Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"Myf5"”.
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Epigenetic Regulation of Muscle Stem and Progenitor Cells
… mRNA expression in Mll1 KO myoblasts finds that Myf5 is the most strongly downregulated of all genes, unexpectedly, mRNA expression of previously identified MLL1 targets are unaffected by loss of MLL1 in myoblasts. Pax7 activates Myf5 expression through recruitment of a H3K4 HMT, and in Mll1 KO …
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ΕΠΙΔΡΑΣΗ ΤΗΣ ΜΗΧΑΝΙΚΗΣ ΦΟΡΤΙΣΗΣ ΣΕ ΦΥΣΙΟΛΟΓΙΚΟΥΣ ΚΑΙ ΓΗΡΑΣΜΕΝΟΥΣ ΣΚΕΛΕΤΙΚΟΥΣ ΜΥΟΒΛΑΣΤΕΣ
… C2C12. Μελετήθηκαν τα γονίδια MyoD, Myf5 και Myogenin ως δείκτες μυογένεσης, το Myostatin ως αρνητικός ρυθμιστής μυϊκής ανάπτυξης και ο παράγοντας Klotho, που έχει συνδεθεί με αντιγηραντικές ιδιότητες. Τα κύτταρα καλλιεργήθηκαν σε Passage 14 (φυσιολογικός φαινότυπος) και Passage 36 …
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Development of the ocular motor system in mouse embryos
… expressing the myogenic determinants Pitx2 and Myf5 near the eye. Contact between nerves and muscle precursors occurs days before mature muscle fibers have formed. The nerve remains in a plexus with these muscle precursor cells past the point of primary myogenesis, then infiltrates the mature …
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Genomic characterization of Six1 function during skeletal muscle differentiation
… skeletal muscle development, and comprise MyoD, Myf5, Myogenin and Myf6. Based on previous bioinformatics predictions, it was proposed that Six1 had a genome-wide function and cooperated with MRFs by co-regulating gene expression. A functional genomics approach (ChIP-on-Chip) was used to identify …
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Predicting molecular markers of development and regeneration through integrative analysis of high-throughput genomics data
… novel ncRNAs exhibiting potential control over Myf5 during myoblast differentiation.
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Identifying the signalling pathway of a novel Myostatin Splice Variant (MSV)
… multiple myogenic transcription factors (MyoD, Myf5, MRF4, Pax7 and Mef2) and the abundance and/or the phosphorylation of targets that have a metabolic role in skeletal muscle (rps6, 4EBP1 and p70S6K). Treatment with MSV increased the abundance of Smad 3, Myf5, 4EBP1 and stimulated AKTS⁴⁷³and …
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Elucidating Functional Roles For Myogenin In Adult Skeletal Muscle Metabolism, Exercise Capacity, and Regeneration
… myogenic transcription factors, myogenin, Myf5, MRF4, and MyoD are critical for embryonic skeletal muscle development. Myogenin is necessary for the terminal differentiation of myoblasts into myofibers during embryogenesis, but little is known about the roles played by myogenin in adult …
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Pax3 expression in satellite cells of avian skeletal muscle spindles during normal development and with experimental muscle overload
… maintain small diameters, developmental myosins, Myf5 expression and high SC concentrations. This thesis tests the hypotheses that Pax3 expression is preferentially maintained in SCs of adult skeletal muscle spindles and can be augmented under conditions of SC activation. To study Pax3 through …
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Funtional Analysis of the Murine Genes, MOCS1 and Sox15
… (myogenetic regulatory factor), während Myf5 hochreguliert wird. Hinweise auf die Fähigkeit von Sox15 Proteinen zur Bindung einer auf der distalen Regulationsregion von MyoD lokalisierten DNA binding site ergeben sich durch elektrophoretische mobility shift assays.Ähnlich wie ein MyoD -/- …
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Estudo de polimorfismos do gene candidato, fator miogênico-5 (myf-5), em suínos
Com o desenvolvimento de técnicas de biologia molecular e o uso dos marcadores de DNA, tem sido possível associar regiões genômicas com características de importância econômica. Algumas regiões genômicas possuem genes que exercem efeitos sobre determinada característica. Nessa mesma região, podem …
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Unraveling the molecular mechanisms of the class II transactivator, CIITA in skeletal muscle
… sequential ChIP assays show that MYOD, MYOG, and MYF5 co-occupy promoters. Taken together, my dissertation provides a comprehensive understanding of the molecular mechanisms during myogenesis and reveals the deleterious effects of chronic inflammation in skeletal muscle.
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Non-canonical functions of leucyl-tRNA synthetase: Mechanism of cell growth and skeletal myogenesis
… alternative strategy using tamoxifen-inducible Myf5-CreER driven Vps34 knockout in muscle cells of the offspring to investigate the role of Vps34 in the early stage of muscle regeneration. Additionally, I suggest an experiment to probe the in vivo involvement of the Vps34-PLD1-mTOR-IGF2 pathway …
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A genetic analysis of somitogenesis in the Medaka (Oryzias latipes)
… (e.g. mesp) and differentiation of somites (e.g. myf5, lfng) revealed that the medaka mutants can be separated into two classes. Class I shows defects in tailbud formation and PSM prepatterning, and lateron somite boundary formation was impaired in these mutants. A unique member of this class with …
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Studying the Patterning Mechanisms and Cell Fates during Limb Regeneration in Ambystoma mexicanum
We studied patterning mechanisms and cell fates during limb regeneration in the axolotl. 1) It is crucial to understand the earliest events of patterning. Since it is technically challenging to study early events, we established single cell PCR. This new tool will allow us to obtain novel insight …
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Effects of maternal supplementation of trace minerals and fatty acids on beef progeny
… birth to weaning for PUFA compared with CON; MYF5 in LM and C/EBPβ in adipose tissue tended (P ≤ 0.08) to decrease more from birth to weaning for CON compared with PUFA; SCD in PUFA adipose tissue tended (P = 0.08) to decrease to a greater extent from birth to weaning than CON. In addition, …