Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"Myeloid Malignancy"”.
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Investigating the translational and metabolic reprogramming of the bone marrow niche in myeloid malignancy
In acute myeloid leukaemia (AML), malignant cells surviving chemotherapy rely on high mRNA translation and their microenvironmental metabolic support to drive relapse. However, the role of translational reprogramming in the niche was, until now, unclear. This study found that relapsing AML cells …
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Clinical Utility and Impact of Targeted Nucleic Acid Sequencing in Myeloid Malignancies and Precursor Lesions
… of several genes recurrently mutated in myeloid malignancies, including myelodysplastic syndromes (MDS), myeloproliferative neoplasms (MPN) and acute myeloid leukemia (AML), with expanding diagnostic and clinical significance. Given the breadth of genetic aberrations required to diagnose …
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Investigating clonal hematopoiesis in rhesus macaque and human
… error-corrected sequencing of 56 human CH/myeloid malignancy genes, we identified natural CH driver mutations in aged RMs matching genes somatically mutated in human CH, with *DNMT3A* and *TET2* mutations being the most frequent. Of the 60 aged RM (median age of 25 years), 12 (20%) were to …