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Showing 1 to 20 of 28 for “"Muscle proteins"”.
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Hydration and activity studies of bovine skeletal muscle proteins and wheat gliadins by nuclear magnetic resonance
… of water and ion binding to bovine skeletal muscle proteins in solutions and suspensions were carried out as a function of concentration, pH/pD, and salt. Numerical analysis of the data was performed by nonlinear regression on an Apple-MacIntosh II microcomputer, using a thermodynamic linkage …
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Processed Meats and Protein Functionality
… and/or physical changes were occurring to the muscle proteins due to processing conditions. This research approach relates processed meat manufacturing with the functional aspects of muscle proteins.
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Dynamic proteome profiling of human muscle responses to high-intensity interval training
Skeletal muscle is the most abundant tissue in the body and it plays a central role in whole-body metabolism. Physical inactivity and obesity are associated with poor metabolic health due to insulin resistance of peripheral tissues, in particular skeletal muscle. Conversely, a physically active …
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GENERATION OF FULL-LENGTH WILD-TYPE GATA4 PROTEIN AND CHARACTERIZATION OF ITS BINDING TO UNC-45 DOMAINS
<p>Striated muscle UNC-45 (SM UNC-45) protein acts as a chaperone for cardiac and skeletal muscle myosins; regulating their folding, assembly into thick filaments, interaction with other sarcomeric proteins, and degradation. GATA4 is an important transcription factor that regulates the expression …
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Purification and some properties of an alkaline protease from rat skeletal muscle
Various alkaline proteases derived from skeletal muscle have been described by a number of researchers and have been purified to varying degrees. Such alkaline proteases may play an important role in the metabolism of myofibrillar and other muscle proteins and as such deserve to be fully …
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Proteomic Profiling of Animal Models of Myotonia and Motor Neuron Disease
Skeletal muscle provides an organism with a means of reacting to its environments. It is a complex and versatile tissue that is capable of change under a variety of conditions. For example extensive literature has shown muscle transformation from slow-to-fast by decreased motor nerve activity, …
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The role of individual protein turnover in skeletal muscle adaptation
Skeletal muscle tissue demonstrates a remarkable malleability and can adjust its metabolic and contractile makeup in response to alterations in functional demands. As a result, great diversity exists in muscle physiology, biochemistry and energy metabolism, all of which are underpinned by the …
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Effect of vasodilation on the response of muscle protein synthesis to insulin in aging
The loss of muscle with aging (sarcopenia) is an important contributor to disability and physical dependence in older people. Studies have recently found that aging is associated with a relative resistance of muscle proteins to the anabolic action of insulin, even in subjects who do not have …
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Identification of Phosphorylase Kinase Alpha Subunit Binding Partners in Skeletal Muscle
… ALPHA SUBUNIT BINDING PARTNERS IN SKELETAL MUSCLE Soleil Archila August 2004 67 Pages Directed by: Nancy A. Rice, Sigrid Jacobshagen, and Claire A. Rinehart Department of Biology Western Kentucky University Phosphorylase kinase (PhK) integrates neural, hormonal, and metabolic signals in …
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The effects of testosterone propionate on hindlimb immobilized rats
… to cause pronounced atrophy of skeletal muscle. In animals and humans, disuse of a leg due to immobilization can cause pronounced catabolism of many skeletal muscle proteins. Strength, V02 max, oxidative enzyme activities, protein synthesis, and muscle weight are all diminished due to …
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Nutraceutical and functional food bioactive peptides in beef
… during the hydrolysis or fermentation of food proteins or following digestion may exert beneficial physiological effects in vivo. The aim of this work was to isolate, characterise and evaluate Angiotensin-І-converting enzyme (ACE-І) inhibitory, antimicrobial and antioxidant peptides from the …
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Proteomic approaches for the identification of biomarkers of beef tenderness from Longissimus thoracis muscles and plasma of young Limousin-sired bulls
… vary considerably even for the same breed and muscle type, due to intricate biochemical processes and protein-protein interactions. Recently, proteomic and bioinformatic tools have been applied in meat science to identify biomarkers of beef quality. Nevertheless, there are still gaps in our …
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Slow Inactivation of Sodium Channels: Structural Clues and Disease Associations
Voltage gated sodium channels underlie the rapid upstroke of action potentials in electrically excitable mammalian tissues. A cardinal feature of Na+ channels is their ability to rapidly inactivate to a refractory state during membrane depolarization, in a process known as 'fast inactivation'. …
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Molecular biology of cardiac sarcoplasmic reticulum proteins: studies on the structure and distribution of calsequestrin and phosopholamban
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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The Proteomic Response of Northern Elephant Seal (<i>Mirounga Angustirostris</i>) Pups to Physiological Stress During Development
… to fasting and diving, we collected skeletal muscle and (inner and outer) adipose tissue from early-fasting (< 1 week post-weaning) and late-fasting (8 weeks post-weaning) pups. We analyzed the samples with mass-spectrometry-based proteomics using two-dimensional gel electrophoresis. …
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Myogenic Effectors and Disease
Skeletal muscle is essential for life. Inside muscle fibers, filaments of actin and myosin slide on each other to generate the mechanical forces that drive muscle contraction, movement, and breathing. Mutations in muscle-related genes can cause severe diseases in humans. Here we characterize the …
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Contraction and cation contents of skeletal soleus and EDL muscles in age-matched control and diabetic rats
Skeletal muscle atrophy and neuropathy are two major long term complications of diabetes mellitus (DM). This study investigated the effect of streptozotocin (STZ) - induced type I DM on the characteristics of the animals and on contraction, cation contents, morphology and muscle proteins of …
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Fluorescence labeling and computational analysis of the strut of myosin's 50 kDa cleft.
In order to understand the structural changes in myosin S1, fluorescence polarization and computational dynamics simulations were used. Dynamics simulations on the S1 motor domain indicated that significant flexibility was present throughout the molecular model. The constrained opening versus …
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Discovery of New Regulatory Proteins and Mechanisms in Muscle Biology and Disease
In an effort to discover new regulators of muscle function, we identified a novel muscle-specific protein, Klhl40. Genetic deletion of Klhl40 in mice results in a nemaline myopathy-like phenotype with disruption of sarcomere function causing neonatal lethality. Nemaline myopathy (NM) typically …
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The Role of Stac3 in Neuromuscular Synapse Elimination and Maturation
The general metadata -- e.g., title, author, abstract, subject headings, etc. -- is publicly available, but access to the submitted files is restricted to UT Southwestern campus access and/or authorized UT Southwestern users.
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