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Showing 1 to 4 of 4 for “"Mycofactocin"”.
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New Insights into Mycofactocin Biosynthesis, Structure and Function
<p>Mycofactocin is a putative ribosomally synthesized and post-translationally modified peptide (RiPP)-derived redox cofactor. Its biosynthesis is accomplished through the dedicated actions of the products of six conserved genes, <em>mftABCDEF</em>. The mycofactocin pathway is one of the most …
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Mechanistic Insights into MftR-Dependent Regulation of the Redox Cofactor Mycofactocin
… quinone, which has been well-characterized, and mycofactocin (MFT), which was recently discovered.</p> <p>While MFT biosynthetic proteins have been extensively characterized, the physiological conditions that require MFT is not well-understood. To gain insights into the regulation of MFT in …
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Sensitivity of Radical SAM Enzyme MftC to Molecular Oxygen
… catalyzes the first step in the production of mycofactocin. It is a ribosomally synthesized post-translationally modified (RiPP) redox cofactor shown to be essential for the survival of bacteria in the <em>Mycobacterium</em> genus in the presence of cholesterol as a carbon source and for the …
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Development Towards an Ethylene Sensing Artificial Metalloenzyme
… protein scaffold are also here reported.</p> <p>Mycofactocin (MFT) is a ribosomally synthesized and post-translationally modified peptide (RiPP) hypothesized to function as a redox cofactor in bacteria, particularly the Mycobacteria genus, which includes M. tuberculosis. In order to further …