Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"Myocardin"”.
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Roles of Myocardin-Related Transcription Factors in Muscle and Brain
… between Serum response Factor (SRF) and its Myocardin Related Transcription Factor (MRTF) coactivators during development. I present here my studies on the functions of MRTFs during brain and muscle development. First, I show that MRTF-A and -B redundantly control neuronal migration and …
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Investigating the Impact of K+ Channel Expression on Mechanosurveillance of Disseminated Cancer Cells
… regulators of cellular stiffness downstream of myocardin related transcription factor A (MRTFA). In primary pericytes, KCNMB1 knockdown increased cellular stiffness, which is consistent with the role of potassium efflux in promoting relaxation during excitation-contraction coupling. In a …
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Identification of RBPMS as a smooth muscle master splicing regulator via association of its gene with super-enhancers
… as well as the key SMC transcription factor Myocardin. Structure-function analyses revealed that the two major RBPMS isoforms (RBPMS-A and B) have differential activity, and that dimerization and RBPMS C- terminus are essential to RBPMS splicing activity. Yet, RBPMS RRM was insufficient for …
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Serum response factor-dependent regulation of smooth muscle gene transcription
… I found that SRF transcription cofactor myocardin acts together with SRF to regulate expression of microRNAs-143 and 145 but not microRNAs-133a and 133b. SRF can, thus, further modulate gene expression through post-transcriptional mechanisms via changes in microRNA levels. Overall my …
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TARGETING FIBROBLAST-MATRIX INTERACTIONS TO TREAT VOCAL FOLD SCARRING
… VF myofibroblasts to fibroblasts to identify the myocardin related transcription factor A (MRTF-A)/serum response factor (SRF) signaling axis as required for VF myofibroblast activation. We demonstrate the therapeutic potential of MRTF-A/SRF inhibition across in vitro and in vivo models of VF …
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The Effect of Microenvironmental Cues on Adipocyte Cytoskeletal Remodeling
… actin stress fiber formation facilitated by myocardin-related transcription factor A (MRTF-A/MKL1) nuclear translocation. The second aim explores the effects of mechanical unloading (simulated microgravity) on key adipocyte functions and actin cytoskeletal remodeling. This study demonstrated …
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Effects of The Acta2 R258C Mutation On Vascular Smooth Muscle Cell Phenotype and Properties
… to wildtype SMCs and have predominantly nuclear Myocardin-Related Transcription Factor A (MRTF-A) localization. However, ultracentrifugation assays showed large unpolymerized actin fractions, suggesting that the filaments are brittle. In contrast, <em>Acta2<sup>+/- R258C TG</sup></em> SMCs are …
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Characterizing PIAS1 Function During Embryogenesis and Lung Cancer Progression
… cooperate with the cardiac transcription factors Myocardin and GATA-4 in promoting cardiac differentiation. Because Pias1 loss primarily affects erythrogenesis and vascular development of the YS, we also tested how conditional Pias1 deletion in endothelial cells of the YS would affect …
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Investigating the Mechanisms Underlying the Heterogeneous VSMC Contribution to Vascular Disease
In healthy blood vessels, vascular smooth muscle cells (VSMCs) exist in a contractile, quiescent state but upon vascular insult can switch phenotype to activate proliferation, migration and remodelling of the extracellular matrix. Phenotypically switched VSMCs contribute most cells within …