Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"Myddosome"”.
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Understanding the Myddosome Complex: An Exploration of How Homotypic Death Domain Interfaces Contribute to Overall Structure.
The Myddosome is a large multimeric complex assembled through homotypic interactions between the Death Domains (DDs) of adjacent proteins. It acts as a scaffold bringing downstream signaling elements into proximity with each other. This allows for the subsequent activation of downstream …
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Development of novel imaging technology to study cell signalling
… ldSPIM to characterize TLR4 activation and Myddosome signalling. The TLR4 agonist lipopolysaccharides (LPS) and aggregates of amyloid-β, which are supposed to be one of the key toxic species in Alzheimer’s disease, were delivered onto single macrophage stably expressing a MyD88-eGFP fusion …
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The role of adaptor protein Mal/TIRAP in transducing TLR signalling
… of the supra molecular organising centre, the myddosome. The precise association of Mal/TIRAP with the TLRs and the myddosome is poorly understood. Understanding the timing and the stoichiometry of Mal/TIRAP in complex with TLR4 and TLR2 and the myddosome is critical to understanding the …
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Investigating TLR-4 signalling in response to protein ligands
… as a bridge for MyD88 which goes on to form the myddosome, a large protein complex of six to eight MyD88 molecules and four Interleukin-1 receptor- associated kinase (IRAK) 4 and four IRAK1/2 molecules. This triggers a signalling cascade which results in nuclear factor (NF)-κB transcription …
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Structure and Function of the Pseudokinases IRAK2 and IRAK3 and their Potential as Drug Targets
… form an oligomeric signalling complex called the Myddosome. Subsequently, IRAK kinases and pseudokinases recruit and activate a number of E3 ubiquitin ligases that trigger downstream signalling events to induce the production of pro- and anti-inflammatory mediators. The emergence of crystal …