Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"Myelin Debris"”.
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Retinoid X Receptor activation reverses age-related deficiencies in myelin debris phagocytosis and CNS remyelination
Remyelination is a regenerative process that occurs through the formation of myelin sheaths by oligodendrocytes, which are recruited as oligodendrocyte progenitor cells (OPCs) after demyelination in diseases such as Multiple Sclerosis (MS).A key environmental factor regulating OPC differentiation …
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Myelination diseases of the central nervous system: Artificial Axons as in vitro models of chemomechanical cues
Myelination is a key biological process wherein glial cells such as oligodendrocytes wrap myelin around neuronal axons, forming an insulative sheath that accelerates signal propagation down the axon. A major obstacle to understanding myelination is the challenge of visualizing and reproducibly …
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Development of Novel Small-Molecule Therapeutics for Multiple Sclerosis
… overactive enzymes convert peptidyl arginine on myelin structural proteins to neutral citrulline variants. Hypercitrullination disrupts key ionic interactions between myelin proteins and lipid bilayers that are necessary to maintain compaction within the multi-layered myelin sheath. Thus, myelin …
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Diffuse Brain Injury Triggers Ultra-Rapid Perisomatic Traumatic Axonal Injury, Wallerian Change, and Non-Specific Inflammatory Responses
… were seen. Later, activated microglia contained myelin debris while only limited microglial aggregations were recognized. Macrophages also localized to injured loci with select cells approximating somata of axotomized neurons. Immune cell observations correlated with altered BBB permeability. …
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LIPID COMPOSITION OF MICROGLIAL CELLS AND EFFECTS OF A REMYELINATION-PROMOTING ANTIBODY ON THE SPHINGOLIPID PATTERNS
… sclerosis (MS) is one of the most prevalent demyelinating diseases among young adults (Lemus et al., 2018). Myelin damage and oligodendrocyte death are caused by the autoimmune attack of T cells that cross the blood-brain barrier resulting in the formation of sclerotic plaques (Pearce, 2005, …
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Oligodendrocytes of the adult median eminence
Oligodendrocytes (OLs) are the myelin forming cells of the CNS. Once thought to be generated exclusively during development, recent advances have shown that new OLs are generated in the adult brain from oligodendrocyte progenitor cells (OPCs) in response to physiologically relevant stimuli such as …
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CNS Remyelination and the Gut Microbiota
Remyelination describes the regeneration of myelin sheaths, and is considered one of the most promising strategies for improving the prognosis of demyelinating diseases such as multiple sclerosis. Data from animal models and human studies have shown that remyelination can occur extensively in the …
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The role of the microglial P2Y₆ receptor in ageing, development, and tauopathy
… deficiency reduced microglial phagocytosis of myelin debris. *In vivo*, P15 *P2ry6⁻´⁻* mice, but not P30 *P2ry6⁻´⁻* mice, were observed to have reduced cortical myelination compared to *P2ry6⁺´⁺*, with no change in the internalisation of a myelin-associated protein within CD68+ lysosomes in …