Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 20 for “"Myelopathy"”.
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The spectrum of acute and subacute myelopathy
… of conditions responsible for acute and subacute myelopathy in South Africa. 2. To categorise the clinical presentations and prognosis of the illnesses and to correlate these with aetiology. 3. To assess the validity of diagnostic criteria for acute and subacute myelopathy in general and for the …
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Magnetic Resonance Based Imaging for Degenerative Cervical Myelopathy
Degenerative cervical myelopathy [DCM] is a progressive, spinal cord injury, estimated to affect 1 in 50 adults. Spinal cord compression from degenerative changes of the cervical spine, such as intervertebral disc prolapse, osteophyte formation or ligament thickening have been considered the …
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Engineering hiPSCs to enhance neural progenitor transplantation in degenerative cervical myelopathy
… as a treatment for degenerative cervical myelopathy (DCM), a non-traumatic form of spinal cord injury. Importantly, the extent of astrogliosis and extracellular matrix remodelling that could limit or enhance neural progenitor cell (NPC) graft efficacy in DCM is unknown. The first aim of …
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Cellular pathology and apoptosis in experimental and human acute and chronic compressive myelopathy.
… occurs in acute and chronic compressive myelopathy at various time points of compression, maximal at the site of injury.
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Chronic Pain after Non-traumatic, Non-compressive Myelopathy: Characteristics and Predictors for Neuropathic pain
… of the most common and serious consequences of myelopathy. The aim of this study was to survey chronic pain experience in a neurology out-patient clinic and to determine potential predictors for neuropathic pain after non-traumatic, non-compressive(NTNC) myelopathy. Methods: We analyzed54 …
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Investigating canine degenerative myelopathy as a disease model of amyotrophic lateral sclerosis for histopathological evidence of dysphagia
… was recently reported in dogs with degenerative myelopathy (DM), a proposed disease model of amyotrophic lateral sclerosis (ALS). The purpose of our study was to establish a clinicopathological correlation of dysphagia in canine DM. We investigated the brainstem nuclei involved in swallowing in …
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An Examination of the Roles of CX3CR1 and Microglia in a Mouse Model of Degenerative Cervical Myelopathy
Degenerative Cervical Myelopathy (DCM) is the most common form of spinal cord impairmentand is caused by a variety of degenerative or congenital changes in the osseous and soft tissue structures of the spine that result in progressive compression of the cervical spinal cord. DCM can be treated with …
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Dysphagia and recurrent laryngeal nerve injury in anterior cervical discectomy and fusion
… disorders commonly present with axial pain, myelopathy, radiculopathy or a combination of these symptoms. Surgical intervention is generally indicated in with failure of conservative management or with evidence of cord compression or myelopathy. Anterior cervical discectomy and fusion (ACDF) …
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Mikrochirurgische Therapie zervikaler Bandscheibenvorfälle : Nachuntersuchung von 140 operierten Patienten
… (75%) patients with radiculopathy, 14 (10%) with myelopathy and 21 (15%) patients with a combined symptomatology were followed up one to four years postoperatively. A soft disc lesion was found in 55 (39%) patients, a hard disc lesion in 42 (30%) patients. 43 (31%) showed a combined hard-/soft …
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Darifenacina versus Estimulação Elétrica Transcutânea Parasacral para Tratamento da Síndrome da Bexiga Hiperativa Neurogênica em Individuos Infectados pelo HTLV-1
… individuals infected with HTLV-1 with associated myelopathy and in 59% of infected individuals without motor impairment. Anticholinergic medications are widely used to treat OAB symptoms, but the frequency of adverse events such as constipation, dry mouth, visual and mental disturbances, and even …
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Standardizing a freely-behaving canine videofluoroscopic swallow study protocol to investigate dysphagia in primary aging and neurological diseases
… seven conditions: control, canine degenerative myelopathy, Batten disease, cricopharyngeal dysfunction, cerebellar ataxia, megaesophagus, and dysphagia of an unspecified etiology. Healthy controls dogs were further divided into three age groups: juvenile (1 month to less than or equal to 1 …
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Study of the DNA Damage Complexes Within the HTLV-1 Tax Oncoprotein Interactome
… T-cell leukemia (ATL) and HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP). Tax is a virally encoded oncoprotein that is involved in HTLV-1 mediated cellular transformation. It has been hypothesized that Tax induces genomic instability via repression of the cellular DNA …
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Recovery of Ambulation in Medically Managed Thoracolumbar Disc Extrusions in Non-Ambulatory Small Dogs
… Although we have been aware of this type of myelopathy as far back as the 1890s, there remains debate regarding the appropriate treatment for affected dogs. Currently available treatments are categorised as either surgical or conservative but to date, these treatment options have never been …
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Deephtlv: A Deep Learning Framework For Detecting Human T-Lymphotrophic Virus 1 Integration Sites
… leukemia/lymphoma (ATL) and a HTLV-1 associated myelopathy or tropical spastic paraparesis (HAM/TSP). As part of its normal replication cycle, the genome is converted into DNA and integrated into the genome. With several hundreds to thousands of unique <strong>v</strong>iral …
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Isolation and Functional Mapping of Human T-Cell Leukemia Virus Type 1 Tax Oncoprotein DNA-Damage Complexes
… T-cell Leukemia (ATL) and HTLV-1 Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP). Cellular transformation can be caused by a single viral <em>trans</em>-activating protein, Tax. Tax may contribute to transformation through interaction with components of the DNA damage response …
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Improving the Knowledge of EPM
… such as EPM and cervical vertebral stenotic myelopathy (CVSM). When sCD14 levels were assessed in control EPM, CVSM, and EPM+CVSM horses, sCD14 concentrations in the cerebral spinal fluid (CSF) were significantly different between control and EPM horses and EPM horses and CVSM horses. With …
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HTLV-1 bZIP FACTOR ACTIVATES MYOFERLIN EXPRESSION TO FACILITATE HTLV-1 INFECTION AND MIGRATION OF INFECTED T-CELLS
… T-cell Leukemia (ATL) and HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP). The viral protein HBZ is consistently expressed in infected individuals and plays a crucial role in viral persistence and disease progression. This dissertation investigates the role of the cellular …
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Simulated Automobile and Rotary-Wing Aircraft Impacts: Dynamic Neck Response after Surgical Treatment for Cervical Spondylosis
… presenting as axial neck pain, radiculopathy, myelopathy, or any combination of the three. When conservative treatment does not adequately manage these symptoms, surgical intervention may be required. The longstanding surgical treatment for cervical degeneration is arthrodesis achieved through …
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Subcellular Localization of Human T-cell Leukemia Virus Type 1 Tax Oncoprotein
… subneoplastic conditions such as HTLV-Associated Myelopathy/Tropical Spastic Paraperesis (HAM/TSP). In ATL, the transformation and immortalization of T-lymphocytes has been attributed to the expression and activity of a single HTLV-1 viral protein, namely the <em>trans</em>-activating protein Tax. …
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Mielopatía inducida por quimioterapia intratecal en pacientes con leucemia linfoide aguda, hallazgos en resonancia magnética, serie de casos
El uso de quimioterapia intratecal no está exento de generar efectos adversos, cuya aparición puede variar desde pocas horas, hasta varias semanas. En la médula espinal, la mielopatía progresiva es un efecto secundario poco común pero que puede tener un desenlace devastador. Se presentan tres …