Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"Mycolactone"”.
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Understanding buruli ulcer : elucidation of the cellular and molecular mechanisms underlying infection with mycobacterium ulcerans
… the secretion of a lipidic exotoxin known as mycolactone, which is responsible for the induction of cell death and tissue necrosis. All these particular features impact on the mycobacterial nature of this intriguing pathogen. Mycolactone has been attributed cytotoxic and immunosuppressive …
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High Resolution Mass Spectrometry (HRMS) Based Investigation of Small Molecule, Bioactive Secondary Metabolites as Probes in the Examination of Bacterial Resistance and Virulence
<p>The widespread availability of antimicrobial chemotherapeutics over the last half of the twentieth century has offered dramatic increases in life expectancy. Unfortunately, many pathogenic agents are exhibiting ever increasing resistance to many frontline antibiotics. New chemotherapeutic agents …
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The Use of Spectroscopic Techniques in the Characterization of Mycobacterial Metabolites
… better analyzed through an MS-based approach. Mycolactones of <em>M. ulcerans</em> and other closely related species are good examples for such metabolites and in this work we have demonstrated the utility of MS as a tool for screening for mycolactones from both bacterial culture and tissue …