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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 42 for “"Mutagenicity"”.
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BIOTRANSFORMATION AND MUTAGENICITY OF BENZIDINE
… effect such biotransformation would have on the mutagenicity of the compound. Bacteria were collected from sites of toxic waste dumping and from estuarine, lake, and ocean locations. Sediment and water samples as well as bacterial isolates were incubated in media containing 100 (mu)g ml('-1 …
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The carcinogenicity, mutagenicity, and toxicity of arsenic and cadmium
… metals. As a result, there is an increase in mutagenicity and toxicity in the organisms. This thesis reviews the current literature relevant to the biochemistry and biology of arsenic and cadmium.
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The toxicity and mutagenicity of the aflatoxin B₁ formamidopyrimidine DNA adduct
Aflatoxin B1 (AFB1) is a fungal metabolite that contaminates the food supply in certain areas of the world. It is produced by Aspergillusflavus and related fungi that grow on improperly stored foods such as corn, rice, and peanuts. Epidemiological studies have shown a correlation between exposure …
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Mutagenicity of root canal sealer RSA Roekoseal Automix in the Ames test
The mutagenic activities of the root canal sealers, RSA Roekoseal Automix and AHPIus, were tested in the bacterial gene mutation assay (Ames test). Both materials were tested immediately after mixing and after setting 24 h. The Salmonella typhimurium tester strains TA98 and TA 100 were used to …
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The Mutagenicity of Nutmeg, Mace and Black Pepper and some Oil Constituents
… safrole, eugenol and myristicin, were tested for mutagenicity using the Aines test.</p> <p>Safrole, an oil constituent, is a weak hepatic carcinogen in the rat and mouse. Safrole metabolites are more mutagenic than the parent compound. Myristicin and eugenol are structurally related to safrole and …
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Inhibitory Effects of Isothiocyanates on the Mutagenicity and Metabolism of Environmental Carcinogens
… isothiocyanate (PEITC) on the metabolism and mutagenicity of 4-(methylnitrosamino)-l-(3-pyridyl)-lbutanone (NNK) and benzo[a]pyrene (BaP) by F344 rat and male Syrian golden hamster liver microsomes were investigated. In addition, the alkyl chain-length effects of BITC and PEITC, together with …
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An investigation into the potential mutagenicity of South African traditional medicinal plants
The potential mutagenicity and clastogenicity (ability to cause chromosomal damage) of five South African traditional medicinal plants: Acokanthera oppositifolia (Lam.); Pelargonium sp. cf. inquinans ( L.) L Herit; Pteridium aquilinum subsp aquilinum; Rumex lanceolatus Thunb. and Zantedeschia …
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Studies of gastric aspirate nitrite, pH, bacterial flora and mutagenicity in man
… specimens were isolated and identified, and the mutagenicity ratios of the aspirates were determined. The median nitrite concentration of the gastric aspirates from the carcinoma patients was significantly higher than that obtained for the non-carcinoma patients. A positive correlation was found …
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Influence of DNA sequence context on O⁶-methylguanine mutagenicity in Escherichia coli
Thesis (Ph.D.)--Massachusetts Institute of Technology, Dept. of Chemistry, 1999.
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Industrial history, mutagenicity, and hydrologic transport of pollutants in the Aberjona watershed
Thesis (Civ. E.)--Massachusetts Institute of Technology, Dept. of Civil Engineering, 1991.
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Modulatory Effects of Citrus Flavonoids Towards the Metabolism and Mutagenicity of Environmental Carcinogens
<p>The environmental carcinogens classified as heterocyclic amines (HCA’s) and the tobacco-specific nitrosamine NNK generally require internal enzymatic activation. This activation occurs via cytochrome P450 (CYP) enzymes and leads to metabolites that bind to human DNA which may in turn cause …
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Cytotoxicity and Mutagenicity of Disinfection Byproduct Mixtures Formulated Using Free Chlorine and Monochloramine
… base-substitution mutations in hisG46. Mutagenicity was greater with the DBP mixtures formulated with free chlorine and bromide, suggesting that bromine-substituted DBPs were important contributors. Exogenous NDMA had a synergistic effect in the concentrate formulated with monochloramine …
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An investigation of structure activity relationships for aryl nitrenium stability and mutagenicity for amino polyaromatic hydrocarbons
… stability. These values were then compared to mutagenicity data from the Ames Salmonella assay. Physical descriptors of isomer classification (based on ring size and shape) and isomer position of substitution were used in the statistical analysis. A strong correlation between mutagenicity, …
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The versatile E. coli adaptive response protein AlkB mitigates toxicity and mutagenicity of etheno-, ethano-, and methyl-modified bases in vivo
The Escherichia coli AlkB protein is an exceptionally versatile DNA repair enzyme. Its expression is induced upon exposure to alkylating agents as part of the Ada-mediated adaptive response. This member of the ac-ketoglutarate/iron(II)-dependent dioxygenase family was originally discovered to …
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Influence of Chlorination and the Distribution System on Mutagens in a Potable Water Supply
… that the level of both direct and activatable mutagenicity increased within the distribution system. The utility studied uses a groundwater source that contains ammonia and methane. To control taste and odor problems the utility alternates disinfection practice from chloramine to chlorination …
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Studies on the Synthesis and Metabolism of 1-(l-Arginine)-1-Deoxy-D-Fructose and the Possible Mutagenic Effects of Maillard Reaction Mixtures
… compared to a 32 hour maximum in the controls. Mutagenicity testing was conducted on Maillard products using the Ames mutagenicity test. Twenty-one amino acids were individually heated with dextrose and these reaction mixtures were tested with Salmonella typhimurium strains TA 98, TA 100 and TA …
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Next-generation sequencing as a tool for investigating the in vivo biological consequences of DNA lesions and its applications on the ethenoguanine, 8-oxoguanine and 1,3-butadiene-induced lesions
… carcinogenesis. The in vivo genotoxicity and mutagenicity of four 1,3-butadiene-induced adenine adducts were evaluated. Previous in vitro studies have shown that some of these lesions are highly mutagenic. Surprisingly, we found that none of them was significantly mutagenic in any of the …
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CYTOTOXIC EVALUATION OF SOME MANNICH BASES OF CONJUGATED STYRYL KETONES
… over a long period of time, carcinogenicity, mutagenicity and resistance may develop. These problems necessitate the development of new anticancer drugs which could target biomolecules other than nucleic acids and which should have different chemical available medication. To seek to overcome …
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Phytochemical and biological investigation of erigeron annus (L.) Pers for antimicrobial activity and potential DNA gyrase inhibitors
… activity, DNA gyrase inhibitory activity and mutagenicity assessment were evaluated on isolated compounds and extracts.
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