NDLTD logo NDLTD Union Catalog and Global ETD Search

Global ETD Search

Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.

Results

Showing 1 to 20 of 21 for “"Myelodysplastic Syndrome"”.

  1. In Vivo Functional Significance of Ccat2 Long Non-Coding Rna In Myelodysplastic Syndrome

    SHAH, MAITRI Y2016

    <p>Long non-coding RNAs form the largest part of the mammalian non-coding transcriptome and control gene expression at various levels including chromatin modification, transcriptional and post-transcriptional processing. Although the underlying molecular mechanisms are not yet entirely understood, …

    uthsc Repository record

  2. PATTERN OF INNATE IMMUNITY IN PATIENTS AFFECTED BY MYELODYSPLASTIC SYNDROME (MDS) EITHER BEFORE ANDAFTER HEMATOPOIETIC STEM CELL TRANSPLANT (HSCT)

    CALVI, MICHELAUniversità degli Studi di Milano2023

    Myelodysplastic syndromes (MDS) are a heterogenous group of myeloid neoplasms that primarily affect elderly people and, in the context of population aging, MDS incidence is set to increase substantially. MDS patients have a variable risk of progression to acute myeloid leukemia (AML) and are …

    milano Repository record

  3. Role of Selected Plasma MicroRNAs as Diagnostic and Prognostic Biomarkers in Myelodysplastic Syndrome // Роля на подбрани плазмени микроРНК-и като диагностични и прогностични маркери при миелодиспластичен синдром

    Atanasova, Svilena, Атанасова, СвиленаMedical University of Varna2025

    … diagnostic and prognostic biomarkers in myelodysplastic syndrome (MDS). The study aims to investigate the expression of these five microRNAs in the plasma of patients with MDS and healthy controls, and to analyse their correlation with clinical, laboratory, and prognostic parameters, …

    varna Repository record

  4. Outcome of Severe Aplastic Anemia Treated with Immunosuppressive Therapy Compared with Bone Marrow Transplantation

    김, 형일2011

    … myeloid leukemia developed in 1 patient and myelodysplastic syndrome developed in 2 patients. In the BMT group, response rate was 92.0%(18 complete remission, 5 partial remission) (p<0.001). 6 patients developed grade II to III acute graft-versus-host-disease (GVHD) and 3 patients developed …

    ajou Repository record

  5. Evaluation of the actin architecture in dysplastic megakaryocytes expressing the NUP98-HOXD13 leukemic fusion gene

    Okyere, BenjaminVirginia Tech2013

    Some myelodysplastic syndrome (MDS) patients present with macrothrombocytopenia due to impaired megakaryocyte (MK) differentiation. Transgenic mice that express the NUP98-HOXD13 (NHD13) fusion gene is a model for MDS and recapitulates the key features of MDS. The study investigated the hypothesis …

    vt Repository record

  6. Incidence and Clinical Relevance of Abnormal Complete Blood Counts in Survivors of Childhood Cancer

    Long, Zsofia Banhegyi2010

    … hemoglobin=27%. None of the patients developed myelodysplastic syndrome or a secondary leukemia during the follow-up period. Exposure to epipodophyllotoxins was associated with an increased risk of having abnormally high MCV values. CONCLUSIONS: Mildly abnormal CBC values are common in survivors …

    utswmed Repository record

  7. Assessing Patient Attitudes to ward Genetic Testing For Hereditary Hematologic Malignancy

    Johnson, Addison, <p>https://orcid.org/0000-0001-6172-5804</p>2021

    … with a common acute or chronic leukemia, myelodysplastic syndrome, or aplastic anemia. Principal component analysis (PCA) was used to analyze patient attitudes; distress was measured through the Impact of Event Scale-Revised (IES-R). Associations of distress and attitudes toward genetic …

    uthsc Repository record

  8. Targeting integrin alpha 5 and focal adhesion kinase to overcome azacitidine resistance in higher risk myelodysplastic syndromes

    Vaughan, LachlinUNSW, Sydney2024

    Myelodysplastic syndromes are typified by bone marrow failure due to profoundly impaired haematopoietic differentiation with higher risk disease commonly progressing to acute myeloid leukaemia. Azacitidine (AZA) and decitabine are the only available therapies for higher risk myelodysplastic …

    unsw Repository record

  9. Investigating the molecular dynamics of gene re-silencing following treatment with epigenetic therapies

    Patil, VibhaUNSW, Sydney2015

    … (5-Aza-dC) are approved for the treatment of myelodysplastic syndrome and show promise in the treatment of solid tumours. These therapies are thought to exert their anti-tumour effects by reactivating hypermethylated genes. However, resistance to these drugs inevitably develops and this is …

    unsw Repository record

  10. The Effects of TET2-Deficiency on Neutrophil Gene Expression and Function

    Luo, Michael2020

    … potential (CHIP), a potential precursor to myelodysplastic syndrome (MDS), affects over 10% of adults over 65. Loss-of-function ten-eleven-translocation methylcytosine dioxygenase 2 (TET2) variants are common in CHIP and associate with epigenetic dysregulation, inflammation, and …

    queens Repository record

  11. Evaluating the Clinical and Financial Impact of Multi-Gene Panel Testing

    Haque, Waqas Zia2023

    … types were breast (20%), colorectal (18%), and myelodysplastic syndrome (9%). 20% of patients (20/100) were found to have an actionable mutation and 2 patients were enrolled in clinical trials due to Foundation Medicine testing. Among the 20 patients with an actionable mutation, 5 of them (25%) …

    utswmed Repository record

  12. NF-kB Inducing Kinase (NIK) Influences Eosinophil Development, Survival, and Plasticity

    Trusiano, Briana LynnVirginia Tech2024

    Hypereosinophilic (HES) syndrome is an umbrella term encompassing several disease subsets that affects humans and veterinary species, ultimately resulting in >1,500 eosinophils/uL circulating in the blood documented over six-months. This eventually culminates in end-organ infiltration and increased …

    vt Repository record

  13. The Role of Hspa9 in Mouse Hematopoiesis and IL-7 Receptor Signaling

    Krysiak, Kilannin2016

    … a commonly deleted region (CDR) associated with myelodysplastic syndrome (MDS), a clonal hematopoietic stem cell disorder. Cytogenetic abnormalities occur in ~50% of MDS patients and an interstitial deletion or loss of chromosome 5 containing HSPA9 is the most common, occurring in up to 25% of …

    wustl Repository record

  14. Clinical Applicability of Proposed Algorithm For Identifying Individuals At Risk For Hereditary Hematologic Malignancies

    Clifford, Maggie, <p>0000-0003-1993-3321</p>2018

    … to hematologic malignancies. These syndromes are characterized by an increased risk to develop myelodysplastic syndrome (MDS), acute myeloid leukemia (AML), or aplastic anemia (AA) at young ages, with various phenotypic features including peripheral cytopenias, immune dysfunction and …

    uthsc Repository record

  15. INTEGRATED TRANSCRIPTOMIC AND TRANSLATIONAL PROFILING OF EIF6-SBDS IN SHWACHMAN-DIAMOND SYNDROM REVEALS DIFFERENT CELLULAR STATES SHAPED BY RIBOSOME COMPOSITION AND FIDELITY

    D'ANDREA, GIACOMOUniversità degli Studi di Milano2026

    … and lead to human disease. Shwachman–Diamond syndrome (SDS) exemplifies this class of disorders. Caused by biallelic loss-of-function mutations in SBDS, SDS is characterised by exocrine pancreatic dysfunction, growth impairment, bone-marrow failure, and a markedly increased risk of …

    milano Repository record

  16. Purging e alte dosi di chemioterapia con reinfusione di cellule staminali autologhe in linfomi non Hodgkin follicolari resistenti/refrattari

    Bassi, Simona <1973>Alma Mater Studiorum - Università di Bologna2008

    … or unpurged SC. One patient in CR presented myelodysplastic syndrome at 18 months from ASCT. After ASCT 22 pts were in CR, 2 in PR and one patient were not valuable, because died before response assessment. Nine pts in CR showed PD at a median time of 14 months from ASCT. With a median follow …

    bologna Repository record

  17. Characterization of 5-methylcytosine dioxygenase Tet2 and rescue of mutant Tet2 activity by using turbo co-substrate

    Bhattacharya, ChayanUniversity of Missouri--Kansas City2023

    … (TSG). One such epigenetic mechanism observed in myelodysplastic syndrome (MDS) is the acquired progressive methylation of CpG islands in gene promoters, leading to transcriptional repression. The TET family of hydroxylases/dioxygenases, which includes TET1-3, has recently been identified as iron …

    umkc Repository record

  18. Computational analyses of blood cells: somatic evolution and morphology

    Almeida, JoséUniversity of Cambridge2022

    … that can progress to blood cancers such as myelodysplastic syndromes, characterized by an excess of abnormally developed (or dysplastic) cells in the bone marrow and in the blood. Blood cancers such as these are usually diagnosed by trained experts using a number of complementary analyses, …

    cambridge Repository record

  19. Deciphering the Mechanisms of Heterogeneity within Haematopoiesis in Health, Development & Disease

    Chabra, ShiromUniversity of Cambridge2024

    … in SF3B1-mutant erythroid cells – a common myelodysplastic syndrome (MDS) mutation in a component of the spliceosome. Understanding the intricacies of haematopoietic heterogeneity is crucial, given its implications for various diseases and its relevance to advancements in stem cell …

    cambridge Repository record

  20. Separation and Further Characterization of Hematopoietic Cell Populations Based on Phenotypic and Biophysical Properties

    Dykes, JosefinaDivision of Hematology and Transfusion Medicine, Department of Laboratory Medicine, Lund University2013

    … recipient-derived RBC in a patient with relapsed myelodysplastic syndrome (MDS) following allogeneic HSCT. The presence of the original cytogenetic 20q-deletion in myeloid cell populations of different maturity, suggested an origin common to the original myeloid malignant clone and the reappearing …

    lund Repository record

Page 1 of 2