Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"Muscle stem cells"”.
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Epigenetic Regulation of Muscle Stem and Progenitor Cells
… cellular identity. The mechanisms regulating muscle stem and progenitor cell identity have ramifications for understanding all aspects of myogenesis. The epigenetic mechanisms regulating muscle stem cells are therefore important aspects for understanding the regulation of muscle regeneration …
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Ipsc Based Gene Correction and Disease Model of A New Class of Lgmd Due to Poglut1 Mutation
… signaling, the pathways important for skeletal muscle stem cell (satellite cells) quiescence and activation. We hypothesize that reduced POGLUT1 activity and impaired Notch signaling is causative of this limb girdle muscular dystrophy through dysfunction of muscle stem cells and myogenic …
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Six1 Is Important for Myoblast Proliferation Through Direct Regulation of Ccnd1
… oculis homeobox family has been tied to skeletal muscle formation. Work completed thus far has allowed our research team to identify the precise mechanism by which Six1 regulates the expression of MyoD, a key myogenic gene, in muscle stem cells. Furthermore, loss-of-function of this protein, …
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Profiling muscle stem cell adhesion using extracellular matrix peptide arrays
… of life and increases pressure on healthcare systems. Declining skeletal muscle (SkM) mass and function coupled with a reduced tissue healing capacity is one of the main drivers of loss of independence in the elderly. Our previous work revealed that aged SkM contains lower levels of certain …
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Aging Skeletal Muscle Plasticity in Exercise and Injury
Sarcopenia—progressive loss of muscle mass and strength—diminishes quality of life and longevity. In addition to progressive atrophy, older adults exhibit impaired regeneration after muscular injury. Activity of muscle stem cells, termed satellite cells, is dysregulated with aging which impairs …
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The Physiological and Genetic Factors Underpinning the Response to Muscle Damaging Exercise
… variability in the response to exercise-induced muscle damage (EIMD), even when tested in a homogeneous cohort accounting for age, sex, ethnicity and physical activity. The response to EIMD is very complex as several tissues, including skeletal muscle fibres, the extra-cellular matrix (ECM), and …
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Development of novel strategies to improve skeletal muscle repair and adaptation following eccentric exercise
… as well as daily activities, can injure skeletal muscle. The repair of muscle damage is essential for effective remodeling, tissue maintenance, and initiation of beneficial adaptations post-exercise. We have previously demonstrated that transgenic overexpression of the α7BX2 integrin in skeletal …
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Analysis of nerve terminal dysfunction in autoimmune neuropathy
… compared the suitability of two common ex vivo muscle preparations for use in characterisation studies, TSC selective antibodies were compared, and EG1 was identified as most suitable for further investigations on the role of the TSC in mammalian NMJ function and as a possible disease target in …
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Whole-Body Metabolic Flexibility is Discordant with Skeletal Muscle Metabolism
… in response to substrate availability. Skeletal muscle (SkM) is a regulator of metabolic flexibility as it is the primary tissue responsible for post-prandial substrate handling, and metabolic inflexibility can be seen in the SkM of individuals with metabolic disease. As Western style diets are …
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Muscle-derived cytokines: novel regulators of skeletal myogenesis
Mature skeletal muscle has a uniquely robust capacity for regeneration. This ability is due in large part to the resident population of muscle stem cells in the tissue, known as satellite cells. These adult stem cells reside in a quiescent state near the basal lamina of skeletal myofibers, but are …
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Single-cell atlasing of the human tissues across the lifespan
… different organs: the human thymus and skeletal muscle. Firstly, I co-led a large multinational effort to create a spatial atlas of the human thymus from fetal and paediatric stages. As a part of this effort, we expanded the census of cell types in the human thymus and mapped them spatially in …
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Optimizing Ex Vivo Culture of Satellite Cells
Satellite cells are responsible for regeneration of skeletal muscles. They have the ability to form new muscle fibers and to repopulate satellite cell pool. Transplantation of human satellite cells to muscle dystrophy patients is an aim. To achieve this aim, we must understand mechanisms governing …
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Stimulation de la régénération endogène dans le traitement de la dystrophie musculaire
… exist. These diseases are characterized by muscle wasting, limited life expectancy and reduced ambulatory capacities. Mutations in proteins implicated in the attachment of muscle fibers to the extracellular matrix cause the fibers to be more fragile, making them more susceptible to rupture …