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Showing 1 to 20 of 78 for “"Myoblast"”.
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Understanding the Role of Loner in Myoblast Fusion
The general metadata -- e.g., title, author, abstract, subject headings, etc. -- is publicly available, but access to the submitted files is restricted to UT Southwestern campus access and/or authorized UT Southwestern users.
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Control of sex myoblast migration in C. elegans
… several migration processes in C. elegans, sex myoblast (SM) migration is an attractive system that has a simple and well-defined migratory route along the ventral side from the posterior to the precise center of the gonad. A multitude of guidance mechanisms control SM migration, many of which …
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Six1 Is Important for Myoblast Proliferation Through Direct Regulation of Ccnd1
… of Six1 expression significantly impairs primary myoblast proliferation and appears to impair satellite cell activation in response to muscle injury in vivo. Furthermore, loss of Six1 decreases the expression of key cell cycle genes. Combining functional genomics approaches such as ChIP-Seq and …
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Roles of proteasome, arachidonic acid, and oxytocin in bovine myoblast proliferation and differentiation
… factors and mechanisms that control bovine myoblast proliferation, differentiation, and fusion. Three studies were conducted during this project. The objective of the first study was to determine the effect of oxytocin (OXT) on myoblast proliferation, differentiation and fusion. Treating …
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An investigation into the genes mediating myoblast migration in the nematode : Caenorhabditis elegans
During C. elegans embryogenesis, myoblasts initially form two rows along the left and right lateral midlines and at ~290 min of development migrate dorsally and ventrally to form the four muscle quadrants present upon hatching (Sulston et al, 1983). As the myoblasts migrate they are still dividing, …
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Decellularized Apium graveolens Scaffold for Cell Culture and Guided Alignment of C2C12 Murine Myoblast
… on synthetic microchannels, I hypothesize that myoblast will not only align parallel to the vascular bundle but fuse into aligned myotubes. Results show that following 10 days in culture, the normalized orientation of F-actin filaments was determined to be 1.2 ± 2.0°. Subsequent to myoblast …
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Investigating the Function of an Actin Nucleation-Promoting Factor N-WASP in Mammalian Myoblast Fusion
Pages 61-89 are misnumbered as pages 75-103, and pages 90-100 are misnumbered as pages 102-112.
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Structural and functional studies of human ADAM 12 in myoblast fusion and Ebola virus VP40 in assembly
Part I:<br></br>ADAM 12 is a member of the growing ADAM protein family that displays a conserved domain organisation: a signal sequence, a pro-, a metalloprotease, adisintegrin, a cysteine-rich, a transmembrane and a cytoplasmic domain. ADAM proteins are found in higher eukaryotes and in most …
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Roles of cholesterol in the proliferation and differentiation of bovine myoblasts
… the proliferation and differentiation of bovine myoblasts. In the first experiment, myoblasts isolated from Angus or Angus crossbred steers were cultured with 2% lipoprotein deficient fetal calf serum (LPDS) or normal fetal calf serum. Culturing with LPDS did not alter the cytosolic or membrane …
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Role of JAK3 in Myogenic Differentiation
… are known to each have different effects on myoblast proliferation and differentiation; however, the role of JAK3 in myoblast differentiation remains unclear. In this study, we investigated the effect of JAK3 inhibition on myogenic differentiation in the C2C12 mouse myoblast cell line. During …
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Optimizing Ex Vivo Culture of Satellite Cells
… isolated satellite cells and of established myoblast cells with SR1 (Stemregenin 1, one of the compounds screened at the initial part of the thesis) results in inhibition of myogenic commitment factors, MyoD and Myogenin. SR1 also succeeded to block myoblast differentiation into myotubes. SR1 …
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Effects of three-dimensional culture conditions on skeletal muscle myoblasts
… Culture Conditions on Skeletal Muscle Myoblasts\r\n\r\nPublication No._____________\r\n\r\n\r\nMichele Lynn Marquette, Ph.D.\r\nThe University of Texas Medical Branch, 2007\r\n\r\nSupervisor: Marguerite A. Sognier\r\n\r\nThe objectives of this research were to: 1) develop a …
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Roles of Zinc in Skeletal Muscle Cells Growth
… the effects of zinc on IGFBP-3 inhibition of myoblast proliferation was examined. Zinc at concentrations that altered cell proliferation did not alter IGFBP-3 inhibition of IGF activity. The effects of extracellular zinc on IGF-1R signal transduction were examined using the non-membrane …
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Measurement of lipid peroxidation in biology models using gas-chromatography-aass spectrometry
<p>C2C12 mouse myoblast cells, grown in glass vials, were connected to a cryofocusing unit to trap volatile organic compounds (VOCs). The VOCs were eluted from the trap by capacitive discharge into a gas chromatograph with time-of-flight mass spectral capabilities (GC-TOFMS) and were found to …
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Cavβ1a in the Nucleus of Muscle Progenitor Cells: Mechanisms, Functions, and Implications
… we find that CaVbeta1a enters the nucleus of myoblasts, and knockdown of CaVbeta1a impairs myoblast proliferation in vitro and in vivo. To test if CaVbeta1a may regulate gene expression, we conducted microarray experiments on RNA extracted from wild type, heterozygous, and CaVbeta1 -null mouse …
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The role of myostatin during postnatal myogenesis and sarcopenia
… PCR analysis. In corroboration, treatment of myoblast cultures with exogenous myostatin resulted in the down-regulation of ARA70, confirming that myostatin is a negative regulator of ARA70 gene expression. The role of myostatin during sarcopenia, a progressive age-related loss of skeletal …
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Roles of Growth Hormone, Insulin-Like Growth Factor I, and Sh3 and Cysteine Rich Domain 3 in Skeletal Muscle Growth
… from cattle and allowed to proliferate as myoblasts or induced to fuse into myotubes in culture. GH increased protein synthesis without affecting protein degradation in myotubes; GH had no effect on proliferation of myoblasts; GH had no effect on IGF-I mRNA expression in either myoblasts or …
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The function of Drosophila Integrin-Dim7-Elmo-Mbc→Rac signaling pathway in the muscle attachment formation and maintenance
The Engulfment and Cell Motility (Elmo)-(Myoblast city) Mbc→Rac signaling pathway is evolutionarily conserved from C. elegans to vertebrates and is essential for many developmental processes, including phagocytosis and cell migration. Flies that possess mutations in the elmo locus are lethal and …
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Membrane-cytoskeleton associations during myogenesis
Several monoclonal antibodies directed at the myoblast cell surface either inhibited or promoted the fusion of L8E63 rat skeletal muscle cells in culture, and this suggests that the fusion of skeletal myoblasts is regulated by distinct, cell surface components. Such perturbations of myoblast fusion …
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