Global ETD Search
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Showing 1 to 2 of 2 for “"Myb domain"”.
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Characterization of DNA Binding Activities at Vertebrate Telomeres
… factors, TRF1 and TRF2, which both contain one Myb-type repeat. We have conducted a detailed analysis of the DNA binding mode of TRF1 and shown that it binds DNA as a dimer by contacting a bipartite DNA site with each Myb domain. The relative orientation and spacing of the two sites does not …
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Mechanistic Understanding of the Role of TRF1 in Telomere Replication
… functional modules in TRF1, one in the TRFH domain and the other one, surprisingly, in the Myb domain. Mutating each module leads to extensive telomere fragility and telomere replication stress. Interestingly, the general transcription factor IIH (TFIIH) complex is also important for …