Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 34 for “"Myelin Basic Protein"”.
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Development of a Top-Down Proteomics Platform for Characterizing Myelin Basic Protein Proteoforms
… proteomic analysis platform for the analysis of myelin basic protein was designed and applied to murine central nervous system tissue. The compatibility of superficially porous (SP) resin for label-free intact protein analysis of myelin basic protein with on-line capillary liquid chromatography …
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Protein factors and 5' flanking sequences involved in the expression of the mouse myelin basic protein gene.
Myelin Basic Protein is a major structural protein of vertebrate myelin. The gene that codes for MBP is contained within the golli-MBP complex. This gene complex consists of two overlapping transcription units, golli and MBP, which are regulated by two distinct promoters. The golli unit is …
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Generation and analysis of transgenic mice expressing ovalbumin as a neo-self antigen under control of the myelin basic protein promoter
… nervous system (PNS) were to be generated. The myelin basic protein (MBP) is a major component of the myelin sheath both within the CNS and the PNS. Therefore the MBP promoter was employed for its distinct regulatory elements to facilitate exclusive CNS or PNS OVA expression. The adoptive …
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Imaging Myelin Basic Protein expression in a model of remyelination by Magnetic Resonance Imaging using an Organic Anion Transporter Protein gene reporter system.
Demyelination occurs in several CNS diseases. If demyelinated axons are not remyelinated they become vulnerable to irreversible degeneration. There is, therefore, a clinical need for therapies that enhance remyelination. This can be achieved by 1) pharmacologically targeting endogenous …
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Use of Fluorescence to Study the Membrane Binding Domain of Cytochrome B(5) and the Induction of Membrane Domain Formation in Phospholipid Vesicles by Myelin Basic Protein
Embargo set by: Seth Robbins for item 86158 Lift date: Forever Reason: Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs
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Molecular Analysis of Neural Structures During Song Learning in the Zebra Finch
… Here I have identified two neural structural proteins, the medium subunit of neurofilament and myelin basic protein, as being important in the formation and completion of the motor path for song production. Transcripts coding for neurofilament are not developmentally regulated within the song …
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Endogenous Neurosteroid Hormone Production and Early Oligodendricyte Development
… disorder classified by rampant demyelination, exemplifies the neuroendocrine crosstalk facilitated by CNS-resident steroids. Local steroid production from cholesterol, which also happens to be the primary lipid component of myelin sheaths, is critical to myelin repair. Progesterone …
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Steroid Hormone and Growth Factor Regulation of Peripheral Myelination
… growth factor (PDGF)-A in peripheral myelination was investigated. Lower levels of P0 were found in the developing sciatic nerve of PDGF-A null transgenic mice, especially when active myelin synthesis occurs. Morphological deformities of the myelin sheath were also observed in the …
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Autotaxin: A Regulator of Oligodendrocyte Differentiation
… cells (OPCs) to differentiate into fully mature, myelinating oligodendrocytes, they must be specified at the correct times and undergo coordinated changes in both gene expression and morphology. As oligodendrocytes differentiate, they transition from a bipolar morphology into a morphology …
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Humanized Chimeric Receptors in the Therapy of Multiple Sclerosis
… by linking the 84-102 epitope of human myelin basic protein (MBP) to the extracellular and transmembrane domains of the beta chain of human major histocompatibility complex (MHC) class II molecule and the cytoplasmic zeta chain of T cell receptor and pairing it to the alpha chain linked …
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Transgenic complementation of rumpshaker with wild type proteolipid protein
Mutations in the x-linked myelin proteolipid protein 1 gene (PLP1) cause the heterogeneous syndromes of Pelizaeus Merzbacher disease (PMD) and Spastic paraplegia type 2(SPG2) in man (Hudson et al., 2004). A single base change mutation in our spontaneous mouse model rumpshaker (Plpjp-rsh)(Ile186Thr) …
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Differential Proteomic Investigations Of Normal Appearing Gray Matter In Multiple Sclerosis And Control Post-Mortem Brain Tissue.
… in the expression of mitochondrial and related proteins, The mitochondrial proteome in motor and parietal cortex has been characterized using Surface-Enhanced Laser Desorption Ionization Time of Flight Mass Spectrometry (SELDI-TOF-MS). Principal component analysis (PCA) and hierarchical …
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Conductive PEDOT:PSS fibres for modelling and assessing oligodendrocyte ensheathment
… multi-layered cell membranes, forming the myelin sheath. This myelin sheath plays a pivotal role as an insulating layer surrounding neuronal axons. It effectively segregates the conductive environments inside and outside neuronal axons, thereby preventing ion leakage and minimising signal …
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Structural basis for escaping negative selection by T cell receptor with high affinity for self antigen
… TCR (MS2-3C8) bound to a self-peptide from myelin basic protein (MBP) and the multiple sclerosis-associated MHC molecule HLA-DR4. MS2-3C8 is encephalitogenic in humanized transgenic mice. The structure showed loose accommodation of MBP in the HLA-DR4 binding groove, accounting for its low …
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Study of proteins after recovery from bacterial infection
… The objective of this study was to compare the proteins and peptides present in the microglia of BCG-challenged mice one-week after treatment relative to control mice and gain insights through differential detection and enrichment analysis. Detection relied on tandem mass spectrometry …
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Identification and characterization of diatom kinases catalyzing the phosphorylation of biomineral forming proteins
… Long-chain polyamines and highly phosphorylated proteins, silaffins and silacidins, are believed to play an important role in biosilica formation. The phosphate moieties on silaffins and silacidins play a significant role in biomineral formation, yet no kinase has been identified that …
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Der Einfluß eines fötal exprimierten Autoantigens auf die Induktion von Autoimmunität während der Schwangerschaft
… transgene Mäuse entwickelt, die das Autoantigen Myelin Basic Protein 1-10, kovalent gebunden an MHC Klasse II exprimieren. Die Transgene, unter der Kontrolle eines MHC Klasse II Promotors, wurden sowohl von fötalen Zellen, als auch im adulten Tier MHC Klasse II-spezifisch exprimiert. Die …
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Multiple Toll-Like Receptor Agonists Act as Potent Adjuvants in the Induction of Autoimmunity
… Mice developed EAE following immunization with myelin antigen emulsified in IFA with various PAMPs, indicating that various PAMPs can participate as the adjuvant necessary to induce EAE. I also examined the effect of PAMPs on APC activation and found that DCs pulsed with antigen and activated …
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Innervation des Cervidenhodens
… a few cholinergic nerves in the cervine testis. Myelinated fibres occurr in the spermatic cord and the tunica albuginea as shown by Myelin-Basic-Protein (MBP)-immunreaction and are regarded as afferent. The viscerosensory quality in the testicular intrinsic innervation is mediated by Calcitonin …
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Analysis of a bacterial serine/threonine kinase
RdoA is a bacterial protein kinase from Salmonella enterica serovar Typhimurium first noted for its regulation of dsbA expression in this organism. The crystal structure of RdoA’s homologue, YihE from Escherichia coli, revealed a basic bi-lobal kinase domain that is a hallmark of the eukaryotic …
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