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Showing 1 to 18 of 18 for “"Myasthenia gravis (MG)"”.
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Neuropsychiatric symptoms in thymoma-associated and non-thymoma myasthenia gravis
Myasthenia gravis (MG) is an acetylcholine receptor antibody- mediated disease targeting the neuromuscular junction resulting in fatigable muscle weakness. A number of reports have suggested a high prevalence of psychiatric symptoms amongst MG patients. Approximately 10% of MG subjects are found to …
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ΜΕΛΕΤΗ ΤΗΣ ΒΑΡΕΙΑΣ ΜΥΑΣΘΕΝΕΙΑΣ ΚΑΙ ΤΟΥ ΥΠΟΔΟΧΕΑ ΤΗΣ ΑΚΕΤΥΛΟΧΟΛΙΝΗΣ ΜΕ ΤΗΝ ΒΟΗΘΕΙΑ ΜΟΝΟΚΛΩΝΙΚΩΝ ΑΝΤΙΣΩΜΑΤΩΝ
MYASTHENIA GRAVIS (MG) IS A NEUROMUSCULAR DISORDER MANIFESTED BY WEAKNESS AND FATIGABILITY OF VOLUNTARY MUSCLES DUE MAINLY TO AUTOANTIBODY-MEDIATED LOSS OF ACETYLCHOLINE RECEPTOR (ACHR). ACHR IS A MEMBRANE GLYCOPROTEIN (M.W.-290,000) COMPOSED OF FIVE SUBUNITS IN THE MOLECULAR RATIO OF A2BΓΔ. …
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Molecular analysis of decay accelerating factor as a potential susceptibility factor to developing treatment resistant extraocular muscle involvement in Myasthenia Gravis
Myasthenia gravis (MG) is an autoimmune disorder in which auto-antibodies directed at the acetylcholine receptors (AChR) of the neuromuscular junction (NMJ) block, alter or destroy their targets. The anti-AChR antibodies cause activation of the classical complement pathway leading to inflammatory …
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Health Information Needs of Patients Living with Myasthenia Gravis: A Narrative Inquiry
Myasthenia gravis (MG) is a rare autoimmune disease that affects the neuromuscular junction of voluntary muscles, resulting in muscular dystrophy. The disease is termed the snowflake disease due to the variability of symptoms, disease progression, and effective treatments for each person. As the …
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Force-extension of the Amylose Polysaccharide
Myasthenia gravis (MG) is an autoimmune disorder in which auto-antibodies directed at the acetylcholine receptors (AChR) of the neuromuscular junction (NMJ) block, alter or destroy their targets. The anti-AChR antibodies cause activation of the classical complement pathway leading to inflammatory …
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Cellular requirements for antibody production in a novel LPS-enhanced model of autoimmune myasthenia gravis
… responses to acetylcholine receptor (AChR) in myasthenia gravis (MG) was evaluated in wild type (WT), CD4-/-, and CD8-/- C57BL/6 mice. Historically, MG\r\nhas been induced in mice by immunization with AChR emulsified in complete Freund’s\r\nadjuvant (CFA). WT mice immunized with AChR in LPS …
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Die Rolle der DNA-Methylierung in der Kontrolle des MHC-II-spezifischen Typ-IV-Promotors in Thymomen
… welche häufig mit einer paraneoplastischen Myasthenia gravis (MG) assoziiert sind. Die paraneoplastische MG zeigt eine starke positive Korrelation mit der Fähigkeit eines Thymoms, reife CD4+ T-Zellen zu produzieren und in das periphere Blut zu exportieren. Thymome weisen aus bislang …
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The Level of Antiacetylcholine Receptor Antibodies in the Patients with Myasthenia Gravis
… the neuromuscular transmission. These make the myasthenia gravis (MG) which may cause ptosis, diplopia, dysarthria, dysphagia, generalized weakness, or even respiratory failure. In the previous studies level of antiacetylcholine receptor antibody did not correlate to the severity of patients …
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Exploring the experiences of South African youth living with myasthenia gravis
… experiences of South African youth living with Myasthenia Gravis (MG). Myasthenia gravis is a rare autoimmune disease marked by skeletal muscle weakness caused by the breakdown of communication between nerves and muscles at the neuromuscular junction. The aim was to understand how MG affects …
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A modular and adjustable ptosis crutch as a non-surgical solution to elevating the upper eyelid of myasthenia gravis patients
Myasthenia Gravis (MG) is a treatable autoimmune disorder that affects the neuromuscular junction. MG is characterised by fatigable muscle weakness of voluntary skeletal muscles with the most commonly affected muscles being the eye and facial muscles. Patients of African genetic ancestry, …
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Myasthenia Gravis mimics: An audit of cases identified at Groote Schuur Hospital over 20 years
Background: Myasthenia gravis (MG) is characterised by fatigable muscle weakness. The diagnosis is made clinically and supported by ancillary tests such as electrophysiological studies, autoantibodies and pharmacological responses. Autoimmune MG will respond to immune therapy. Although there are …
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Ανασυνδυασμένα τμήματα του ανθρώπινου νικοτινικού υποδοχέα για την κατανόηση των παθογενετικών μηχανισμών της βαριάς μυασθένειας
… μεταξύ των οποίων και η βαρειά μυασθένεια (Myasthenia Gravis-MG). Η μυασθένεια χαρακτηρίζεται από χρόνια μυϊκή αδυναμία, προκαλούμενη από τη δράση αντισωμάτων υψηλής συγγένειας έναντι του μυϊκού τύπου AChR. Με απώτερο σκοπό τη διερεύνηση της παθογονικότητας των αυτοαντισωμάτων έναντι …
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Treatment-resistant ophthalmoplegia in myasthenia gravis: Clinical, molecular and functional studies of patient-derived orbital tissues
Introduction: Myasthenia gravis (MG) is an immune-mediated disorder affecting the neuromuscular junction. Weakness of the extraocular muscles (EOMs) occurs frequently in MG and typically responds to immune therapies similarly to the non-ocular muscles. Susceptible individuals with the …
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Investigating the functionality of candidate susceptibility genes in ophthalmoplegic myasthenia gravis using patient-derived material
Ophthalmoplegic myasthenia gravis (OP-MG) is a subphenotype of an autoimmune disease, myasthenia gravis (MG). This subphenotype described by our group is characterised by extraocular muscle (EOM) weakness which does not respond to standard immunosuppressive therapy whilst the non-ocular muscles do …
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Identifying the molecular basis for treatment resistance in a subset of myasthenia gravis patients of African ancestory
Myasthenia gravis (MG) is an autoimmune disease in which pathogenic antibodies block, target or destroy the acetylcholine receptors of the muscle endplate resulting in failure of neuromuscular transmission and fatigable weakness. We have previously shown that a subpopulation of South African MG …
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Ανασυνδυασμένη πρωτεϊνική κινάση MuSK και χρήση της για την ανάπτυξη αντιγονοειδικής θεραπείας της MuSK-εξαρτώμενης βαριάς μυασθένειας
Η μυασθένεια gravis (Myasthenia gravis, MG) είναι μία αυτοάνοση νόσος η οποία επηρεάζει την ομαλή λειτουργία της νευρομυϊκής σύναψης. Το μεγαλύτερο ποσοστό των ασθενών (80-85%) εμφανίζουν αντισώματα έναντι του μυϊκού υποδοχέα της ακετυλοχολίνης (AChR), ενώ 5-7% των ασθενών εμφανίζουν αντισώματα …
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Treatment-resistant ophthalmoplegia in Myasthenia gravis: extraocular muscle pathology, the role of TGFβ1 and the derivation of induced pluripotency towards 'disease-in-a-dish' modeling
Myasthenia gravis (MG) is an autoimmune disease in which pathogenic antibodies target specific neuromuscular junction proteins, most frequently acetylcholine receptors (AChR). Among those without detectable AChR-antibodies, a subgroup of patients has antibodies directed against muscle-specific …
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Abnormes Mikromilieu und gestörte Thymopoese in Thymomen als Grundlage der Autoimmunisierung im peripheren Immunsystem
… vermindert sind. Zusätzlich weist das Thymomgewebe im Vergleich zum Thymus weniger B-Zellen und Effektor-T-Zellen auf. Bisher ist unbekannt, welche Faktoren die veränderte intratumoröse Zusammensetzung der Zellpopulationen bedingen. Ziel der vorliegenden Arbeit war es daher, …