Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 149 for “"Myocytes"”.
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The electrophysiological effects of Endothelin-1 in human atrial myocytes
… on ICaL and action potentials in human atrial myocytes. Methods: Atrial myocytes were isolated enzymatically from samples of right atrial appendage obtained from consenting patients in sinus rhythm undergoing cardiac surgery. The nystatin-perforated whole cell patch clamp technique was used at …
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Post-translational modifications regulate β2-Adrenoceptor signaling in cardiac myocytes
… on β2AR signaling regulation in cardiac myocytes. We find that palmitoylation, the fatty acid modification of β2AR at cysteine 341 is not required for receptor targeting to the plasma membrane caveolae. Instead, both palmitoylation and GRK phosphorylation are required to mediate the …
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Reduction of Myocardial Stunning by in Situ Genetic Alteration of Myocytes
… and stable expression in skeletal and cardiac myocytes results from simple injection of DNA into muscle tissue. To test the possibility that overexpression of Superoxide dismutase (SOD) may decrease ischemia-induced reperfusion injury to myocytes, we injected a plasmid (PMTSOD) containing the …
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Protein Trafficking of BK Channel β1 Subunits in Cerebral Artery Myocytes
… channels (BK) are expressed in arterial myocytes to control arterial contractility. It is composed of pore- forming BKα and auxiliary β1 subunits. Auxiliary β1 subunits associate with BKα which modulate Ca<sup>2+</sup> sensitivity of BK channel. Previous data showed that BKα locates at …
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Effects of relaxin on the electrophysiological properties of isolated atrial myocytes
ETDs are only available to UIUC Users without author permission
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The Effects of Cocaine and Ecstasy on Cardiac Myocytes and the Intact Myocardium
… and normal heart function. Cultured cardiac myocytes (H9c2) and New Zealand White rabbits (Oryctolagus cuniculus) were used to measure the responses to various concentrations of cocaine or ecstasy at both the cellular and intact organ system levels. We observed that cocaine and ecstasy …
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Molecular Dissection of Hand2 During the Formation of Pacemaker-Like Myocytes During Direct Reprogramming
Pages v-vi are misnumbered as pages vii-viii.
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Receptor-Mediated Hypertrophic Signaling Via Protein Kinase D and Histone Deacetylase 5 in Adult Myocytes
… to re-program terminally differentiated myocytes to grow in length or width. The compensatory hypertrophic response can enhance cardiac output briefly due to increased work load. However, prolonged stress results in maladaptive changes in the heart and gradually deteriorates ventricular …
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ROLE OF ENDOTHELIN-1 IN THE REGULATION OF THE SWELLING-ACTIVATED Cl- CURRENT IN ATRIAL MYOCYTES
… are important sources of ROS in cardiomyocytes. Blocking NOX with apocynin or mitochondrial complex I with rotenone both completely suppressed ET-1-induced ROS generation and activation of ICl,swell, indicating that ROS from both NOX and mitochondria were required to activate ICl,swell, …
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The myocyte enhancer factor-2 (MEF2) family mediates complex gene regulation in skeletal and cardiac myocytes
… of acute Mef2 knockdowns in neonatal cardiomyocytes and uncovered a requirement for MEF2A and -D, but not MEF2C in cardiomyocyte survival. Comparative microarray analysis confirmed that, similar to skeletal myoblasts, the MEF2 family regulated distinct but overlapping gene programs in …
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The Ultrastructural and Abnormal Calcium Handling in Pulmonary Vein Sleeve Cells, Atrial and Ventricular Myocytes During Ageing
… Ca<sup>2+</sup> handling in PVCs and atrial myocytes. Whilst structural changes and alterations in the Ca<sup>2+</sup> homeostasis have been described previously in atrial myocytes, similar studies are still lacking in PVCs. Thus, this thesis investigated structural remodelling and …
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Insulin-Like Growth Factor-1 Regulation and Subunit Composition of Low-Voltage Activated Calcium Channels in Atrial Myocytes
… modulate the LVA Ca$\sp{2+}$ current in atrial myocytes. Our data showed that LVA Ca$\sp{2+}$ channels were inhibited by AS-$\rm\beta\sb{all}.$ These results support the idea that atrial T-type calcium channel is encoded by a member of the $\rm\alpha\sb{1E}$ calcium channel genes and is composed …
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Adenovirus-mediated gene transfer of FK506-binding proteins FKBP12.6 and FKBP12 in failing and non-failing rabbit ventricular myocytes
Die FK-506 Bindungsproteine (FKBP) können in Skelettmuskel (FKBP12) und Herzmuskel (FKBP12.6) die Kalziumfreisetzung aus dem sarkoplasmatischen Retikulum (SR) durch Bindung am Ryanodin Rezeptor (RyR) beeinflussen. FKBP12.6 bindet an den kardialen RyR (RyR2) und FKBP12 ausschließlich an den …
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Modulation of calcium channel expression in cardiac myocytes of rats during growth hormone-induced growth or normal postnatal development
Voltage-dependent Ca$\sp{2+}$ currents of cardiac myocytes were studied using patch-clamp techniques. T-type Ca$\sp{2+}$ current density of atrial myocytes was found to be positively correlated with the plasma growth hormone levels and the growth rate of atrial myocytes in normally developing …
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Sphingosine-1-Phosphate and Fingolimod (FTY720) Regulate ICl,swell In HL-1 Cardiac Myocytes via Intracellular Binding And Mitochondrial ROS Production
<p>Swelling-activated Cl− current (ICl,swell) is an outwardly-rectifying current that plays an important role in cardiac electrical activity, cellular volume regulation, apoptosis, and acts as a potential effector of mechanoelectrical feedback. Persistent activation of ICl,swell has been observed …
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The effects of Tumour necrosis factor-alpha and Interleukin-1-beta on intracellular calcium handling and contractility in sheep ventricular myocytes
… sensitivity to calcium.Sheep ventricular myocytes were used for all experiments. All procedures used accord with the Animals (Scientific Procedures) Act, UK, 1986 and Directive 2010/63/EU of the European Parliament. Intracellular calcium and contractility dynamics were measured by …
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Cellular mechanism of contractile dysfunction in the diabetic heart
… of experiments were carried out on ventricular myocytes following 8-12 weeks of STZ treatment. L-type calcium (Ca2+) current (ICa,L) was measured in patch clamped ventricular myocytes in whole cell mode, using a cesium-based pipette solution and a holding potential of -40 mV and test potentials …
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Ischemic Preconditioning Protects Adult Rat Cardiomyocytes Against Necrosis but not Apoptosis, via Activation of PKG
… in the ischemic preconditioning (IPC) of cardiomyocytes is not clearly defined. In the current study, we assessed the hypothesis that PKG protects against cell death following ischemidreperfusion injury in myocytes subjected to IPC. Freshly isolated adult rat ventricular myocytes were subjected …
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