Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 323 for “"Myc"”.
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Myc-Funktion im Zellwachstum und Identifikation von neuen Myc-regulierten Genen in B-Zellen
Die Überproduktion des Myc-Proteins ist eine Ursache für die Entstehung einer großen Anzahl von humanen Tumoren. Die Erforschung der Myc-Funktionen ist daher ein wichtiges Ziel der Tumorbiologie. Mit einem neuartigen Zellsystem wurde in dieser Arbeit die Rolle von Myc für das Wachstum von Zellen …
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MYC-DEPENDENT TRANSCRIPTIONAL CONTROL IN HUMAN LYMPHOMA
… expression of the oncogenic transcription factor MYC is a widespread feature in cancer and is required for tumor maintenance. Despite substantial research efforts, major gaps persist in our understanding of primary MYC-dependent events in tumors. To address this issue, we inserted an in-frame …
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Selective targeting of MYC by antisense oligonucleotides
MYC is one of the most commonly dysregulated genes across all cancers. As a master transcription factor with greater than 10,000 binding sites throughout the genome, the MYC oncoprotein coordinates a transcriptional regulatory network consisting of approximately 15% of all genes, controlling cancer …
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Chromatin Regulators of MYC Oncoprotein Activity in Cancer
The MYC oncoprotein is a key contributor to the development of virtually all cancer types. MYC is known as a global regulator of transcription that controls diverse physiological and oncogenic functions. Though there are 35 yearsâ worth of research on this protein, mechanistic understanding and …
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Targeting the N-myc oncoprotein using nanobody technology
The myc family of oncogenic transcription factors, which includes c-myc, N-myc and L-myc, control major cellular processes such as proliferation and differentiation by integrating upstream signals and orchestrating global gene transcription. They do this largely through dimerising with Max, which …
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Myc influences glutamine metabolism to induce autophagy in tumorigenesis
… One of the major players in this process is Myc, which can promote tumorigenesis by triggering a metabolic reprogramming that allows cells to produce macromolecules, by modulating glycolytic flux, glutaminolysis, lipidogenesis, and autophagy. The process by which hyperproliferative cells …
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Regulation von Teilungswahrscheinlichkeit und Zellzyklusdauer durch das Onkoprotein c-Myc
… die Rolle des onkogenen Transkriptionsfaktors c-Myc für eine schnelle Zellzyklusprogression untersucht. Der Stand der Forschung zu Beginn der Arbeit legte nahe, dass ohne die Expression von c-Myc eine Zelle nur verzögert den Teilungszyklus durchlaufen kann (Mateyak et al., 1997). Mit Hilfe eines …
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Gcn5 Loss Impacts Myc-Driven Cancer In Mice and Human Cells
… to chromatin by transcription factors such as MYC and E2F1 where GCN5 acetylates H3K9 leading to a more open and accessible chromatin structure. Previous research has demonstrated that GCN5 also acetylates MYC, a protein that amplifies the expression of cancer-promoting genes and is frequently …
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The novel long noncoding RNA lncUSMycN in N-Myc-induced oncogenesis
… of a 130 kb genomic DNA region containing the MYCN oncogene. While MYCN has been extensively investigated, it is unknown whether other genomic elements within the 130 kb amplicon play a role in neuroblastoma. In this study, I experimentally validated the novel long noncoding RNA up-stream of …
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Role of AID and microRNA-155 in c-myc-IgH Translocations
… SHM. To determine whether SHM might induce c-myc to Ig V-JH translocations, we searched for such events in both IL6 transgenic (IL6 tg) and AID-/- IL6 tg mice. Our experiments demonstrate that AID is required for c-myc to Ig V-JH translocations induced by IL6. We also investigated the …
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Investigating the role of mRNA capping enzyme in C-MYC function
C-MYC is a transcription factor and a potent driver of many human cancers. In addition to regulating transcription, C-MYC promotes formation of the mRNA cap which is important for transcript maturation and translation. However, the mechanistic details of C-MYC-dependent mRNA capping are not fully …
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MYC transcriptional functions controlling epidermal stem cell self-renewal and differentiation
The oncoprotein MYC has long been recognized as an important stem cell regulator, yet its direct biological contributions have been difficult to determine. MYC activation can induce pleiotropic phenotypes and mediates cellular functions as opposing as cell growth and proliferation, metabolism, …
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The c-Myc/TBX3/nucleolin/Hsc70 signalling axis in breast cancer
… oncogenic transcription factor c-Myc has been widely reported in breast cancer progression and c-Myc-driven pathways are elevated in aggressive drug resistant breast cancer cells and tumours. Our laboratory has previously shown that c-Myc directly binds and activates the TBX3 …
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INTERACTION OF PTEN DELETION AND C-MYC GAIN IN PROSTATE CANCER PROGRESSION
Prostate cancer is of significant public health importance since it is the most common non-cutaneous cancer and the second leading cause of cancer death among men in the United States. While the majority of prostate cancer patients will not die of the disease and some may not even need treatment, …
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DISSECTING THE ROLE OF Β-CATENIN AND MYC IN GASTRIC TUMOR FORMATION
… in the gastric epithelium and cooperates with MYC in driving gastric tumorigenesis. By integrating transcriptomic and epigenomic analysis with organoid models, we provide phenotypic and mechanistic insights about how MYC and β-catenin integrate their activities in regulating stem cell function …
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The Role of CDCA7 in Akt-mediated Myc-Dependent Apoptosis and Proliferation
… 2001 by Prescott and colleagues as a target of Myc-dependent transcriptional regulation (Prescott et al., 2001). We have identified CDCA7 as associating with the transcription factor Myc and is the target of phosphorylation by the prosurvival serine/threonine kinase Akt. Phosphorylation by Akt …
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Pharmacological regulation of c-myc gene expression in human breast cancer cells
… was to understand the molecular mechanisms of c-myc gene regulation by quinidine. C-myc is one of the most common oncogene aberrations in breast cancers (Deming, S. L. et al., 2000). C-myc functions include regulation of cell cycle, proliferation, differentiation, and apoptosis. The results of …
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