Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 20 for “"Myelin Basic Protein (MBP)"”.
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Steroid Hormone and Growth Factor Regulation of Peripheral Myelination
… growth factor (PDGF)-A in peripheral myelination was investigated. Lower levels of P0 were found in the developing sciatic nerve of PDGF-A null transgenic mice, especially when active myelin synthesis occurs. Morphological deformities of the myelin sheath were also observed in the …
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Autotaxin: A Regulator of Oligodendrocyte Differentiation
… cells (OPCs) to differentiate into fully mature, myelinating oligodendrocytes, they must be specified at the correct times and undergo coordinated changes in both gene expression and morphology. As oligodendrocytes differentiate, they transition from a bipolar morphology into a morphology …
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Humanized Chimeric Receptors in the Therapy of Multiple Sclerosis
… by linking the 84-102 epitope of human myelin basic protein (MBP) to the extracellular and transmembrane domains of the beta chain of human major histocompatibility complex (MHC) class II molecule and the cytoplasmic zeta chain of T cell receptor and pairing it to the alpha chain linked …
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Generation and analysis of transgenic mice expressing ovalbumin as a neo-self antigen under control of the myelin basic protein promoter
… nervous system (PNS) were to be generated. The myelin basic protein (MBP) is a major component of the myelin sheath both within the CNS and the PNS. Therefore the MBP promoter was employed for its distinct regulatory elements to facilitate exclusive CNS or PNS OVA expression. The adoptive …
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Differential Proteomic Investigations Of Normal Appearing Gray Matter In Multiple Sclerosis And Control Post-Mortem Brain Tissue.
… in the expression of mitochondrial and related proteins, The mitochondrial proteome in motor and parietal cortex has been characterized using Surface-Enhanced Laser Desorption Ionization Time of Flight Mass Spectrometry (SELDI-TOF-MS). Principal component analysis (PCA) and hierarchical …
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Conductive PEDOT:PSS fibres for modelling and assessing oligodendrocyte ensheathment
… multi-layered cell membranes, forming the myelin sheath. This myelin sheath plays a pivotal role as an insulating layer surrounding neuronal axons. It effectively segregates the conductive environments inside and outside neuronal axons, thereby preventing ion leakage and minimising signal …
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Structural basis for escaping negative selection by T cell receptor with high affinity for self antigen
… TCR (MS2-3C8) bound to a self-peptide from myelin basic protein (MBP) and the multiple sclerosis-associated MHC molecule HLA-DR4. MS2-3C8 is encephalitogenic in humanized transgenic mice. The structure showed loose accommodation of MBP in the HLA-DR4 binding groove, accounting for its low …
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Multiple Toll-Like Receptor Agonists Act as Potent Adjuvants in the Induction of Autoimmunity
… Mice developed EAE following immunization with myelin antigen emulsified in IFA with various PAMPs, indicating that various PAMPs can participate as the adjuvant necessary to induce EAE. I also examined the effect of PAMPs on APC activation and found that DCs pulsed with antigen and activated …
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Innervation des Cervidenhodens
… a few cholinergic nerves in the cervine testis. Myelinated fibres occurr in the spermatic cord and the tunica albuginea as shown by Myelin-Basic-Protein (MBP)-immunreaction and are regarded as afferent. The viscerosensory quality in the testicular intrinsic innervation is mediated by Calcitonin …
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OPIOID ADDICTION AND PREGNANCY: POTENTIAL EFFECTS OF SUBSTITUTION THERAPIES ON DEVELOPMENTAL MYELINATION
… induces dose-dependent alterations in rat brain myelination. These time-specific effects suggested that both therapeutic and supra- therapeutic doses of the drug could alter the normal pattern of oligodendrocyte development. In support of this hypothesis, this thesis work has now found that …
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Role of the Neurotransmitter Glutamate in Neural Stem and Progenitor Cells Differentiation into Oligodendrocytes
… of interest which can be used to replace lost myelin in some cases of neurodegenerative diseases such as multiple sclerosis (MS) or insults such as spinal cord injury. I investigated the requirements to drive immature NSPCs into oligodendrocyte precursor cells (OPCs) using various driving …
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The Role of Specific Integrase Strand Transfer Inhibitors (INSTIs) in the Alteration of Oligodendrocyte Maturation and Myelination in Hand
… damage and loss of white matter and myelin. Furthermore, the severity of white matter damage correlates with the length of ART duration. However, almost no studies have been performed to determine how the myelin sheath or the oligodendrocytes that synthesize the sheath are damaged. …
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DEVELOPMENT OF NEW OLIGODENDROCYTE-BASED MODELS TO IDENTIFY PHARMACOLOGICAL AGENTS WITH REMYELINATING ACTIVITY
… system, characterized by neuroinflammation and demyelination. While immunomodulatory disease-modifying drugs offer relief from MS symptoms in its relapsing-remitting forms, they do not support remyelination in the progressive and most severe forms of the disease. This is because, up to date, drugs …
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Protein factors and 5' flanking sequences involved in the expression of the mouse myelin basic protein gene.
Myelin Basic Protein is a major structural protein of vertebrate myelin. The gene that codes for MBP is contained within the golli-MBP complex. This gene complex consists of two overlapping transcription units, golli and MBP, which are regulated by two distinct promoters. The golli unit is …
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The role of citrullination of central nervous system proteins in multiple sclerosis.
… by focal lesions of inflammation and demyelination, with subsequent axonal damage. Although the cause is not yet known, it is thought to be autoimmune in origin. Antibodies are implicated in the disease process, as these are detectable in the cerebrospinal fluid (CSF) seen as oligoclonal …
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Novel mechanism in astrocyte gene regulation and function
… clearly demonstrate that YKL-40 inhibits myelin basic protein (MBP) expression during the in-vitro differentiation of oligodendrocyte progenitor cells into myelin producing oligodendrocytes. Thus, we propose that YKL-40 is produced and secreted by reactive astrocytes during various CNS …
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Neuroprotective effects of the dual glycogen synthase kinase-3b and phosphodiesterase 7 inhibitor VP3.15 and of an enriched environment in germinal matrix-intraventricular hemorrhage
… preserved corpus callosum volume and increased myelin basic protein (MBP) levels. VP3.15 ameliorated neuronal loss and maintained Purkinje cell arborization. In addition, the treatment decreased tau hyperphosphorylation and enhanced proliferation and neurogenesis. VP3.15 also prevented the …
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Functional characterization of Pura in vivo and in vitro - Pura knock-out mice and Pura DNA unwinding activity
Pura is a ubiquitous DNA- and RNA-binding protein that is highly conserved in eukaryotic organisms. Pura binds preferentially to purine-rich single-stranded DNA. To date, biochemical analyses of Pura have indicated that this protein might be involved in diverse cellular functions, including DNA …
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Effects of dietary intervention on inflammation and intrauterine growth restriction in neonatal piglets
… brain derived neurotrophic factor (BDNF), myelin basic protein (MBP), and glutamic acid decarboxylase (GAD1) expression regardless of birth weight. SGA piglets had an increased hippocampal total omega-6 to total omega-3 fatty acid ratio. These data show that SGA piglets had reduced …
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Σχεδιασμός, σύνθεση και αξιολόγηση αναλόγων των ανοσοκυρίαρχων επιτόπων των πρωτεϊνών της μυελίνης που εμπλέκονται στη σκλήρυνση κατά πλάκας
… βάση τους ανοσοκυρίαρχους επιτόπους MOG35-55 και MBP85-99. Η πρώτη προσέγγιση στοχεύει στην ανάπτυξη ανοχής του ανοσοποιητικού συστήματος μέσω των δενδριτικών κυττάρων, με τη χρήση πεπτιδικών αναλόγων συζευγμένων με τον πολυσακχαρίτη μαννάνη (πολυμανόζη). Τα συντιθέμενα ανάλογα χρησιμοποιήθηκαν σε …