation of Direct Cardiac Reprogramming
… massive heart attack can kill billions of cardiomyocytes. The heart has limited regenerative potential because adult mammalian cardiomyocytes cannot proliferate, therefore lost cardiomyocytes cannot be replaced. This causes permanent heart damage and results in decreased contraction properties to …
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Prevention of Duchenne Muscular Dystrophy by CRISPR/Cas Therapeutic Genome Editing
… and ultimately succumb to respiratory and cardiac failure in their mid-20s. The dystrophin gene was identified three decades ago and mutations in the DMD gene are well-characterized. However, there is no effective treatment for this debilitating disease. The CRISPR/Cas (clustered regularly …
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Congenital Heart Defect-Associated Enhancers Shape Human Cardiomyocyte Lineage Commitment
Pages vii-xiv are misnumbered as pages vi-xiii.