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Showing 1 to 20 of 30 for “"Mutagen"”.
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Strategies for reducing the mutagen content of chlorinated aqueous media
… mandates regulating the quantity of the toxic mutagen, 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone, which can be released into potable waters or from industrial facilities, technologies for monitoring the concentration, reducing the quantity, and inhibiting the formation of this …
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Influence of Chlorination and the Distribution System on Mutagens in a Potable Water Supply
Mutagens were recovered from a Central Illinois potable water supply by adsorption on polyurethane foam plugs. Assay of these concentrates with the Ames Salmonella/microsome reversion assay showed both promutagenic and direct-acting responses in TA98. Examination of the water at the groundwater …
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Metabolism of Two Model Xenobiotics in Cultured Plant Cells
… The plant cell metabolism of the promutagen-procarcinogen 2-aminofluorene was evaluated by a mutagen bioassay. The mutagenic activation of 2-aminofluorene by cultured plant cells was detected by the induction of reverse mutation at the his locus of Salmonella typhumerium. A …
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Study of mutation, mutants, and repair in the blue-green alga Agmenellum quadruplicatum
… areas. First, it is desirable to know which mutagens are capable of causing stable mutations in blue-greens. Several mutagens have been reported to cause mutation in blue-green algae; but in only a few of these cases were stable mutant clones isolated from the wild type (3, 24). Once it is …
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The Mutagenicity of Nutmeg, Mace and Black Pepper and some Oil Constituents
… safrole, eugenol and myristicin, were tested for mutagenicity using the Aines test.</p> <p>Safrole, an oil constituent, is a weak hepatic carcinogen in the rat and mouse. Safrole metabolites are more mutagenic than the parent compound. Myristicin and eugenol are structurally related to safrole and …
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Structure elucidation and studies relating to the synthesis of plasmalopentaene-12
… ether, fecapentaene-12, is a direct acting fecal mutagen that is formed in the lower portion of the gastrointestional tract by anaerobic bacteria. The biological precursor to fecapentaene-12 is a natural product of mammalian origin whose role in the etiology of colon cancer is unknown. Preliminary …
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Dietary Protein Concentration and the Metabolism of 1,2-Dimethylhydrazine by Mice
… the metabolism of 1,2-dimethylhydrazine (DMH) to mutagenic products by male B(,6)C(,3)F(,1) mice. Our data reveal that the host-mediated bacterial mutagen assay is a valid indicator of the host's ability to activate DMH and its principle metabolites to carcinogenic products. At concentrations …
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Stabile Expression von Sulfotransferasen - allein oder in Kombination mit Cytochrom P450 - in Zelllinien für Mutagenitätsuntersuchungen
… Die Kanzerogenität der aAA wird durch die Mutagenität hochreaktiver Stoffwechselprodukte vermittelt, die in zwei sequenziellen katalytischen Reaktionen entstehen. Die erste ist meistens eine N-Hydroxylierung, die oft durch Cytochrom P450 1A2 (CYP1A2) katalysiert wird. Daran schließt sich …
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Studies relating to fecapentaene-12
… ether fecapentaene-12 (FP-12) is a direct-acting mutagen that is formed by bacteria in the lower part of the gastrointestinal tract from a precursor of unknown structure. Two major unsolved questions concerning FP-12 are the structure of its precursor and the nature of its interaction (if any) …
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An Intracellular Polysaccharide that Serves as a Carbon and Energy Source for Sporulation in "Bacillus Cereus" Strain T
… cereus" strain T were treated with the chemical mutagen ethyl methane sulfonate and screened for the ability to accumulate and not degrade the intracellular polysaccharide. A suitable mutant (CH-5) was isolated and compared to the wild-type in terms of growth characteristics, polysaccharide and …
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BIOTRANSFORMATION AND MUTAGENICITY OF BENZIDINE
… effect such biotransformation would have on the mutagenicity of the compound. Bacteria were collected from sites of toxic waste dumping and from estuarine, lake, and ocean locations. Sediment and water samples as well as bacterial isolates were incubated in media containing 100 (mu)g ml('-1 …
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Development of Pd Catalyzed Amidations & Applications to the Synthesis of Heterocycles
… as well as the total synthesis of the mutagen 1-Me-5-PhIP.</p> <p>This reaction was then further explored to utilize more readily available catalytic components and to increase the substrate and amide scope.</p> <p>Chapter 3</p> <p>The C2 amination of imidazo[4,5-b]pyridines was …
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Studies On The Determinants Of HIV Mutagenesis And Strategies For Its Enhancement
… However, the precise determinants of viral mutagenesis in HIV-1 and the degree of their contribution to HIV-1 genetic diversity remain incompletely understood. Furthermore, differences in viral mutagenesis among different HIV types (e.g., HIV-1 and human immunodeficiency virus type 2, HIV-2) …
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The effect of oxidative stress in lymphocytes from patients with inflammatory bowel disease and various cancer states compared with healthy control individuals.
… were treated with the heterocyclic amine (food mutagen), IQ and H2O2 and responses were reduced in the presence of the flavonoids, quercetin and epicatechin and compared with HCI similarity treated. In all cells responses were reduced with flavonoids and again CD had higher responses than the UC …
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The effect of oxidative stress in lymphocytes from patients with inflammatory bowel disease and various cancer states compared with healthy control individuals.
… were treated with the heterocyclic amine (food mutagen), IQ and H2O2 and responses were reduced in the presence of the flavonoids, quercetin and epicatechin and compared with HCI similarity treated. In all cells responses were reduced with flavonoids and again CD had higher responses than the UC …
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Harnessing New Genomics Technologies to Assess Environmental Risk Factors That May Cause Heritable Genetic Disease
… sperm and offspring. To test the hypothesis that mutagens induce germline mutations that are inherited in the offspring, MutaMouse males were exposed to 100 mg/kg/day of benzo[a]pyrene (BaP), a known mutagen and common environmental pollutant, and mated to produce offspring. First, sperm from …
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The plant-activation of m-phenylenediamine and its mutagenic, biochemical and molecular characterization
A promutagen is a chemical agent that is not mutagenic in itself but can be metabolically transformed into a mutagen by plant or animal systems. Many aromatic amines are promutagens and plants can activate these agents into stable mutagens. The biochemical and molecular mechanisms involved in …
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Novel mutations of the A mating-type idiomorph in Neurospora crassa
… all A mating-type mutants isolated using UV mutagenesis were sterile and heterokaryon compatible, the result of frame shift mutations within mt A-1. In an attempt to isolate fertile and heterokaryon compatible A mutants, mutational analysiswas performed on mating-type A strains using …
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