Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"Myeloproliferative disorder"”.
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CBL and CBL-B Dictate CSF-1R Endocytic Traffic and Signaling in Macrophages
… hyperproliferated, matching the severe myeloproliferative disorder observed in DKO mice. The CSF-1R and associated proteins were not ubiquitinated in DKO macrophages, unlike single knockouts and wild-type cells suggesting redundant functions of Cbl and Cbl-b. Mapping of the CSF-1R …
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Investigating a co-operative link between TGF-β and Lyn kinase in Chronic Myeloid Leukaemia
Chronic myeloid leukaemia (CML) is a myeloproliferative disorder characterised by uncontrolled proliferation of haematopoietic cells driven by the fusion gene Bcr-Abl. The advent of a mechanism specific kinase inhibitor, Imatinib, targeting the constitutively active Bcr-Abl kinase has paved the way …
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The analysis of Bcr-Abl—Nox signalling in chronic myeloid leukaemia
Chronic Myeloid Leukaemia (CML) is a myeloproliferative disorder characterised by increased proliferation of haematopoietic stem cells. CML results following generation of the chimeric protein Bcr-Abl, a constitutively active tyrosine kinase which induces oncogenesis in part by promoting increased …
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Biological Mechanisms and Clinical Implications of Bcr-Abl-Induced Mitochondrial Oxidative Stress and Cell Survival In Chronic Myeloid Leukemia
<p>Chronic myeloid leukemia (CML), a myeloproliferative disorder, represents approximately 15-20% of all adult leukemia. The development of CML is clearly linked to the constitutively active protein-tyrosine kinase BCR-ABL, which is encoded by <em>BCR-ABL</em> fusion gene as the result of …
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The human myeloproliferative disorders: molecular pathogenesis and clonal heterogeneity
The classical myeloproliferative disorders (MPD), comprising essential thrombocythaemia (ET), polycythaemia vera (PV) and idiopathic myelofibrosis (IMF), are clonal premalignant haematopoietic neoplasms associated with activating mutations in signalling pathway molecules and a variable tendency to …
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Gene expression profiling of patients with Polycythaemia Rubra Vera using cDNA microarrays
… a more global view of gene expression in this myeloproliferative disorder. Granulocyte RNAs from 40 polycythaemia vera (PV) and 12 secondary erythrocytosis (SE) patients were analysed. Peripheral granulocytes were chosen as the source of RNA, since these cells yield high amounts of RNA and …