Global ETD Search
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Showing 1 to 3 of 3 for “"Mutational Paths"”.
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Characterization of beneficial mutations in unsaturated fatty acid biosynthesis that are recurrent dead-ends in a long-term evolution experiment with Escherichia coli
… glucose environment and explored different mutational paths to higher fitness. Genome sequencing identifies genes that accrue mutations early in evolution across the twelve evolving populations. These parallel mutations typically provide a significant fitness benefit and often fix in the …
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Predicting Mutational Pathways of Influenza A H1N1 Virus using Q-learning
… not capture the multidimensional complexity of mutational pathways. We suggest representing antigenic drifts within influenza A/H1N1 hemagglutinin (HA) protein as a graph, $G = (V, E)$, where $V$ is the set of vertices representing each possible sequence and $E$ is the set of edges representing …
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Decoding structure-function relationships of glycans
… structural determinants required, and potential mutational paths, for H5N1 to quantitatively switch it's binding specificity to human glycans receptors, ii) identify the mutations that enable the 2013 outbreak H7N9 HA to improve binding to human glycan receptors in the upper respiratory tract, …