Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"Mutational process"”.
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Genomic aberrations as determinants of immune infiltrates in high grade serous ovarian carcinoma
… in high grade serous ovarian cancer (HGSOC), mutational processes by which tumours gain immunogenicity or develop immune evasion are yet to be identified. Mutational processes that play a key role in HGSOC tumourigenesis leave imprints of copy-number aberrations (CNA) in the patient’s genome. …
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Germline and somatic mutational processes across the Tree of Life
… consensus sequencing (CCS) employs a highly processive, engineered DNA polymerase to repeatedly sequence both the forward and reverse strands of a circular DNA template. By leveraging the redundancy of multiple passes and the complementarity of the strands, a consensus algorithm generates a …
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Somatic Mutation in Cancer and Healthy Human Tissue
Somatic mutation is a natural process in healthy human tissues but has significant implications in a range of disorders and diseases with cancer being the most prominent example. In the last decade, genomics research generated big data resources that contributed tremendously to our understanding …
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An Investigation of Mutational Signatures in the Evolution of Oesophageal adenocarcinoma
An Investigation of Mutational Signatures in the Evolution of Oesophageal adenocarcinoma Sujath Abbas Oesophageal adenocarcinoma (OAC) remains a public health challenge with dismal survival rates and increasing incidence. This PhD study aimed to investigate how mutational processes act across …
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Tumour evolution in ovarian cancer using high-throughput genomics technologies
… in the relapsed disease. I then asked which mutational process drives evolution. Using next-generation sequencing (NGS), I compared the structural variants between and within cases in the model system and in 6 cases of the OV03 cohort. From the genomic signatures in the cell lines, I …
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The somatic evolution of the canine transmissible venereal tumour
… work aims to illuminate the history, diversity, mutational exposures and evolution of the CTVT lineage, and to characterise the major evolutionary forces which operate on cancer over long time frames. The dissertation is structured in seven chapters, each composed of four sections. The first …
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Mutational processes in normal human tissues
… technological limitations, we are still in the process of understanding patterns of somatic mutation in normal cells. This accumulation of somatic mutations is shaped by numerous mutational processes, each generating a distinctive profile of mutations, called a ‘mutational signature’. From …
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Compositional models for mutational signature analysis
Background: Cancer is a process whereby the accumulation of mutations leads to a clonal expansion of cells, forming a tumour mass with the capacity of expanding to surrounding tissues. Understanding how these mutations come to be in the first place is important from an epidemiological and …