Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"Myocardial ischaemia"”.
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Metabolism in myocardial ischaemia and reperfusion with specific reference to the role of glucose
… is known to be protective in moderate low flow ischaemia due to the production of glycolytic ATP. However, it is questioned whether glucose would still be protective in ultra-low flow ischaemia. Firstly, glycolysis is thought to be inhibited, and secondly, deleterious glycolytic metabolites …
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Reactive oxygen species and mitochondrial metabolism in acute myocardial ischaemia reperfusion injury: measurement and modulation
… to play a central role in the pathology of acute myocardial infarction (AMI), where their production is driven by the metabolism of the citric acid cyclic intermediate succinate that accumulates during ischaemia. This is a major driver of damage upon reperfusion of ischaemic tissue. ROS are …
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Effects of exercise training on left ventricular function and exercise capacity in patients with coronary artery disease and varying degrees of left ventricular dysfunction
… left ventricular dysfunction and/or residual myocardial ischaemia, and could become potential candidates for cardiac rehabilitation if exercise training could induce physiological benefits without further deteriorating their condition. Over the last 10 years, several patients at moderate to …
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Adaptive Mechanisms of the Heart to Ischaemic Stress
… mechanisms using the models of exercise induced myocardial ischaemia and acute myocardial infarction<br/>Methods<br/>Using a specially adapted supine ergometer, we used invasive physiological measurements and high-resolution cardiac magnetic resonance imaging to assess changes in coronary blood …
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The effect of patient warming on perioperative cardiovascular outcomes in interventional clinical trials: A systematic review and meta-analysis
… cardiovascular events, 1.07 (0.09; 13.03) for myocardial infarction, 0.56 (0.17; 1.85) for myocardial ischaemia, 0.48 (0.19; 1.20) for arrhythmias and 0.77 (0.25; 2.37) for all-cause mortality. Statistical heterogeneity was not concerning in any of the meta-analyses. All of the meta-analyses …
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Assessing the immune phenotype of cardiac syndrome x: a prospective study of biomarkers
… of angina pectoris with objective signs of myocardial ischaemia despite angiographically normal epicardial coronary arteries, appears to be due to coronary microvascular dysfunction and is known to be associated with an elevation of several inflammatory biomarkers, suggesting a possible role …
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Validation of first pass magnetic resonance myocardial perfusion imaging using fractional flow reserve
Background - Magnetic Resonance Myocardial Perfusion Imaging (MRMPI) has been used for the detection of reversible myocardial ischaemia in humans since the early 1990’s. This non-invasive method of diagnosing reversible myocardial ischaemia has a number of advantages over the other more commonly …
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Studies on the role of GPR55 in cardiovascular physiology and pathophysiology.
… can prove fatal with patients suffering lethal myocardial infarction or stroke. Recently, two studies investigating the role of G-protein-coupled receptor 55 (GPR55) in atherosclerosis reported conflicting results; one reported a pro-atherogenic role for GPR55 and the other, an anti-atherogenic …
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Determining the role of the LPI/GPR55 system in the development of obesity and associated cardiovascular consequences.
… the GPR55 knockout and HFD intervention on the myocardial infarct size sustained following a period of ischaemia/reperfusion (I/R) and 3) make use of an in vitro model to elucidate the mechanisms by which changes occur in the adipose tissue of mice fed a HFD. GPR55-/- mice fed a HFD for 12-weeks …
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Studies investigating the mechanisms of the cardioprotective effects of Cannabidiol.
The phytocannabinoid cannabidiol (CBD) has a complex pharmacology which is thought to include, but is not limited to, an ability to act as an inverse agonist at the CB1 and CB2 receptors and an antagonist of GPR55. Moreover, is has been shown to reduce infarct size and ameliorate reductions in left …
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Redefinition of uraemic cardiomyopathy with cardiac magnetic resonance imaging
… agents, tissue abnormalities particularly myocardial fibrosis, indicated by late gadolinium enhancement (LGE) may by identified. The work contained in this thesis examines the relationship between cardiac dimensions, as defined by CMR and cardiovascular risk factors (both conventional and …
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Wirkung angiogenetischer Wachstumsfaktoren auf regionale Funktion und regionale Perfusion am porcinen, chronisch-ischämischen Myokard
Trotz Verbesserungen in Prävention und Therapie bleibt die koronare Herzkrankheit (KHK) in den westlichen Industrieländern immer noch die häufigste Todesursache. Inhalt dieser Studie war die Induzierung einer Revaskularisation am porcinen, chronisch-ischämischen Myokard unter Verwendung von …
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Η ΕΠΙΔΡΑΣΙΣ ΤΗΣ ΙΣΟΠΡΟΤΕΡΕΝΟΛΗΣ Η ΤΗΣ ΜΥΟΚΑΡΔΙΑΚΗΣ ΙΣΧΑΙΜΙΑΣ ΕΠΙ ΤΟΥ ΜΑΓΝΗΣΙΟΥ ΤΟΥ ΜΥΟΚΑΡΔΙΟΥ ΕΠΙ ΥΠΑΣΒΕΣΤΙΑΙΜΙΑΣ: πειραματική μελέτη
THE AIM OF THIS WORK WAS THE STUDY OF MYOCARDIAL MAGNESIUM CHANGES AFTER ADMINISTRATION OF ISOPROTERENOL OR CORONARY ARTERY LIGATION DURING HYPOCALCAEMIA. WE USED 34 ANAESTHETISED DOGS (6 GROUPS) AND CONNECTED THEM WITH ARTIFICIAL KIDNEY. HYPOCALCAEMIA WAS ACHIEVED IN GROUPS B, D, F. INTRAVENOUS …