Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"Mutant TP53"”.
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Cooperative Genomic Events Driving Mutant TP53-Driven DCIS Progression
… of human DCIS and breast cancer suggest that <em>TP53</em> mutations occur early in DCIS, suggesting a critical role for mutant <em>TP53</em> in driving disease progression. Using a somatic mouse model of <em>p53<sup>R245W</sup></em> induced breast cancer (equivalent to the …
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Novel RNA-based biomarkers for ovarian cancer – uncovering how LINC01132 is regulated by the tumour suppressor protein, p53
… expressed in ovarian cancer cells with mutant TP53, compared to those with the wildtype gene. Here, we show that three p53 mutants (R175H, I195T and R248Q) commonly found in ovarian cancer patients, were unable to activate firefly luciferase expression from a synthetic p53-responsive …
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Epitranscriptional Control of the Caspase-2—MDM2—p53 Axis: The Role of the m6A Writer in p53 Signaling.
… Pharmacological inhibition and catalytic-dead mutants confirmed that m6A deposition, rather than the scaffolding role of METTL3, underlies this regulatory effect. Epitranscriptomic profiling via m6A-Seq2 revealed that both p53 and MDM2 transcripts harbor prominent m6A peaks within their 3′UTRs. …
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Investigating Checkpoint Kinases 1/2 As Novel Therapeutic Targets In Head and Neck Squamous Cell Carcinoma
… high rate of treatment failures in HNSCC. TP53 is the most frequently mutated gene in HNSCC, and the effect of p53 loss or mutation on cisplatin responses in HNSCC is poorly understood. In the current study, we hypothesized that HNSCC cells respond to cisplatin in a p53 dependent manner and …
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A novel mechanism for the anti-cancer activity of aspirin and its analogues
… in patients with CRC tumours that harbour mutant TP53 gene and normally resistant to oxaliplatin. It is therefore proposed that the perturbation of EGF internalization is a novel mechanism of action for aspirin and its analogues in cancer therapy. These positive findings shed light on the …