Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"Myelin Oligodendrocyte Glycoprotein (MOG)"”.
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Aspects of the Immunobiology of Myelin Oligodendrocyte Glycoprotein (MOG)-induced Experimental Autoimmune Encephalomyelitis (EAE)
This study investigated the immunobiology of MOG-induced EAE in the DA rat, an animal model, which reproduces the immunopathology of the type II MS lesion (Lucchinetti et al., 2000). A newly established immunisation protocol results in a highly synchronised biphasic form of EAE, which mimics the …
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Vaccination with DNA encoding a myelin autoantigen exacerbates experimental autoimmune encephalitis
… of vaccination with a DNA construct encoding the myelin oligodendrocyte glycoprotein (MOG), an important candidate autoantigen in multiple sclerosis, to induce tolerance and protect against experimental autoimmune encephalomyelitis (EAE) was assessed. Unexpectedly, mice vaccinated with MOG-DNA …
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Immunologische Kreuzreaktivität zwischen dem Myelin-Oligodendrozyten-Glykoprotein (MOG) und Butyrophilin (BTN) bei Multipler Sklerose
… factors that disrupt self-tolerance to myelin autoantigens but their identity and mode of action are unknown. This study reports that the epitope specificity of autoantibodies to the myelin oligodendrocyte glycoprotein (MOG), an important candidate autoantigen in MS, is heterogeneous and …
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The Role of Therapy-Induced CD8+ T Cells in a Mouse Model of Multiple Sclerosis
… (EAE) is an induced, autoimmune, demyelinating disease model for human multiple sclerosis (MS). Glatiramer acetate (GA) is an approved immunomodulatory therapy for MS that was discovered through studies in EAE. It is thought that the main mode of action of GA is the induction of a …
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Pathogenicity and Protection Mediated by a Single TCRβ in Experimental Autoimmune Encephalomyelitis
… sequencing of the mouse TCRβ repertoire during myelin oligodendrocyte glycoprotein (MOG)-induced experimental autoimmuneencephalomyelitis (EAE) identified a public TCRβ chain, TCRβ1, which was highly shared among individual mice and preferentially deployed during EAE. Retrogenic expression of …
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Novel Immunotherapies and Immunoregulation in a Chronic Inflammatory Disease of the Central Nervous System
… Chronic EAE was induced by immunization with the myelin oligodendrocyte glycoprotein (MOG) 35-55 peptide. MOG-reactive inflammatory CD4+ T cells infiltrate the CNS and, in concert with other mononuclear cells, cause inflammation and progressive paralysis. The focus of the first study was to …
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Intestinal delivery of heterologous peptides with lactobacilli
… by destruction of several brain antigens in myelin. In order to increase the efficiency of oral tolerance induction, lactobacilli were developed as a tool to deliver heterologous protein into the gastrointestinal tract. Lactobacillus spp. are a potential delivery vehicle for oral antigens …
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Antigen-specific depletion of autoreactive B lymphocytes in Multiple Sclerosis
Multiple sclerosis (MS) is an inflammatory demyelinating autoimmune disease of the central nervous system triggered by the body’s own immune system reacting against self-antigens. Autoreactive B and T lymphocytes as well as activated macrophages and the bodies complement system contribute to, and …
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Σχεδιασμός, σύνθεση και αξιολόγηση αναλόγων των ανοσοκυρίαρχων επιτόπων των πρωτεϊνών της μυελίνης που εμπλέκονται στη σκλήρυνση κατά πλάκας
… ανάλογα με βάση τους ανοσοκυρίαρχους επιτόπους MOG35-55 και MBP85-99. Η πρώτη προσέγγιση στοχεύει στην ανάπτυξη ανοχής του ανοσοποιητικού συστήματος μέσω των δενδριτικών κυττάρων, με τη χρήση πεπτιδικών αναλόγων συζευγμένων με τον πολυσακχαρίτη μαννάνη (πολυμανόζη). Τα συντιθέμενα ανάλογα …