Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 12 of 12 for “"Mycolic acids"”.
-
The genetics of mycolic acids biosynthesis in Corynebacterium glutamicum
… cell wall structures, which include corynemycolic acids, act as a physical barrier for DNA transformation into the cell. The research reported in this thesis focuses mainly on understanding the nature of physical barrier including, firstly, determining the effect of growth medium containing …
-
Trehalose Monomycolate Biosynthesis and Utilization in Mycobacterium tuberculosis
… by the presence of long chain, ¿¿-branched mycolic acids. The Antigen 85 (Ag85) family of enzymes catalyze the transfer of mycolic acids from a single donor, trehalose monomycolate (TMM), to different acceptors located within the cell wall. Although there are three different pathways in M. …
-
Genetic engineering of recombinant anti-mycolic acid antibody fragments for use in tuberculosis diagnostics
Mycolic acids are long chain lipids from the cell walls of Mycobacterium tuberculosis. The Nkuku phage display library was previously used to obtain monoclonal antibody binders to mycolic acids. In total 11 binders were obtained of which one was selected (MAC10) for further investigation by genetic …
-
Design, Synthesis, and Evaluation of Novel Antimycobacterial Agents With Enhanced Pharmacokinetic Profiles
… inhibition of bacterial cell wall biosynthesis. Mycolic acids, which are α-alkylated β-hydroxylated fatty acids, are the primary lipid constituents of the mycobacterial cell wall and are synthesized intracellularly in the cytoplasm. Mycobacterial membrane protein large 3 (MmpL3) is an essential …
-
In situ sintering study of model nickel catalysts
… an alternative to cholesterol catabolism, fatty acids like stearic acid are important in producing building blocks for long chain mycolic acids which provides protection to the mycobacterium. For this reason thiastearic acid derivatives were synthesized and evaluated as biomarkers.
-
Synthesis and evaluation of flouro and thia lipids as bioanalytical tools
… an alternative to cholesterol catabolism, fatty acids like stearic acid are important in producing building blocks for long chain mycolic acids which provides protection to the mycobacterium. For this reason thiastearic acid derivatives were synthesized and evaluated as biomarkers.
-
Electrochemical impedance spectroscopy and surface plasmon resonance for diagnostic antibody detection
… this in the case of detection of biomarker anti-mycolic acid antibodies for TB diagnosis has been provided in the Mycolic acid Antibody Real-Time Inhibition assay (MARTI) by our research group. Although already patented and published, MARTI is not yet a feasible diagnostic test due to slow sample …
-
Optimization of N-(1-Adamantyl)-3-Aryl Acetamides as Novel Antimycobacterial Agents
… transmembrane protein responsible for shuttling mycolic acids from the cytosol to the outer membrane of mycobacteria, and its inhibition results in mycobacterial growth inhibition. Previously, urea- and indole-based MmpL3 inhibitors have demonstrated promising antimycobacterial activity with …
-
Barriers to tuberculosis drug discovery: the mycobacterial cell wall
… membrane, including arabinogalactan chains and mycolic acids that are covalently bonded to the peptidoglycan layer, resulting in a highly selectively permeable barrier that is unique to this genus. The current treatment for tuberculosis (TB) utilizes antibiotics that weaken the structural …
-
The Use of Spectroscopic Techniques in the Characterization of Mycobacterial Metabolites
… lipids, the second is for covalently bound mycolic acids and the third deals with the complex cell wall polysaccharides. Key structural features and major lipid species were readily identifiable using this technique. This approach can be used for observing changes in the cell wall due to …
-
Channel-forming proteins in the cell wall of amino acid-producing Corynebacteria
… C. efficiens a member of the diverse group of mycolic-acid containing actinomycetes, the mycolata. These bacteria are potent producer of glutamate, lysine and other amino acids on industrial scale. The cell walls of most actinomycetes contain besides an arabinogalactan-peptidoglycan complex …