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Showing 1 to 7 of 7 for “"Myocardial stiffness"”.
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Acoustic Radiation Force Impulse Imaging of Myocardial Performance
… cardiac diseases, it is necessary to assess myocardial performance and function. One mechanical property that has been shown to reflect myocardial performance is myocardial stiffness. Acoustic radiation force impulse (ARFI) imaging has been demonstrated to be capable of visualizing variations …
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Model-based Analysis of Myocardial Microstructure for Left Ventricular Mechanics using MRI
… (HF) remain largely unexplained. Increased myocardial tissue stiffness, diffuse fibrosis, and tissue remodelling have been identified as contributors to HF. However, their biomechanical effects are not well understood. In this thesis, the link between intrinsic mechanical properties of the …
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Quantifying Structural and Functional Changes in Cardiac Cells in an In Vitro Model of Diabetic Cardiomyopathy
… structural and functional changes can appear in myocardial tissue, characterized by diastolic and systolic dysfunction, and eventually heart failure. While specific changes associated with DC are well characterized, the mechanism underlying disease development and progression as a whole remain to …
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Development of an experimental system to determine the contribution of titin and collagen to passive stiffness of myocardium
… The main contributors to increase in the myocardial stiffness, hindering the cardiac mechanics, are alterations in intracellular titin and extracellular collagen matrix. Titin is a giant extensible protein, the third filament of striated muscle after actin and myosin, which provides …
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Identification of Transversely Isotropic Material Properties from Cardiac Magnetic Resonance Elastography
Myocardial stiffness is an important determinant of cardiac function, and significant increases in global stiffness are thought to be associated with some forms of diastolic heart failure. Although magnetic resonance elastography (MRE) has been used to estimate isotropic stiffness in the heart, …
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Development and Application of Low-Order Computational Models of the Left Ventricle
… (LV) dynamics that allow rapid estimation of myocardial stiffness and contractility from echocardiogram data. To reduce the computational complexity of this inverse problem, we represent LV deformation in terms of a limited number of modes. In the first part of this work, we present a …
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Acoustic Radiation Force Impulse-Driven Shear Wave Velocimetry in Cardiac Tissue
… velocity of these waves is related to a medium's stiffness and thus can offer useful diagnostic information. Consequently, shear wave velocimetry has the potential to investigate cardiac disease states that manifest themselves as changes in tissue stiffness (e.g., ischemia).</p><p> The work …