Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 31 for “"Mycobacterium bovis"”.
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Population genetic frameworks and functional genomics of Mycobacterium bovis
… is a zoonotic infection of cattle caused by Mycobacterium bovis. Approximately one-third of the world's population is infected with M. tuberculosis or M. bovis, "the world's most successful pathogen", the majority in developing countries. The global spread and increasing severity of …
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Cattle and badger dynamics in relation to the potential transmission of Mycobacterium bovis
The transmission of Mycobacterium bovis between and among cattle and badgers represents an area of research which continues to pose many questions in the pursuit to eradicate the disease from cattle herds within the UK and Ireland. Predominant queries remain over when and where both species become …
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Evaluation of Different Methods for the Detection of Mycobacterium bovis in Lymph Node Tissue
… (LN) tissues. A limit of detection study for Mycobacterium bovis, spiked into negative LN tissue, showed that both liquid culture systems supported growth down to a concentration of 2.5 x 102 cfu/ml. A total of 867 routine LN tissues mainly from bovines but including some badger, deer and …
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Physicochemical and immunological studies of thermally induced conformational changes in protein antigens of mycobacterium bovis strain, BCG
… a typical mycobacterin, the culture filtrate of Mycobacterium bovis, strain BCG 172, during heating and cooling have been investigated and related to the more obvious manifestations of thermal denaturation which have been reported from studies of heated mycobacterins.
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The impact of malaria on the immunogenicity and efficacy of mycobacterium bovis BCG vaccination against mycobacterium tuberculosis in mice
… pathogens that overlap geographically with Mycobacterium tuberculosis (M. tuberculosis). In this study, we used a murine model to investigate the effect of Plasmodium species virulence and the timing of infection on BCG-induced immune responses and efficacy against M. tuberculosis both in …
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Evaluation of granulysin and perforin as candidate biomarkers for protection following vaccination with Mycobacterium bovis BCG or M. bovis DeltaRD1
… perforin, IFNgamma and Fas-L responses to Mycobacterium bovis purified protein derivative (PPD) stimulation by peripheral blood mononuclear cells from M. bovis DeltaRD1-, BCG- and non-vaccinated cattle. Gene expression profiles following PPD stimulation showed significant increases in …
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Cellular immunity of naïve and BCG vaccinated neonates
Despite more than 95% vaccination coverage with Mycobacterium bovis Bacille Calmette-Guérin (BCG), tuberculosis (TB) remains epidemic in South Africa. The dichotomy that successful pregnancy is usually associated with a type 2 (Th2) cytokine profile in the newborn child, whereas immunity to …
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Proteomics of physiologically relevant stresses on model mycobacterium tuberculosis organisms, and the effects on virulence
… and it is estimated that 1.5 million died. Mycobacterium tuberculosis which is the causative agent of tuberculosis disease, is an obligate aerobic bacterium with a unique cell wall and is capable of surviving and infecting a immunocompetent host. The bacteria are spread by aerosols, where an …
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Influence of the potency of antigen presentation on CD8+ T cell differentiation and memory
… (OVA) expressing intracellular bacteria, Mycobacterium bovis (BCG) which induces muted T cell activation, and Listeria monocytogenes (LM) which induces massive T cell activation, the influence of T cell stimulation on memory development was discerned. It was hypothesized that muted …
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Applying Theory To Management: Assessing the Practicality of Leopold's Land Ethic and the Risk Information and Processing (RISP) Model for Wildlife Management
… deer hunters after bovine tuberculosis (Mycobacterium bovis) was detected in the local whitetail deer population, and (2) farmers' attitudes towards and motivations for participation in federal conservation programs beneficial to wildlife. The first of these projects found that attitudes …
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Construction and evaluation of three candidate vaccines expressing HIV-1 subtype-C mosaic Gag
… auxotroph of the tuberculosis vaccine Mycobacterium bovis Bacille Calmette Guérin (BCG). The second was a DNA vaccine vector with enhanced expression of transgenes due to a novel enhancer element from porcine circovirus type 1, which has been demonstrated to increase gene expression. …
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Characterisation of the T cell responses induced by BCG in infants over the first year of life
Mycobacterium bovis Bacille Calmette Guerin (BCG) is the only licensed tuberculosis (TB) vaccine. Despite the immunisation of 3 billion individuals with this vaccine, TB remains a major cause of mortality worldwide. Therefore, there is an urgent need for more effective TB vaccines. BCG is likely to …
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Rapid, Quantitative Assessment of Antimycobacterial Water Disinfection based on the Firefly Luciferase Reporter Gene
Mycobacterium avium causes disseminated infection in humans with immunodeficiency, pulmonary infections in individuals with predisposing lung conditions (e.g., pneumoconiosis), and cervical lymphadenitis in children. Twenty-five to fifty percent of late stage AIDS patients are infected with M. …
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Common Pool Goods and New Technology Adoption: How Canada Can Implement New Vaccinology Strategies Related to Johne’s Disease
… for tuberculosis (TB), caused by the pathogens Mycobacterium tuberculosis (M. tb, the human variant) and Mycobacterium bovis (M. bovis, the bovine variant). When positive TB results are triggered, either due to the presence of the disease or due to false-positives, governments quarantine the …
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Nucleic acid modifications in bacterial pathogens - impact on pathogenesis, diagnosis, and therapy
… facilities. We showed that infection with Mycobacterium bovis bacille Calmette-Guérin produces a granulomatous lung disease in rats that recapitulates many of the important pathological features of human tuberculosis. This model also allowed us to test the utility of nucleic acid …
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Epidémiologie de la brucellose et de la tuberculose animales dans les milieux urbain, périurbain et rural au Niger
… originale à la connaissance des souches de Mycobacterium bovis et de Brucella circulantes au Niger, des mécanismes et facteurs de risque de transmission de ces deux zoonoses majeures dans un contexte d’élevage urbain, périurbain et rural. Matériel et méthodes : Pour caractériser les systèmes …
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Contributions to the mathematical theory of epidemic dynamics
… possible outcomes of a bovine tuberculosis (Mycobacterium bovis) epidemic in a white-tailed deer (Odocoileits virgmiamis) population using data from a recent epidemic in Michigan. I conclude that the best use of epidemic forecasting exercises is to identify critical gaps in knowledge for …
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Immunologic and Protective Effects of Vaccines for Mycobacterium marinum in Morone sp
Recombinant and DNA vaccines utilizing Mycobacterium sp. antigen 85A (Ag85A) were assessed for immunostimulatory and protective effects against M. marinum. Because of their known susceptibility to piscine mycobacteriosis, Morone sp. were utilized as the models for these studies. The first study …
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Chaetophractus villosus reservorio y/o transmisor de algunas enfermedades infecto-contagiosas y/o zoonóticas que afectan a los rumiantes y al hombre
… Chaetophractus villosus estuvieron expuestos a Mycobacterium bovis, el 32% a Neospora caninum, el 12% a Echinococcus granulosus y el 16% a Brucella aislándose Brucella suis biovar 1. Por otra parte, se registró la presencia de anticuerpos contra Mycobacterium avium subsp. paratuberculosis en el …
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Questionnaire-based study to determine the state of tuberculosis testing in goats in South Africa
… though they are known to be susceptible to Mycobacterium bovis. Thus, there was an opportunity to gather information from state veterinarians on their observations of bTB in goats. This information would assist to make a decision on whether to pursue further studies on bTB in goats in South …
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