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Showing 1 to 1 of 1 for “"Myeloablative stress"”.
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Role of S6K1 in regulating self-renewal of hematopoietic stem cells and propagatoin of leukemia
… of S6K1, mice are more susceptible to repeated myeloablative stress. We also observed that loss of expression as well as gain of expression of S6K1 affects the self-renewal ability of HSCs. Interestingly, when we overexpressed S6K1, it also resulted in reduced self-renewal of HSCs. Next, we …