Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"Mycobacterium marinum"”.
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Infections of Drosophila melanogaster with pathogens: Mycobacterium marinum and Burkholderia thailandensis
… thesis focuses on infection of Drosophila with Mycobacterium marinum. Tuberculosis remains one of the most widespread infectious diseases in the world affecting approximately one third of the world’s population1. The bacterium that causes this serious affliction is Mycobacterium tuberculosis, a …
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Immunologic and Protective Effects of Vaccines for Mycobacterium marinum in Morone sp
Recombinant and DNA vaccines utilizing Mycobacterium sp. antigen 85A (Ag85A) were assessed for immunostimulatory and protective effects against M. marinum. Because of their known susceptibility to piscine mycobacteriosis, Morone sp. were utilized as the models for these studies. The first study …
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Modification of a DNA Vaccine for Oral Administration in Fish for Aquaculture by Using Non-Microbial Nanoparticles
… oral delivery of a DNA vaccine containing Mycobacterium marinum Ag85A plasmid in either chitosan or PLG nanoparticle encapsulation was evaluated. Hybrid striped bass were divided into four experimental groups: IM immunization of the DNA vaccine as a positive control, oral delivery of …
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Zebrafish Mutagenesis Study of Host Determinants of Mycobacterial Infection Outcome
… with N-ethyl-N-nitrosourea were infected with Mycobacterium marinum and monitored over time. Larvae with increased susceptibility to infection were identified by the presence of mycobacterial cording, a phenotypic proxy for failure of immunity. 279 unrelated families have so far been screened …
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Cell Wall Lipids Promoting Host Angiogenesis During Mycobacterial Infection
… that promote granuloma vascularization. Using Mycobacterium marinum transposon mutants in a zebrafish infection model, we revealed the enzyme Proximal Cyclopropane Synthase of alpha-Mycolates (PcaA) as an important bacterial determinant of host angiogenesis. We found that PcaA-modified …
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Identifying biosynthetic pathways for mycobacterial cell wall components using transposon mutagenesis
Mycobacterium tuberculosis, the causative agent of the infectious disease tuberculosis, has a distinct lipid-rich cell wall. Several anti-TB drugs target cell wall biosynthetic pathways. A good understanding of its biosynthesis will provide helpful clues for the development of novel drug targets. A …
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Lack of Delayed-Type Hypersensitivity in Striped Bass (<i>Morone saxatilis</i>)
… caused by acid-fast bacteria in the genus <em>Mycobacterium</em>. This disease impacts aquaculture, aquariums, and wild fishes. Unfortunately, there are currently no non-lethal diagnostic tests for mycobacterial infection in fishes. Type IV delayed type hypersensitivity (DTH) responses <em>in …
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Metabolomics as a tool in the identification and production of new marine-derived antibiotics from sponges and endosymbiotic bacteria
… Trypanosoma brucei and moderately active against Mycobacterium marinum were isolated from the Irish Sea sponge Haliclona simulans. Extracts from SM8, the Streptomyces sp. isolated from H. simulans demonstrated antibacterial and antifungal activities. NMR spectroscopy identified the major …
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Utilising zebrafish as a model to investigate lymphangiogenesis and its contributions to disease
… vegfc, and vegfd. Finally, it was shown that Mycobacterium marinum-induced granulomas in larval zebrafish, an established model for tuberculosis, induce ectopic lymphatic vessels to form from the existing trunk lymphatic vasculature. This is the first description of lymphangiogenesis …
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A study of the biological activity of bee venom and its fractions with regard to cosmetic science and immunology
… activities against a range of microbes (Mycobacterium marinum, Norcardia farcinia and Trypanosoma brucei brucei) and human cell lines [NCTC2544 (normal keratinocytes), PNT2A (normal epithelial cells), and HS27 (normal fibroblasts)] respectively. Immunomodulatory effects were investigated …
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Characterisation of bedaquiline resistance mediated by the <i>M. tuberculosis</i> MmpS5L5 efflux pump
… to test the function of the MmpS5L5 complex in Mycobacterium marinum and Mycobacterium tuberculosis. Using this system, I show that MmpS5L5 is a multidrug efflux pump able to transport bedaquiline, clofazimine, PBTZ-169, TBAJ-587 and OPC-167832. This system is used to test key aspects of the …
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Functional Characterisation of the Mycobacterial Virulence Protein Erp
Mycobacterium tuberculosis, the causative agent of tuberculosis, is among the most successful human pathogens. Throughout their complex life cycle in the host – infection, growth, transmission – mycobacteria must continually resist host defences. A major mycobacterial survival mechanism lies in the …
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Synthesis, Characterization, and Micellar Properties of Dendritic Amphiphiles
… 3CUr18 and 3CAm19 proved most effective against Mycobacterium smegmatis, with MIC99 = 6.3 μM @ 10⁵ CFU/mL inoculum density. 3CCb20 was most effective against Mycobacterium marinum with MIC99 = 16 μM @ 10⁵ CFU/mL inoculum density. 3CAm19, 3CCb18, and 3CUr18 all showed equivalent activity against …