Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 89 for “"Myocyte"”.
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Mathematical modelling of energy demand and supply in the cardiac myocyte
… the key energy-consuming processes in the cardiomyocyte. These models encapsulate both thermodynamic considerations and metabolite sensitivity into a cycle-based framework. The parameters of these models are constrained by experimental data which characterise their physiological behaviour. These …
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The myocyte enhancer factor-2 (MEF2) family mediates complex gene regulation in skeletal and cardiac myocytes
… of acute Mef2 knockdowns in neonatal cardiomyocytes and uncovered a requirement for MEF2A and -D, but not MEF2C in cardiomyocyte survival. Comparative microarray analysis confirmed that, similar to skeletal myoblasts, the MEF2 family regulated distinct but overlapping gene programs in …
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The Role of Phosphodiesterases in Cyclic Nucleotide Compartmentation Across Different Pathways in the Adult Rat Ventricular Myocyte
In cardiac myocytes, multiple receptor mediated signalling pathways converge on cyclic nucleotide production. These second messengers act to achieve changes in cellular function. Despite this, each signalling molecule and receptor can achieve distinct sub-cellular effects. This has led to the …
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The role of extracellular matrix in modulation of myocyte Ca2+ signalling and contraction in the isolated rat heart
… mechanical scaffolding for the contracting myocytes. However, it was observed that the amplitude of the intracellular Ca2+ transients that underlie contraction was reduced in isolated myocytes in comparison to Ca2+ transients from multicellular trabeculae. The role of ECM in myocyte Ca2+ …
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The Interaction of Early Growth Response Gene 1 and Myocyte Enhancer Factor 2C in the Murine Brain Cortex
… methylomes and predicted EGR1 may interact with myocyte enhancer factor 2C (MEF2C), which is known to be involved in many similar processes as EGR1, such as synapse architecture, cell migration, and learning and memory. EGR1 and MEF2C ChIP-seq data derived from mouse frontal cortex suggest these …
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An apparatus for high throughput muscle cell experimentation
The cardiac ventricular muscle cell (myocyte) is a key experimental system for exploring the mechanical properties of the diseased and healthy heart. The myocyte experimental model provides a higher level of physiological relevance than molecular or myofibril studies while avoiding problems …
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Gender Differences In Cardiomyocyte Remodeling and Adhesion In Response to Chronic Elevations In Myocardial Stress
… whether gender difference exists in cardiomyocyte remodeling during chronic volume overload (CVO) induced by aortocaval (AV) fistula. To this end, isolated cardiomyocyte dimension, sarcomere length, number of nuclei were measured in male and female rats after creation of an AV fistula. In …
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Investigating the Impact of Environmental Stressors on Skeletal Muscle Angio-Adaptation
… to the angiogenic relationship between the myocyte and endothelial cell was investigated. Cold-stress reduced the secretion of angiogenic molecules from the myocyte. Furthermore, cold-stress abrogated endothelial cells proliferation and attenuated VEGFR2 activation. Endothelial cells …
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Clinical utility of B-type natriuretic peptide (NP) in paediatric cardiac surgery: a systematic review
… is a hormone secreted primarily by ventricular myocytes in response in myocyte stretch or ischaemia.
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The Role of Angiotensin-(1-7) in the Modulation of Angiotensin II-Dependent Cardiac Remodeling
… The structural changes to the heart, including myocyte and vascular hypertrophy as well as interstitial and perivascular fibrosis, are attributed to a combination of both hemodynamic and humoral factors, such as angiotensin II (Ang II). Angiotensin-(1-7) [Ang-(1-7)] is an endogenous heptapeptide …
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The protective role of tumour necrosis factor alpha in the heart
… nuclear factor kappa B (NFₖ B) mediates this myocyte protection, the NFₖ B antagonists diethyldithiocarbamate (DDTC 10mM) or sodium salicylate (SA 100μM) were co-administered with TNFα. The myocyte protective effect of TNF a was significantly decrease with both antagonists, although not …
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The Role of the TBX5-driven Regulatory Network in the Manifestation and Sustainability of Atrial Fibrillation
… the electrical properties of atrial myocytes. Through the utilization of human atrial myocyte models, the mechanism by which the TBX5 network modulate the ionic mechanisms in the atrial myocyte can be elucidated. Furthermore, the models can be utilized to simulate the effects of …
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Thick filament regulation of myocardial contraction
… by mechanisms intrinsic to individual cardiac myocytes. The experiments in this dissertation were designed to examine the effects of sarcomere length and thick filament protein isoform expression on the contractile properties of single skinned cardiac myocytes. Myosin binding protein-C ablation …
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Cellular pathways of angiotensin II signalling in the hypertrophic myocardium
… signalling of the hypertrophic cardiac myocyte. Ventricular hypertrophy in the Dahl SS/Jr (Dahl S) rat was dependent upon the time on 6% NaCl diet. This was confirmed to be partly based on differences in viable myocyte size as determined by Fluorescence Activated Cell Sorting analysis. …
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Over-expression of NRF-1 in C2C12 myotubes increases GLUT4 content via a transcriptional cascade involving MEF2A
… mice increases glucose transporter (GLUT)-4 and myocyte enhancer factor (MEF-) 2A content, but the mechanisms have not been elucidated. Because NRF-1 has a binding site on the mef2a gene, and MEF2A binds the glut4 gene as a MEF2A-MEF2D heterodimer, the aims of this study were to determine whether …
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Quantifying Structural and Functional Changes in Cardiac Cells in an In Vitro Model of Diabetic Cardiomyopathy
… the biomechanical properties of cardiac myocytes and fibroblasts under a variety of hyperglycemic and hyperlipidemic conditions. We showed that our in vitro model of DC exhibits increased stiffness in myocytes, but not fibroblasts. We then developed an assay to measure cardiac myocyte …
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Modeling oxygen requirements in ischemic cardiomyocytes
… the viability of the myocardial muscle cell (myocyte) and its quantitative conditions during ischemia. Here, we explore the viability of heart cells using a model for cellular metabolism. We use this model to predict conditions that will sustain viable concentrations of adenosine triphosphate …
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Characterization of NADPH Oxidases in Uterine Smooth Muscle during Pregnancy
… is infiltrated by immune cells. Immune and myocyte activation rely on signal transduction via oxidation-reduction reactions and generation of reactive oxygen species (ROS). Nicotinamide adenine dinucleotide phosphate oxidases (Nox) are proteins responsible for the transport of electrons …
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Prenatal Cocaine Exposure and Cardiac Programming
… a premature exit of the cell cycle of cardiomyocytes and myocyte hypertrophy in the remaining cells. It is likely that multiple mechanisms may be involved in cocaine/hypoxia-induced apoptosis in the fetal heart. In a neonatal and juvenile offspring, prenatal cocaine exposure induced abnormal …
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