Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 55 for “"Myeloid cell"”.
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Endogenous Mechanisms Regulating Myeloid Cell Mediated Inflammation During Acute Lung Injuries
… to limit excessive pulmonary inflammation in myeloid cells using a mouse model of sepsis-associated ALI. In the first approach we screened for microRNAs during the recovery phase of ALI that could potentially regulate inflammation. We found that miR-147 is highly expressed during the recovery …
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The Role of Insulin-Like Growth Factor-I in Myeloid Cell Differentiation
… and its protein are specifically induced as myeloid progenitor cells undergo differentiation toward macrophages. However, the potential role of IGF-I in myeloid cell differentiation has not yet been investigated. The data in this thesis demonstrate that IGF-I combined with either RA or …
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Human myeloid cell and innate lymphocyte responses to mycobacterial vaccination or infection
… immune responses beyond conventional T cells in the context of BCG vaccination and tuberculosis disease.
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Investigation of ACE-overexpression in Myeloid Cell Lines through Whole-Proteome Analysis
… to the C-domain as the main proponent. The myeloid cells have enhanced reactive oxygen species (ROS) generation, pro-inflammatory cytokine production and phagocytosis with increased ATP and TCA cycle intermediate production. ACE overexpressing macrophages also improve cognitive ability in …
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Engineering Myeloid Cell Phenotype Using Cell Surface-Adhered Microparticles for Therapeutic Applications
Cell-based therapies present a new frontier for treating previously untreatable diseases. Living cells can innately overcome biological barriers, respond in real-time to biological stimuli, interact with specific cell types, and provide a canvas for further cellular engineering. The crucial role of …
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Tobacco/HIV-1-Induced Myeloid Cell-Derived Extracellular Vesicles in HIV-1 Pathogenesis
… replication is still poorly understood. Extracellular vesicles (EVs) have recently gained attention for their unique nature as intercellular messengers which can package proteins, nucleic acids, lipids etc. EVs are known to alter HIV-1 pathogenesis through intercellular communication. Until …
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MODELING AND MODULATING MYELOID CELL-MEDIATED NEUROINFLAMMATION FOLLOWING HUMAN IMMUNODEFICIENCY VIRUS-1 INFECTION
Human immunodeficiency virus 1 (HIV) infects myeloid cells in the central nervous system (CNS) and establishes a reservoir that persists despite antiretroviral therapy (ART). Infection leads to a 30-50% risk of developing HIV-associated neurocognitive disorders (HAND), a collection of mood, motor, …
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Studying Myeloid Cell Heterogeneity After Spinal Cord Injury via Time-Resolved Single-Cell RNA Sequencing
… system (CNS) resident microglia and infiltrating myeloid cells. However, the precise role of these myeloid cell subsets remains unclear as upon crossing the blood-spinal cord barrier (BSCB), infiltrating monocyte-derived macrophages may take on the morphology of microglia, and upregulate canonical …
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Il-1Α Blockade Reduces Immune Suppression In The Early Tumor Micro-Environment
… However, a major barrier against effective T cell mediated cytotoxicity is immunosuppression in the tumor micro-environment. It has been described that tumors secrete pro-inflammatory cytokines capable of modulating immune responses that favors the growth of tumor cells. Specifically, IL-1 …
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TREM-2 Expression and Regulation in Inflammation and Ischaemia
Triggering receptor expressed on myeloid cells – 2 (TREM-2) is a receptor expressed mainly in myeloid cells. TREM-2 is involved in the resolution of inflammation through dampening Toll-like receptor (TLR) induced pro-inflammatory cytokine secretion and phagocytic functions. It is increased in …
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Monocyte Modulation of Disease Pathogenesis and Progression in Localized Aggressive Periodontitis
… form of periodontitis characterized by a unique myeloid cell phenotype. In addition to its bacterial origin, the unique phenotype of the myeloid cell contributes to disease pathogenesis and progression through mechanisms mediating host inflammatory and immune responses. LAgP monocytes synthesize …
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Role of Bruton’s Tyrosine Kinase and Interleukin-6 in Plasma Cell Accumulation and Autoantibody Production in Lyn-Deficient Mice, A Model of Lupus
… of SLE, including peripheral plasma cell accumulation, anti-dsDNA antibodies, and GN. Lyn is a Src-family tyrosine kinase that, in general, inhibits B cell and myeloid cell activity. Loss of Lyn results in cellular hyperactivity associated with autoantibody production. Bruton’s …
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Loss of Ptdss1 in tumor cells improves anti-PD-1 therapy
… anti-PD-1 therapy. Depletion of PTDSS1 in tumor cells increased expression of IFNγ-regulated genes, including B2m, Cxcl9, Cxcl10, and Stat1. Loss of PTDSS1 in tumor cells also led to increased expression of MHC-I, which was associated with increased expression of cytolytic function related genes …
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Effect of pomegranate extracts on apoptosis and cell cycle in haematological malignancies.
… the uncontrolled proliferation of haematopoietic cells and progressive accumulation of these cells within the bone marrow (BM) and secondary lymphoid tissues. The exact cause of leukaemia remains unknown. Leukaemia is a major problem worldwide affecting many people each year. However, current …
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Myeloid cells induce neurofibromatosis type 1 aneurysm formation through inflammation and oxidative stress
… activity in both hematopoietic and vascular wall cells, which are critical for maintaining blood vessel homeostasis. NF1 patients are predisposed to chronic inflammation and premature cardiovascular disease, including development of large arterial aneurysms, which may result in sudden death …
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Potentiation of The Immune Checkpoint Blockade Response By Metabolic Modulation Is Predictable Using Molecular Imaging
<p>Unregulated cell division is a hallmark of cancer. The high metabolic needs of the tumor cells result in nutrient depletion and produce a hostile tumor microenvironment (TME) for antitumor immune cells, protecting the tumor from immune cell-mediated control and immunotherapy. Two of these …
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Myeloid-Specific ARNT Signaling Drives Sex-Based Differences in Acrolein-Induced Pulmonary Toxicity
This dissertation investigates the role of myeloid-specific ARNT in modulating the pulmonary immune response to acrolein, a highly reactive environmental toxicant. Using a murine model with myeloid-specific overexpression of Arnt-a (homolog of human ARNT isoform 1), this study characterizes both …
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Assessing The Outcomes of Blocking Ccl2-Ccr2 Signaling Axis On Breast Cancer Brain Metastasis
… downregulation in metastatic breast tumor cells activates PI3K/NF-ƙB signaling and increases the secretion of the chemokine CCL2, which enhances the chemotaxis of CCR2<sup>+</sup> myeloid cells, a major subpopulation of bone marrow-derived myeloid cells (BMDMs), from peripheral blood into …
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Group 2 innate lymphoid cells and reproduction
… showed that tissue-resident innate lymphoid cells (ILCs) are crucial regulators of both physiology and pathology of the tissues they populate. Uterine natural killer (uNK) cells are a subtype of ILCs known to regulate trophoblast invasion, uterine vascular adaptation to pregnancy, and foetal …
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