Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 75 for “"MyD88"”.
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Investigating the role of MyD88 signalling pathway in immune mediated diseases
… differentiation primary response protein (MyD88) plays a central role in innate immune signalling by acting as an adaptor protein downstream of most of the Toll-like receptor (TLR) family and all the IL-1 receptor family members. Activation of MyD88 dependent signalling is critical for the …
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MyD88-Mediated Signaling in Protective Immunity against an Attenuated West Nile Virus Infection
… (TLR) 7/myeloid differentiation factor 88 (MyD88)-mediated signaling pathways protect host against wild-type WNV infection. Both MyD88-/- and TLR7-/- mice had reduced effector T cell functions compared to wild-type mice following NS4B-P38G mutant infection. TLR7-/- mice displayed normal …
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An investigation of the activation of protein kinase complexes in the MyD88 signalling network
The TAK1 and canonical IKK complexes are the two master protein kinases of the innate immune system that control the production of inflammatory mediators, but the mechanisms by which they are activated in this system are still unclear. In this thesis, I present the research I have carried out to …
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Roles of MAVs and MYD88 in Innate and Adaptive Immune Responses to Respiratory Syncytial Virus
… they signal through the adaptors TRIF (TLR3, 4), MyD88 (TLR4, 7/8, 9), and MAVS (RIG-I). The innate response serves to limit viral spread and to activate adaptive immune responses which eventually clear the infection. We dissected the contribution of TLR- and RLR- mediated recognition in the host …
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Protective Role of Mesenchymal MyD88 Signaling Under Homeostasis and Initiation of Inflammation in the Colon
… requires myeloid differentiation factor 88 (MyD88). Overall, MyD88-dependent interactions between the microbiota and the host is reported to contribute to epithelial barrier restoration via repositioning of mesenchymal stromal cells producing COX-2/PGE2 during injury. However, whether MyD88 …
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Exploring the bidirectional interface between stress and innate immunity: a focus on glucocorticoid and TLR4-MyD88 signalling
… by focusing on glucocorticoid and TLR4- MyD88 signalling. The research was undertaken in a series of 3 studies. Study 1 investigated the impact of baseline TLR4-MyD88 signalling on the neuroendocrine and behavioural responses to acute stress. Through examining stress responses in mice …
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Innate Immunity to Listeria monocytogenes Infection: Regulation of Dendritic Cell and Neutrophil Responses by MyD88 and the Type I IFN Receptor
<italic>Listeria monocytogenes (Lm)</italic> is an intracellular bacterial pathogen that is of consequence to pregnant women and immunocompromised individuals. Exploiting a niche, <italic>Lm</italic> gains access to the host cell cytosol via the pore forming toxin listeriolysin O (LLO) and infects …
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Structural and Biochemical Studies of the Innate Immune Pathway
… series of molecular recognition experiments with MyD88. In vitro transcription and translation pull-down experiments performed with IRAK-4 DD and MyD88 suggest that the ID of MyD88 might mediate this interaction.
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Isolation of innate immune response genes, expression analysis, polymorphism identification and development of genetic markers for linkage analysis in common carp (Cyprinus carpio)
… TLR4a, TLR4b, TLR7a, TLR7b, TLR9, TLR21, TLR22, MyD88a, MyD88b, TRAF6a, TRAF6b, type I IFN, IL-1β, IL10a and IL10b. Putative SNPs were genotyped in a SNP discovery panel consisting of different common carp strains and koi to evaluate their allele frequencies and in a full-sib family to validate …
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Chlamydia pneumoniae, Toll-like Receptors and Pathogenesis of Atherosclerotic Heart Disease
… formation. In myeloid differentiation factor 88 (MyD88)-deficient macrophages, TLR4 and TLR3 agonists each induce foam cell formation in the absence of exogenous LDL, suggesting that MyD88-mediated signaling interferes with MyD88-independent foam cell formation. A synthetic liver X receptor (LXR) …
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The role of BCAP in regulating the TLR signalling pathway
… TIR-domain-containing adaptors MAL and MYD88. BCAP (B-cell adapter for PI3K) was identified as a negative regulator in the TLR4 MYD88-dependent signalling pathway. This study utilises biochemical, biophysical and structural biological techniques and focuses on two hypotheses to elucidate …
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The role of TLR3- and MyD88-dependent signaling in the development of anti-West Nile virus adaptive immune responses induced by a vaccine candidate, RepliVAX WN.
… We examined and compared the role of TLR3- and MyD88-dependent signaling in the development of anti-WNV-specific T cell responses by examining the kinetics of WNV-specific IFN-γ secreting CD4+ and CD8+ T cell responses, the functional pattern of primary and secondary effector WNV-specific IFN-γ …
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A transcriptomic approach for studying the activation of dendritic cells in response to mycobacterial infections
… IRFs can function independent of the adaptor MyD88 (Myeloid Differentiation Factor 88) in M. tuberculosis infected BMDCs, which is surprising considering the important role played by MyD88 in the Toll mediated signalling pathway. Exvivo experiments also show that MyD88 may not be absolutely …
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Toll-like receptor mediated responses to adsorbed damage-associated molecular patterns on biomaterial surfaces
… confirmed the similar contribution of TLR2- and MyD88-dependent signalling in pro-inflammatory, anti-inflammatory, and angiogenic cytokine gene expression and production in response to model cannula surfaces with adsorbed DAMPs and plasma. Trends in the results from short term cannula implants in …
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MAPPIT analysis of the early events in Toll-Like receptor signalling
… Daarbij zijn vier adaptor molecules betrokken: MyD88, Mal, Trif and Tram. Verschillende TLRs gebruiken verschillende combinaties van adaptoren, wat gedeeltelijk de ligand specifieke respons kan verklaren. Door gebruik te maken van MAPPIT (Mammalian Protein-Protein Interaction Trap), een …
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Understanding the Myddosome Complex: An Exploration of How Homotypic Death Domain Interfaces Contribute to Overall Structure.
… Lin et al [1], by combining the Death Domains of MyD88, IRAK4 and IRAK2. The complex was shown to form a left-handed helical tower as it assembles in a staggered hexagonal pattern, due to the three characteristic types of homotypic Death Domain (DD:DD) interactions seen in complexes of the Death …
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Expression and Function of Toll-Like Receptor 2 and 4 in Human Melanocytes
… CD14 and myeloid differentiation factor-88 (MyD88) was shown by RT-PCR. Protein expression and localization of TLR2, TLR4 and CD14 were detected by western blot, flow cytometry and immunocytochemistry. Lipopolysaccharide (LPS) was used as microbial stimulator on melanocytes. The expression of …
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