Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 6 of 6 for “"Muscle myopathy"”.
-
The impact of physical activity on statin-associated skeletal muscle myopathy
… most common side effect of statins is skeletal muscle myopathy, which appears to be exacerbated by exercise. PURPOSE: The purpose of this study was to examine the effects of statin treatment with novel or accustomed exercise in hypercholesterolemic (ApoE-/-) or wild type (WT) mice on muscle …
-
Proteomic analysis of the function of DMPK, the myotonic dystrophy protein kinase
… the most common form of adult-onset skeletal muscle dystrophy, is caused by expansion of a CTG repeat sequence embedded in the 3'UTR of a gene which encodes a serine threonine kinase, DMPK. The precise mechanism by which CTG repeat expansion causes the complex pathology of DM1 is under active …
-
Exercise and free radical induced damage to human skeletal muscle
… free radical induced damage to human skeletal muscle, with a review of related literature. It has been proposed muscle adapts to eccentric exercise by increasing its resting length. The first study investigated the effects of manipulating knee extensor (KE) length during eccentric actions, on …
-
Discovery of New Regulatory Proteins and Mechanisms in Muscle Biology and Disease
In an effort to discover new regulators of muscle function, we identified a novel muscle-specific protein, Klhl40. Genetic deletion of Klhl40 in mice results in a nemaline myopathy-like phenotype with disruption of sarcomere function causing neonatal lethality. Nemaline myopathy (NM) typically …
-
Statin-associated skeletal muscle damage and its interactions with novel or accustomed exercise
… common side effect is some degree of skeletal muscle myopathy. Unfortunately, this side effect is more likely/severe in statin users who are also exercisers. Purpose: To examine the previously unaddressed interactions of statin treatment with novel vs. accustomed exercise, as well as to examine …
-
Mechanisms of Dysregulated Alternative Splicing in Cardiac and Skeletal Muscle under Diabetic Conditions
Under diabetic conditions, cardiac and skeletal muscle undergoes changes that can lead to cardiomyopathy and myopathy respectively. Diabetes patients suffer from skeletal muscle weakness and atrophy. Diabetic cardiomyopathy can progress into heart failure. Currently, no treatments are available for …