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Showing 1 to 20 of 39 for “"Mutagens"”.
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A Search for Mutagens Which Induce A: T Transversions in Bacteriophage T4
Made available in DSpace on 2014-12-11T18:16:56Z (GMT). No. of bitstreams: 1 7500415.pdf: 5869110 bytes, checksum: c16fa1e441603fd38a7db393127660dd (MD5) Previous issue date: 1974
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Influence of Chlorination and the Distribution System on Mutagens in a Potable Water Supply
Mutagens were recovered from a Central Illinois potable water supply by adsorption on polyurethane foam plugs. Assay of these concentrates with the Ames Salmonella/microsome reversion assay showed both promutagenic and direct-acting responses in TA98. Examination of the water at the groundwater …
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Detection and identification of human cell mutagens in sediments and surface waters of the Aberjona watershed
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Civil and Environmental Engineering, 1993.
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Application of attenuated total reflection Fourier transform infrared (ATR-FTIR) spectroscopy to measure sub-lethal effects of potential mutagens
Techniques employed in vibrational spectroscopy monitor the vibrational modes of functional groups within biomolecules and enable a correlation between chemical information and histological structures. Interrogation of biological samples using infrared (IR) techniques generates spectrum with …
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In vitro chemically-induced DNA damage in cancer patients and healthy individuals. The effect of genotoxic compounds in cells from polyposis coli, colon cancer patients and healthy individuals.
… the sister chromatid exchange assay. The food mutagens, PhIP and IQ, as well as titanium dioxide nanoparticles (TiO2 NPs) induced a dose dependent increase in the DNA damage and chromosomal abnormalities in all tested groups regardless of confounding factors. Prior to experiments …
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The plant-activation of m-phenylenediamine and its mutagenic, biochemical and molecular characterization
… or animal systems. Many aromatic amines are promutagens and plants can activate these agents into stable mutagens. The biochemical and molecular mechanisms involved in bioactivation of promutagens into mutagens have been partially revealed in mammalian systems to understand cancer induction …
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Point mutations in normal lungs of smokers and non-smokers
It is a widely-held hypothesis that environmental mutagens play an essential role in human somatic and germinal cell mutagenesis. In particular, the finding of small amounts of chemical mutagens in cigarette smoke has led to the general hypothesis that mutagens in cigarette smoke induce …
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Regulation of the ribonucleotide reductase small subunit gene in Dictyostelium discoideum
… transcript increases when cells are treated with mutagens and with hydroxyurea, an inhibitor of ribonucleotide reductase. The response is rapid, transient and independent of protein synthesis. A DNA fragment consisting of the 450 bp upstream of the start codon of rnrB has been shown to be …
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Evaluating Determinants of Mitochondrial Mutagenesis and their Intersections with Cell Fate
… in either the form of established nuclear mutagens benzo[a]pyrene or N-ethyl-nitrosourea, for their effects on mtDNA frequency with newly developed droplet digital PCR assays. Here I found that these classic nuclear mutagens damage mtDNA, but are not capable of significant mtDNA mutation …
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An investigation into the potential mutagenicity of South African traditional medicinal plants
… added to the in vitro cell system to detect pro-mutagens that require metabolic activation in order to exert mutagenicity or clastogenicity - directly acting mutagens do not require metabolic activation. A significant mutagenic potential (p 0.01) was evident with the Salmonella reverse mutation …
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Harnessing New Genomics Technologies to Assess Environmental Risk Factors That May Cause Heritable Genetic Disease
… sperm and offspring. To test the hypothesis that mutagens induce germline mutations that are inherited in the offspring, MutaMouse males were exposed to 100 mg/kg/day of benzo[a]pyrene (BaP), a known mutagen and common environmental pollutant, and mated to produce offspring. First, sperm from …
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Study of mutation, mutants, and repair in the blue-green alga Agmenellum quadruplicatum
… areas. First, it is desirable to know which mutagens are capable of causing stable mutations in blue-greens. Several mutagens have been reported to cause mutation in blue-green algae; but in only a few of these cases were stable mutant clones isolated from the wild type (3, 24). Once it is …
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The Mutagenicity of Nutmeg, Mace and Black Pepper and some Oil Constituents
… Mace and black pepper were shown to be weak mutagens to TA1537 with and without metabolic activation. Nutmeg exhibited no mutagenic activity in any strain. It is hypothesized that the mutagenicity of the spices was not due to safrole alone but that other unidentified oil constituents may have …
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Lethal and Semilethal Mutation Frequency of the First and Second Chromosomes in Two Natural Populations of "Drosophila melanogaster"
… of trichloroethylene (TCE) and other suspected mutagens and carcinogens, i.e., vinyl chloride, chloroform, etc., have reportedly been found in subsurface soil and waters near downtown Des Moines, Iowa. Lethal gene frequency of the first (X) and second chromosomes of the toxic population sample …
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Effects of arsenic and UVB radiation on induction of cyclin D1 in human keratinocytes.
… of cyclin D1, culturing cells with both co-mutagens does not lead to a potentiated effect. Evidence from other systems indicates that both arsenic and UVB affect promoter activity in various ways, including methylation. We undertook to examine the effects of arsenite and UVB on activation of …
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Sperm sequencing reveals extensive positive selection in the human germline
… to damage from intrinsic causes or exposure to mutagens. Mutations that occur in reproductive cell lineages are known as germline mutations and have the potential to be transmitted to offspring. Germline mutations serve as the origin of all heritable genetic variation, making them crucial in the …
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The cell-intrinsic innate immune response to DNA damage in human cells
… immune response in tissues exposed to chemical mutagens – this has implications in the clearance of cancer cells after chemotherapy-induced DNA damage, with evidence that the immune response mounted by patients may determine chemotherapy responsiveness. To investigate the immune events following …
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Spectroscopic analysis and synthesis of nucleoside analogs for lethal mutagenesis
… could provide a variety of untested lethal mutagens for further study.
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Molecular Dosimetry Studies of Forward Mutation Induced at the YG2 Locus in Maize by Ethyl Methanesulfonate
… of health risks posed to humans by chemical mutagens appears to require consideration of other factors in addition to DNA dose or adduct formation, including differences in repair capabilities and in the size of the genetic targets in humans relative to the model genetic systems under study.
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