Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 45 for “"Myelin Sheath"”.
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Polarization Controlled Coherent Anti-Stokes Raman Scattering Microscopy for Determination of Structural Order of the Myelin Sheath
… a strong label-free signal in lipid. The myelin sheath surrounding nerves is up to 80% lipid, and therefore is an ideal candidate for CARS imaging. The long lipid chains forming the myelin wraps have a directional preference when the myelin is healthy, with CH2 bonds aligned parallel to …
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Conductive PEDOT:PSS fibres for modelling and assessing oligodendrocyte ensheathment
… are recognised for their capacity to ensheath neuronal axons with tightly packed, multi-layered cell membranes, forming the myelin sheath. This myelin sheath plays a pivotal role as an insulating layer surrounding neuronal axons. It effectively segregates the conductive environments …
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Modelling white matter pathology and establishing a novel ex-vivo platform for drug identification in neuroinflammation
… component of the CNS, composed primarily of myelinated axons. Herein, axons and the myelin sheath form a dynamic and communicative axo-glial unit which acts to regulate and support axonal function. The myelin sheath not only electrically insulates axons allowing for rapid and efficient axonal …
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Die Wechselbeziehungen zwischen der Myelinbildung und dem Phänotyp der Axone im Zentralen und im Peripheren Nervensystem der Säugetiere
… interrelationship between axonal diameter and myelin sheath thickness.
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Investigating the assembly of axonal domains for saltatory conduction
… initial segment (AIS) and nodes of Ranvier in myelinated fibres are essential in promoting nerve impulse conduction in the vertebrate central and peripheral nervous system (CNS and PNS). We still do not fully understand what determines exclusive axonal selection by myelin-forming glia, nor do …
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Investigating endothelin receptor B signalling during myelination
… the formation of multi‐layered membranous myelin sheaths around axons. Myelin sheaths, made by specialised glial cells called oligodendrocytes in the central nervous system (CNS), metabolically support underlying axons and speed up electrical impulse conduction, aiding efficient …
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Developing Sphingosine-1-Phosphate (Spns2) Inhibitors for the Treatment of Multiple Sclerosis
… their immune system becomes sensitized to the myelin sheath that covers their neurons in the central nervous system. This results in the degradation of the myelin sheath and irreversible degradation of the nerve cell axons. This damage leads to the development of several neurological …
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Focal adhesion kinase, a major regulator of oligodendrocyte morphological maturation and myelination
The formation of the myelin sheath is a crucial step during development because it enables fast and efficient propagation of signals within the limited space of the mammalian central nervous system. During the process of myelination, oligodendrocytes actively interact with the extracellular matrix …
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Steroid Hormone and Growth Factor Regulation of Peripheral Myelination
… growth factor (PDGF)-A in peripheral myelination was investigated. Lower levels of P0 were found in the developing sciatic nerve of PDGF-A null transgenic mice, especially when active myelin synthesis occurs. Morphological deformities of the myelin sheath were also observed in the …
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Response of stretch-injured schwann cells
Axon fibers are covered by myelin sheath. After axonal damage, demyelination follows with the production of debris. In the Central Nervous System many studies have been performed to observe and analyze stretch injured axons, but very little has been done to study the white matter axonal tracts, …
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Ultrastructural damages in the brain induced by low-intensity primary blast wave : a transmission electron microscopy study on mild traumatic brain injury
… post injury). We observed and quantified myelin sheath defects, microtubule disruptions, mitochondrial abnormalities at 7 and 30 DPI. Additionally, we found quantitative changes in the asymmetric synapses in the different brain sub-regions. These observations unveiled unique …
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Μελέτη της συναπτογενέσεως του ακουστικού φλοιού in vitro άνευ και κατόπιν ηλεκτρικού ερεθισμού ανάλογου προς τα ηλεκτρικά δυναμικά ενέργειας του κοχλιακού νεύρου
… to a continuous sound demonstrated an increased myelinogenesis. Some atypical myelin sheath figures were also seen, such as common myelin sheath around two or three axons, myelination around cell bodies, abnormalities of the internal mesaxon, dilatation of the Smidt-Landermann incisures and …
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Third Harmonic Generation: A Method for Visualizing Myelin in the Murine Cerebral Cortex
… Generation (THG) for the label-free imaging of myelinated axons in the murine cerebral cortex. Myelin plays an important role in the processes of learning and disease. However, much of the myelin biology research thus far has focused on white matter tracts where myelin is more visible. Much is …
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Generation and analysis of transgenic mice expressing ovalbumin as a neo-self antigen under control of the myelin basic protein promoter
… nervous system (PNS) were to be generated. The myelin basic protein (MBP) is a major component of the myelin sheath both within the CNS and the PNS. Therefore the MBP promoter was employed for its distinct regulatory elements to facilitate exclusive CNS or PNS OVA expression. The adoptive …
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Biosynthesis and Signaling of Glucocorticoids and Progestins and Their Effects on Myelin Synthesis in Schwann Cell/neuronal Co-Cultures
The myelin sheath is a specialized membrane in the nervous system that facilitates the transmission of nerve impulses in a fast and efficient manner. Steroids hormones can be synthesized de novo in the nervous system. The major objective of this research was to identify the steroid signal …
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MR Susceptibility Mapping: Improved Quantification and Applications in Developmental Brain Imaging
… of the human brain are primarily composed of myelinated axons, which connect different brain regions, transmit neural signals, and form efficient communication pathways that shape the neural systems responsible for higher-order functioning. The fatty myelin sheath protects and insulates the …
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Vitamin D Inhibits Expression of Protein Arginine Deiminase 2 and 4 in Experimental Autoimmune Encephalomoyelitis Model Of Multiple Sclerosis
… disease is characterized by degradation of the myelin sheath that insulates neurons of the central nervous system manifesting as a heterogeneous collection of symptoms. Two enzymes, protein arginine deaminases type 2 and 4 (PAD2 and PAD4) have been implicated to play an etiologic role in …
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The Origin of Multiple Sclerosis Revisited: The Case for a Soluble Toxin
… exacerbations, the blood-brain barrier and the myelin sheath. Using a Western blot seroreactivity assay, I have identified a 10-fold increase in anti-ETX seroreactivity when comparing MS patient samples to that of controls. Furthermore, PCR analysis of bacterial cultures from patient stool …
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Implementation of nano-liquid chromatography hyphenated to tandem mass spectrometry for protein identification in gel and non-gel based proteomics
… profiling of the proteins present in the murine myelin sheath (Chapter VIII).
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Development of Novel Small-Molecule Therapeutics for Multiple Sclerosis
… overactive enzymes convert peptidyl arginine on myelin structural proteins to neutral citrulline variants. Hypercitrullination disrupts key ionic interactions between myelin proteins and lipid bilayers that are necessary to maintain compaction within the multi-layered myelin sheath. Thus, myelin …
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