Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 403 for “"Mycobacterium tuberculosis"”.
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Mycobacterium tuberculosis metallomics
Tuberculosis (TB) remains a major global health challenge, compounded by the rise of drug-resistant Mycobacterium tuberculosis (Mtb) strains, which necessitate the development of novel therapies or improvement of existing ones. Nanotechnology has gained prominence in the biomedical field, yet its …
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Tenosinovitis infecciosa por Mycobacterium Tuberculosis
… frecuente de manifestación extrapulmonar del Mycobacterium tuberculosis, etiología que por su comportamiento clínico y paraclínico puede confundir al examinador retardando su proceso diagnóstico Este artículo presenta el caso de un paciente masculino de 63 años, diestro, cesante, sin …
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Functional Genome Analysis of Mycobacterium tuberculosis
… DNA-Arrays, die sämtliche offenen Leseraster von Mycobacterium tuberculosis repräsentieren, wurde eine funktionelle Genom-Analyse des Erregers der Tuberkulose durch geführt. Ein Genom-Vergleich von Mitgliedern des M. tuberculosis-Komplexes wies zusätzlich zu den bekannten Deletionen weitere, …
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Improving antibiotic therapy for Mycobacterium tuberculosis
Mycobacterium tuberculosis (Mtb) is a slow-growing bacterium that causes tuberculosis (TB), which is a leading cause of death from an infectious disease worldwide. The emergence of drug-resistant strains has made TB increasingly difficult to treat, especially in individuals with weakened immune …
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The Mycobacterium tuberculosis protein O-phosphorylation landscape
… protein kinases (STPKs) is identified. Mycobacterium tuberculosis (Mtb) in particular has a larger repertoire of both STPKs and O-phosphoproteins than most bacteria, suggesting a more prevalent role of STPKs in Mtb. Many studies have identified individual STPK functions and substrates, …
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Identification of virulence determinants of Mycobacterium tuberculosis via genetic comparisons of a virulent and an attenuated strain of Mycobacterium tuberculosis.
… through the genetic analyses of two strains of Mycobacterium tuberculosis, one virulent, H37Rv, one attenuated, H37Ra. Derived from the same parent, H37, genomic differences between strains were first examined via two-dimensional DNA technologies: two-dimensional bacterial genome display, and …
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Expression and characterisation of metalloproteins from mycobacterium tuberculosis
The resurgence of tuberculosis cases world-wide over the last two decades has led to one third of the population being infected and an ever increasing number of deaths (World Health Organisation, 2006). Little is known about the pathogenicity of the infectious agent, Tubercule bacillus, and …
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The DNA Binding Protein Lsr2 from Mycobacterium tuberculosis
… actinomycetes. Lsr2 is essential for growth in Mycobacterium tuberculosis and previous studies have shown that Lsr2 is involved in down-regulating a wide range of genes involved in cell wall synthesis and metabolic functions. This regulatory function is likely to influence bacterial growth and …
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Mycobacterium tuberculosis Lipids Activate Neurons and Trigger Cough
Pulmonary tuberculosis, a disease caused by Mycobacterium tuberculosis (Mtb), manifests with a persistent cough as both a primary symptom and a transmission mechanism. While nociceptive neurons innervating the lungs trigger the cough reflex and some bacteria produce neuron-targeting molecules, how …
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Immune Modulation of The Mycobacterium Tuberculosis Granulomatous Response
<p> <p>Tuberculosis (TB) remains a major public health burden. The immunocompetant host responds to <em>Mycobacterium tuberculosis</em> (MTB) infection by the formation of granulomas, which initially prevent uncontrolled bacterial proliferation and dissemination. However, increasing evidence …
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Trehalose Monomycolate Biosynthesis and Utilization in Mycobacterium tuberculosis
<p>Treating Mycobacterium tuberculosis (M. tb) infections in the 21st century is an increasingly daunting task, as antibiotic resistance has become more prevalent and treatment accordingly more complex. One property that makes M. tb so difficult to treat is its extremely hydrophobic, highly …
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Identification and characterisation of proteases in Mycobacterium tuberculosis
Virulence determinants of M. tuberculosis remain largely unknown. Of key interest has been the ability of the bacterium to survive intracellularly within its host cell, the macrophage, and its ability to cause extensive tissue necrosis. Exported proteases are commonly associated with virulence in …
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Transcription analysis of virulent strains of Mycobacterium tuberculosis
… of new drugs and success of social programs, tuberculosis remains a leading cause of mortality. This burden falls disproportionately on developing countries where the high burden of HIV has a potentiating e↵ect, but may soon return to areas where it was previously brought under control as …
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Molecular mechanisms of DNA repair in Mycobacterium tuberculosis
… drugs aimed at reducing the capacity of Mycobacterium tuberculosis to adapt genetically during tuberculosis (TB) treatment. The thesis presented here aimed to investigate the contribution of the DNA damage (SOS) response in adaptive mutagenesis, and focused on two specific components: the …
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Identification of the virulence gene of Mycobacterium tuberculosis
… characterize potential virulence genes from M. tuberculosis. To this end, we have compiled and integrated information from various public databases to catalogue 246573 microbial genes from 84 organisms, including pathogens and non pathogenic microbes. We determined the phylogenetic distributions …
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Mycobacterium Tuberculosis Virulence Factor Mpt64 Targets the Endoplasmic Reticulum
Mycobacterium tuberculosis, the causative agent of tuberculosis, is one of the most successful human pathogens. One reason for its success is that M. tuberculosis can reside within host macrophages, a cell type that normally functions to phagocytose and destroy infectious bacteria. However, M. …
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