Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"Mycobacterium leprae"”.
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Defining interactions between Mycobacterium leprae and Langerhans cells
… of the disease date back to at least 600 BC. Mycobacterium leprae, the causative agent of leprosy was first discovered by Dr. Gerhard Armauer Hansen in 1873. Leprosy remains a major health problem in several low- and middle-income countries including Brazil, India, and Indonesia. There are …
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Role of host chromatin remodelling in Mycobacterium leprae-induced Schwann cell fate change
BACKGROUND: Mycobacterium leprae is a strictly obligate, intracellular bacterium that is a causative agent of the chronic infectious disease Leprosy. In humans, M. leprae infects Schwann cells, a type of glial cell that surrounds neurons and is responsible for the formation of the myelin sheath …
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An improved in vitro model for the study of Mycobacterium leprae/Schwann cell interactions
… or other disabilities as a consequence of Mycobacterium leprae infection. Schwann cells, the neural target of M. leprae, have a central role in leprosy histopathology including axonotrophy, altered myelin architecture and demyelination. The mechanisms of nerve damage have not been fully …
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Characterization of protein secretion in Mycobacterium leprae using phoA fusions in Escherichia coli and Mycobacterium smegmatis
Complete sequencing and annotation of the M. leprae genome has provided new information related to proteins constituting its hypothetical proteome. Since M. leprae can not be grown in vitro, novel approaches are needed to determine which proteins are expressed during infection and whether these …
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Struggling against leprosy: physicians, medicine, and society in Colombia, 1880-1940
… Hansen postulated what later came to be known as Mycobacterium leprae as the causative agent of leprosy. In 1897, the first international conference on leprosy declared leprosy a disease produced by Hansen’s bacillus. Meanwhile, Westerners discovered leprosy in their colonial territories during …
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Percepção de profissionais de Unidades Básicas de Saúde mageenses frente à hanseníase: a elaboração de um atlas em Dermatologia
… a pele e os nervos periféricos e é causada pelo Mycobacterium Leprae. No entanto, alterações sensitivas, incapacidades físicas e sequelas irreparáveis decorrem da ausência de um diagnóstico precoce, o que impulsiona nas pessoas dificuldades relacionadas à adaptação à sua condição clínica e na …
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Characterisation of the cold-shock response in Mycobacterium smegmatis
The response of Mycobacterium smegmatis to a cold shock was investigated in order to gain insight into the stress responses of members of the genus Mycobacterium. Mycobacterium smegmatis cultures were shocked from 37°C to 30°C, 25°C, 15°C, and 10°C and the effects on both growth (ATP concentration, …
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Estudo epidemiológico do grau de incapacidade física da hanseníase numa séria histórica de 2010 a 2022 no sul da Bahia
A chronic infectious disease, leprosy has Mycobacterium leprae (M. leprae) as its etiological agent. It is transmitted through the upper airways of people infected with the multibacillary form, without treatment, which release droplets of the bacillus. M. leprae has a tropism for skin cells and …
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Missionaries, the state of leprosy in Zambia
The main purpose of the study was to present a history of leprosy in pre and colonial Zambia (1893 – 1964). Leprosy was a widespread disease whose victims were highly stigmatised, socially discriminated against and isolated. The study focused on approaches by missionaries and government towards its …
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Missionaries, the state of leprosy in Zambia
The main purpose of the study was to present a history of leprosy in pre and colonial Zambia (1893 – 1964). Leprosy was a widespread disease whose victims were highly stigmatised, socially discriminated against and isolated. The study focused on approaches by missionaries and government towards its …
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TLR1 I602S: trafficking dynamics and roles in resistance to mycobacterial infection
… diseases caused by the intracellular pathogens Mycobacterium leprae and Mycobacterium tuberculosis, respectively. This dissertation describes our investigation of the TLR1 I602S polymorphism in the context of receptor trafficking and host defense against mycobacterial infection. My thesis …