Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 149 for “"Myeloid leukemia"”.
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Immunotherapy and immunosuppression in myeloid leukemia
Acute myeloid leukemia (AML) and chronic myelomonocytic leukemia (CMML) are potentially life-threatening blood cancers characterized by the expansion of malignant myeloid cells in bone marrow and other organs. This thesis aimed at contributing to the understanding of the role of natural killer (NK) …
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Deciphering the Pathogenesis of Acute Myeloid Leukemia
Acute myeloid leukemia (AML) is a malignant disorder of the blood system. Hematopoietic stem cells (HSCs) supply and maintain this system by differentiating via intermediates into lineage-restricted progenitors that strongly proliferate to keep up with the high turn-over of mature blood cells. In …
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Treatment Response Prediction in Acute Myeloid Leukemia Patients
Predicting acute myeloid leukemia (AML) patient treatment response has the potential to impact clinical decisions. A prediction given at the time of diagnosis for treatment response can assist physicians in making effective treatment decisions and improving patient prognosis. This project aimed to …
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Functional Modeling of Genes Upregulated in Chronic Myeloid Leukemia
Chronic myeloid leukemia (CML) is caused by the transformation of a primitive hematopoietic cell by the BCR/ABL1 fusion gene that is formed through the chromosomal translocation t(9;22). CML is currently successfully treated with tyrosine kinase inhibitors targeting the ABL1 kinase domain. However, …
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Regulation of Myeloid Leukemia Cells by Platelet Factor 4
… to be the main drivers of relapse in Acute Myeloid Leukemia. LSCs ability to retain key properties of healthy hematopoietic stem cells (HSCs) means they are quiescent, chemo-resistant, and able to repopulate eradicated leukemic blasts, making LSCs an important target in AML. However, their …
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NON-GENETIC MECHANISMS OF CHEMORESISTANCE IN ACUTE MYELOID LEUKEMIA
Acute Myeloid Leukemia (AML) is the most common type of acute hematological malignancy in adults. 40–60% of patients relapse due to the emergence of cellular resistance to anti- leukemic drugs. Drug resistance in leukemic cells has been associated with intratumoral heterogeneity, among which …
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The Cell-Essentiality of KAT7 in Acute Myeloid Leukemia
Acute myeloid leukemia (AML) is an aggressive hematopoietic malignancy, characterized by the uncontrolled proliferation and differentiation arrest of myeloid progenitors. Chemotherapy has been the front-line treatment for decades and cure remains elusive for the majority of AML patients. …
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Investigating the Therapeutic Potential of L-asparaginase in Myeloid Leukemia
Acute myeloid leukemia (AML) is a malignant disease of the bone marrow that results in the proliferation and accumulation of dysfunctional myeloid cells and the disruption of the normal hematopoietic process. The high rate of relapse and diversity of the disease at the genetic and epigenetic level …
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CELLULAR AND MOLECULAR MECHANISMS OF CHEMORESISTANCE IN ACUTE MYELOID LEUKEMIA
Acute Myeloid Leukemia (AML) remains an incurable disease, with a 5-year survival rate below 30%. While the introduction of new therapeutic approaches, such as targeted therapies and immunotherapy, has had a modest impact on AML prognosis, the standard treatment of AML is still based on …
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Targeting Apoptotic Pathways to Overcome Drug Resistance In Acute Myeloid Leukemia
… that BCL-2 protein is highly expressed in acute myeloid leukemia (AML) cells. BCL-2–specific inhibitor ABT-199 potently induces mitochondrial apoptosis in AML cells and effectively kills AML stem/progenitor cells. Our biomarker studies demonstrate that both BH3 profiling and the expression …
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Aberrant epigenetics in the molecular pathogenesis of human acute myeloid leukemia
… by promoter hypermethylation in human acute myeloid leukemia (AML) and to study the mechanism of promoter hypermethylation mediated gene silencing. Interestingly, the cyclin dependent kinase inhibitor p15 was found to be methylated at a high frequency in AML patients and cell lines in …
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Inhibition of Mitochondrial Translation as a Therapeutic Strategy for Acute Myeloid Leukemia
… translation as a therapeutic strategy for acute myeloid leukemia Marko Škrtić Doctor of Philosophy Institute of Medical Science University of Toronto 2012 Abstract Intro: Acute myeloid leukemia (AML) therapies have remained unchanged for 20 years, and thus new therapies are needed. Objective: To …
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Cytogenetic abnormalities in Acute Myeloid Leukemia in Sweden. A population based study.
The impact of cytogenetic findings in AML was analyzed in the large population-based Swedish AML registry. Karyotypic patterns differed by age: t(8;21), inv(16) and t(11q23) were more common in younger patients, whereas loss of 5q, 7q and 17p, monosomal karyotype (MK) and complex karyotype (CK) …
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Preclinical Studies of A Novel Idh1 Inhibitor In Acute Myeloid Leukemia (Aml)
… Dehydrogenase 1 (IDH1) inhibitor in Acute Myeloid Leukemia, it</strong> <strong>is more effective than Ivosidenib (AG120) and has a potent anti-leukemic effect against IDH1 mutant acute myeloid leukemia in combination with Venetoclax (ABT-199).</strong></p> <p>Acute myeloid Leukemia (AML) …
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Oncogenic roles of RAS in acute myeloid leukemia cooperated with Mll-AF9.
… hematopoietic progenitor cells (HPC) as well as myeloid and lymphoid lineages by live mouse imaging and relative light unit measurement before or after treating Vav-tTA ; TRE -luciferase co-transgenic mice with doxycycline (Dox). We found that B cells in the bone marrow and T cells in the thymus …
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AML1/ETO Downregulates the Transcription Factor PU.1 in Acute Myeloid Leukemia
… translocation t(8;21) and found in 15% of acute myeloid leukemia patients. Here, we report a negative functional impact of AML1-ETO on the transcriptional activity of PU.1, an important transcription factor for normal myeloid differentiation. We have demonstrated that AML1-ETO interacts with PU.1 …
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